Regional differences in triglyceride breakdown in human adipose tissue: Effects of catecholamines, insulin, and prostaglandin E2

Richelsen, Bjørn; Pedersen, Steen; Møller‐Pedersen, Torben; Bak, J. F.

doi:10.1016/0026-0495(91)90078-b

Cited by 168 publications

(111 citation statements)

References 25 publications

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“…Another possibility is that low leptin levels reflect the catecholamine sensitivity of intraabdominal fat cells. Previously, it has been observed that intraabdominal fat cells are more responsive to the lipolytic effect of catecholamines compared with subcutaneous fat cells (55). There is some evidence that catecholamines might inhibit leptin secretion (16) and, as mentioned above, the rate of leptin secretion might be lower in intraabdominal fat tissue than in subcutaneous fat tissue (28,39).…”

Section: Discussionmentioning

confidence: 94%

Leptin Levels Are Associated with Fat Oxidation and Dietary‐Induced Weight Loss in Obesity

et al. 2001

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Objective: To examine the relationship between fasting plasma leptin and 24-hour energy expenditure (EE), substrate oxidation, and spontaneous physical activity (SPA) in obese subjects before and after a major weight reduction compared with normal weight controls. To test fasting plasma leptin, substrate oxidations, and SPA as predictive markers of success during a standardized weight loss intervention. Research Methods and Procedures: Twenty-one nondiabetic obese (body mass index: 33.9 to 43.8 kg/m 2 ) and 13 lean (body mass index: 20.4 to 24.7 kg/m 2 ) men matched for age and height were included in the study. All obese subjects were reexamined after a mean weight loss of 19.2 kg (95% confidence interval: 15.1-23.4 kg) achieved by 16 weeks of dietary intervention followed by 8 weeks of weight stability. Twenty-four-hour EE and substrate oxidations were measured by whole-body indirect calorimetry. SPA was assessed by microwave radar. Results: In lean subjects, leptin adjusted for fat mass (FM) was correlated to 24-hour EE before (r ϭ Ϫ0.56, p Ͻ 0.05) but not after adjustment for fat free mass. In obese subjects, leptin correlated inversely with 24-hour and resting nonprotein respiratory quotient (r ϭ Ϫ0.47, p Ͻ 0.05 and r ϭ Ϫ0.50, p Ͻ 0.05) both before and after adjustments for energy balance. Baseline plasma leptin concentration, adjusted for differences in FM, was inversely related to the size of weight loss after 8 weeks (r ϭ Ϫ0.41, p ϭ 0.07), 16 weeks (r ϭ Ϫ0.51, p Ͻ 0.05), and 24 weeks (r ϭ Ϫ0.50, p Ͻ 0.05). Discussion: The present study suggests that leptin may have a stimulating effect on fat oxidation in obese subjects. A low leptin level for a given FM was associated with a greater weight loss, suggesting that obese subjects with greater leptin sensitivities are more successful in reducing weight.

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Section: Discussionmentioning

confidence: 94%

Leptin Levels Are Associated with Fat Oxidation and Dietary‐Induced Weight Loss in Obesity

et al. 2001

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“…34 IAF depots are more metabolically active with more rapid lipid turnover 35 and greater lipid uptake 36 than subcutaneous fat depots. Omental adipocytes have been shown to be more lipolytic in response to catecholamines 37,38 compared to subcutaneous adipocytes, possibly due to differences in he number and activity of b and a adrenoceptors in the two adipose tissues. 39 Testosterone is shown to promote lipolysis by enhancing catecholamine-mediated lipid mobilization in rat adipocytes.…”

Section: Discussionmentioning

confidence: 99%

Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men

et al. 2000

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OBJECTIVE: To examine the association between baseline testosterone levels and changes in visceral adiposity in Japanese-American men. DESIGN: Prospective observational study. SUBJECTS: Second-generation Japanese-American males enrolled in a community-based population study. MEASUREMENTS: At baseline, 110 men received a 75 g oral glucose tolerance test (OGTT), and an assessment of body mass index (BMI); visceral adiposity measured as intra-abdominal fat area (IAF) using computed tomography (CT); fasting insulin and C-peptide levels; and total testosterone levels. IAF was re-measured after 7.5 y. Subcutaneous fat areas were also measured by CT in the abdomen, thorax and thigh. The total fat (TF) was calculated as the sum of IAF and total subcutanous fat areas (SCF). RESULTS: After 7.5 y, IAF increased by a mean of 8.0 cm 2 (95% CI: 0.8, 15.3). Baseline total testosterone was signi®cantly correlated with change in IAF (r À0.26, P 0.006), but not to any appreciable degree with change in BMI, TF, or SCF. In a linear regression model with change in IAF as the dependent variable, baseline testosterone was signi®cantly related to this outcome while adjusting for baseline IAF, SCF, BMI, age, diabetes mellitus status (OGTT by the WHO diagnostic criteria) and fasting C-peptide (regression coef®cient for baseline testosterone [nmolal] À107.13, P 0.003). CONCLUSIONS: In this Japanese-American male cohort, lower baseline total testosterone independently predicts an increase in IAF. This would suggest that by predisposing to an increase in visceral adiposity, low levels of testosterone may increase the risk of type 2 diabetes mellitus.

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“…It is possible that the intra-abdominal fat depots, although relatively small in comparison with subcutaneous depots, play an important role in normal buffering. Rates of lipolysis from intra-abdominal adipocytes, when measured in vitro, tend to be high [78,79,80], and these high rates of lipolysis must be matched in the postprandial period by high rates of fat deposition [81]. There is some direct evidence for the latter in vivo [82].…”

Section: Site-specific Properties Of Adipose Tissuementioning

confidence: 99%

Adipose tissue as a buffer for daily lipid flux

2002

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Regional differences in triglyceride breakdown in human adipose tissue: Effects of catecholamines, insulin, and prostaglandin E2

Cited by 168 publications

References 25 publications

Leptin Levels Are Associated with Fat Oxidation and Dietary‐Induced Weight Loss in Obesity

Leptin Levels Are Associated with Fat Oxidation and Dietary‐Induced Weight Loss in Obesity

Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men

Adipose tissue as a buffer for daily lipid flux

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