Regional distribution of collagen and haemosiderin in the lungs of horses with exercise‐induced pulmonary haemorrhage

Derksen, F. J.; Williams, Kurt J.; Pannirselvam, R. R.; Feijter-Rupp, Heather De; Steel, C. M.; Robinson, N. E.

doi:10.2746/042516409x429419

Cited by 24 publications

(29 citation statements)

References 24 publications

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“…Recently, other studies have demonstrated that downstream pulmonary veno‐occlusive remodelling occurs in EIPH‐positive horses . This condition, attributable to chronic hypertensive episodes within the lung, as described above, would increase the chances of EIPH reoccurrence and explain the worsening of EIPH with age.…”

Section: Lower Airway Disorders and Their Effects On Respiratory Funcmentioning

confidence: 86%

“…Recent advances in technology have enabled the development of portable endoscopes that may be used during ridden or driven exercise in the field (Fig ) . The advantages of overground endoscopy include the ability to exercise the horse in its natural environment while being ridden and without the need for referral to a specialist centre with a treadmill.…”

Section: Upper Airway Disorders and Their Effects On Respiratory Funcmentioning

confidence: 99%

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Respiratory diseases and their effects on respiratory function and exercise capacity

Erck-Westergren¹,

Franklin

Bayly

2013

Equine Veterinary Journal

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Given that aerobic metabolism is the predominant energy pathway for most sports, the respiratory system can be a rate-limiting factor in the exercise capacity of fit and healthy horses. Consequently, respiratory diseases, even in mild forms, are potentially deleterious to any athletic performance. The functional impairment associated with a respiratory condition depends on the degree of severity of the disease and the equestrian discipline involved. Respiratory abnormalities generally result in an increase in respiratory impedance and work of breathing and a reduced level of ventilation that can be detected objectively by deterioration in breathing mechanics and arterial blood gas tensions and/or lactataemia. The overall prevalence of airway diseases is comparatively high in equine athletes and may affect the upper airways, lower airways or both. Diseases of the airways have been associated with a wide variety of anatomical and/or inflammatory conditions. In some instances, the diagnosis is challenging because conditions can be subclinical in horses at rest and become clinically relevant only during exercise. In such cases, an exercise test may be warranted in the evaluation of the patient. The design of the exercise test is critical to inducing the clinical signs of the problem and establishing an accurate diagnosis. Additional diagnostic techniques, such as airway sampling, can be valuable in the diagnosis of subclinical lower airway problems that have the capacity to impair performance. As all these techniques become more widely used in practice, they should inevitably enhance veterinarians' diagnostic capabilities and improve their assessment of treatment effectiveness and the long-term management of equine athletes.

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Section: Lower Airway Disorders and Their Effects On Respiratory Funcmentioning

confidence: 86%

Section: Upper Airway Disorders and Their Effects On Respiratory Funcmentioning

confidence: 99%

Respiratory diseases and their effects on respiratory function and exercise capacity

Erck-Westergren¹,

Franklin

Bayly

2013

Equine Veterinary Journal

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“…The diagnosis is made by finding blood upon tracheoscopy104 or by detecting hemosiderin in alveolar macrophages 105. Hemorrhage occurs almost exclusively in the caudo‐dorsal lung areas and is associated with macrophagic bronchiolitis and fibrosis 106. The potential association between IAD and EIPH is controversial.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Inflammatory Airway Disease of Horses—Revised Consensus Statement

Couëtil

Cardwell

Gerber

et al. 2016

Veterinary Internal Medicne

316

588

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“…Multiple occurrences of EIPH result in angiogenesis and fibrosis of the lung that ultimately leads to reduced elasticity of the lung and decreased capacity for oxygen uptake (McKane and Slocombe 2002; Williams et al . 2008; Derksen et al . 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of intravenous aminocaproic acid on exercise‐induced pulmonary haemorrhage (EIPH)

Buchholz¹,

Murdock

Bayly

et al. 2010

Equine Veterinary Journal

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SummaryReasons for performing study: The antifibrinolytic, 6-aminohexanoic acid, also named aminocaproic acid (ACA), has been used empirically as a treatment for exercise-induced pulmonary haemorrhage (EIPH) on the unsubstantiated basis that transient coagulation dysfunction may contribute to its development. Objective: To assess the effect of ACA on bronchoalveolar lavage fluid (BALF) erythrocyte counts in horses performing treadmill exercise at an intensity greater than that needed to reach maximal oxygen consumption. Methods: Eight Thoroughbreds were exercised to fatigue 3 times on a 10% inclined treadmill at a speed for which the calculated oxygen requirement was

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Regional distribution of collagen and haemosiderin in the lungs of horses with exercise‐induced pulmonary haemorrhage

Cited by 24 publications

References 24 publications

Respiratory diseases and their effects on respiratory function and exercise capacity

Respiratory diseases and their effects on respiratory function and exercise capacity

Inflammatory Airway Disease of Horses—Revised Consensus Statement

Effects of intravenous aminocaproic acid on exercise‐induced pulmonary haemorrhage (EIPH)

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