Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain

Sejima, Hitoshi; Ito, Masako; Kishi, Kazuko; Tsuda, Hideo; Shiraishi, Hideyuki

doi:10.1016/s0387-7604(96)00492-5

Cited by 66 publications

(28 citation statements)

References 29 publications

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“…Free radicals are normal by products of cellular aerobic metabolism involved in the development of seizures [47]. However, when the production of free radicals increases or the defense mechanism of the body decreases, they cause cellular dysfunction by attacking the polyunsaturated sites of the biological membranes causing lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice

Taïwé

Moto

Ayissi

et al. 2015

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 99%

Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice

Taïwé

Moto

Ayissi

et al. 2015

Epilepsy & Behavior

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“…[34–36] It has been reported that free radical generation due to increased activity of the glutamate plays a fundamental role in neuronal cell death associated with PTZ kindling in rats. [37–39] Free radicals have been implicated in a number of seizure models including PTZ kindling[4041] and some antioxidants have been shown to be effective in these seizure models. [4243] When the production of free radicals increases or the defense mechanism of the body decreases, lipid peroxidation at polyunsaturated sites on biological membranes occurs leading to cell dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant and related neuropharmacological effects of the whole plant extract of Synedrella nodiflora (L.) Gaertn (Asteraceae)

2012

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Purpose:The plant Synedrella nodiflora (L) Gaertn is traditionally used by some Ghanaian communities to treat epilepsy. To determine if this use has merit, we studied the anticonvulsant and other neuropharmacological effects of a hydro-ethanolic extract of the whole plant using murine models.Materials and Methods:The anticonvulsant effect of the extract (10–1000 mg/kg) was tested on the pentylenetetrazole-, picrotoxin-, and pilocarpine-induced seizure models and PTZ-kindling in mice/rats. The effect of the extract was also tested on motor coordination using the rota-rod.Results:The results obtained revealed that the extract possesses anticonvulsant effects in all the experimental models of seizures tested as it significantly reduced the latencies to myoclonic jerks and seizures as well as seizure duration and the percentage severity. The extract was also found to cause motor incoordination at the higher dose of 1000 mg/kg.Conclusions:In summary, the hydro-ethanolic extract of the whole plant of S. nodiflora possesses anticonvulsant effects, possibly through an interaction with GABAergic transmission and antioxidant mechanisms and muscle relaxant effects. These findings thus provide scientific evidence in support of the traditional use of the plant in the management of epilepsy.

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“…It is reported that free radical generation due to the increased activity of the glutamatergic transmitter plays a fundamental role in neuronal cell death of the PTZ kindling in rats. [35][36][37][38][39][40] There are evidence indicating a linkage between the generation of clonic-tonic seizures and the increased formation of free radicals in the brain. [39] Thus, some antioxidants such as ascorbic acid have been shown to be exert anticonvulsant effect in pilocarpine induced SE through the reduction of lipid peroxidation content and increased catalase enzyme activity.…”

Section: Discussionmentioning

confidence: 99%

Free Radical Scavenging and Anti-lipid Peroxidative Effects of a Hydro-ethanolic Extract of the Whole Plant of Synedrella nodiflora (L.) Gaertn (Asteraceae)

Amoateng

Koffuor

Sarpong

et al. 2011

Free Radicals and Antioxidants

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Background: Synedrella nodiflora (L.) Gaertn. (Asteraceae), a native Ghanaian shrub, has been used for the treatment of epilepsy, hiccup and threatened abortion. The present study aimed at investigating the possible mechanisms of antioxidant effects of the hydro-ethanolic extract of the whole plant. Methods: Total phenolic content was determined using the FolinCiocalteau assay and the antioxidant capacity by the phosphomolybdenum method. The antioxidant activity was evaluated by the 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging assays, reducing power assay and inhibition of linoleic acid peroxidation and lipid peroxidation in pentylenetetrazole (PTZ)-kindled rat brains. Results: The extract (0.1-3.0 mg ml -1 ) was found to contain phenolic compounds which could be responsible for the antioxidant properties since the coefficient of correlation between the Total Phenolic Content (TPC) and the Total Antioxidant Capacity (TAC) was high (r 2 = 0.9908). Both n-propyl gallate (0.001-0.03 mg ml -1 ), a reference antioxidant and the extract (0.1-3 mg ml -1 ) exhibited antioxidant properties by reducing Fe 3+ to Fe 2+ in the reducing power test, scavenged DPPH free radicals and effectively inhibited linoleic acid autoxidation and also inhibited lipid peroxidation in PTZ-kindled rat brains. Conclusions:These findings suggest that hydro-ethanolic extract of Synedrella nodiflora contains antioxidant principles which may contribute to its traditional use in epilepsy management.

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Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain

Cited by 66 publications

References 29 publications

Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice

Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice

Anticonvulsant and related neuropharmacological effects of the whole plant extract of Synedrella nodiflora (L.) Gaertn (Asteraceae)

Free Radical Scavenging and Anti-lipid Peroxidative Effects of a Hydro-ethanolic Extract of the Whole Plant of Synedrella nodiflora (L.) Gaertn (Asteraceae)

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