Regional differences in architecture and mineralization of developing mandibular bone

Mulder, Lars; Groningen, Linde B. van; Potgieser, Yvonne A.; Koolstra, J.H.; Eijden, T.M.G.J. van

doi:10.1002/ar.a.20370

Cited by 17 publications

(15 citation statements)

References 37 publications

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“…This is in agreement with the finding that in both fetal and newborn pigs, the posterior area was significantly less mineralized than anterior and middle areas. 18 Furthermore, the regional difference in the present study correlates with the location of the attachments of the masticatory muscles. The masticatory muscles are mainly attached to the posterior area of the mandibular body and their activity can be considered to contribute to the higher stimuli for bone remodeling in the posterior area of the mandibular body.…”

Section: Discussionsupporting

confidence: 62%

“…This is in agreement with similar findings in human 24,28,29 and porcine mandible. 18 It is probably due to the larger surface area of trabecular bone where remodeling can take place, compared to this area in the compact bone. In contrast to the cortical bone of the mandibular body, the trabecular bone of the condyle had a significantly higher degree of mineralization in the hard diet group than in the soft diet group.…”

Section: Discussionmentioning

confidence: 99%

“…It was averaged in each volume of interest. [16][17][18] It is important to recognize the difference between two mineralization parameters. The first, the degree of mineralization of bone, is the parameter that has been used in the present study.…”

Section: Degree Of Mineralizationmentioning

confidence: 99%

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Effect of Food Consistency on the Degree of Mineralization in the Rat Mandible

et al. 2007

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A switch to a soft diet, associated with reduced forces applied to the mandible during mastication, may result in an alteration of the degree of mineralization in the mandible. This alteration may be regionally different. The aim of this study was to analyze this alteration by examination of the degree of mineralization in the mandible of growing rats fed with a hard or soft diet. Fifteen Wistar male rats were used in this investigation. After weaning, six rats were fed with a hard diet and the remaining nine rats with a soft diet. After 9 weeks, three-dimensional reconstructions of the cortical and trabecular bone of their mandibles were obtained using a microCT system. The degree of mineralization was determined for the trabecular bone in the condyle and for the cortical bone in the anterior and posterior areas of the mandibular body. In both diet groups the degree of mineralization was significantly (p < 0.01) lower in the trabecular than in the cortical bone. In the mandibular body, the anterior area showed a significantly (p < 0.01) higher degree of mineralization than the posterior area in both diet groups. In both areas the soft diet group had a significantly (p < 0.05 or 0.01) higher degree of mineralization than the hard diet group. The trabecular bone in the condyle of the hard diet group showed a significantly (p < 0.01) higher degree of mineralization than in the soft diet group. The present results indicate the importance of proper masticatory muscle function for craniofacial growth and development.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Effect of Food Consistency on the Degree of Mineralization in the Rat Mandible

et al. 2007

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“…A qualitative inspection of the μ-CT results suggests the presence of considerably more voids and fewer osteons in the regenerate bone. More voids and fewer osteons likely indicate a lower degree of maturation of this cortical bone [34]. Some cartilage, fibrous tissue, and woven bone associated with voids, were found in the regenerate samples.…”

Section: Discussionmentioning

confidence: 99%

Architecture and Microstructure of Cortical Bone in Reconstructed Canine Mandibles After Bone Transport Distraction Osteogenesis

et al. 2011

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Purpose Reconstruction of the canine mandible using bone transport distraction osteogenesis has been shown to be a suitable method for correcting segmental bone defects produced by cancer, gunshots, and trauma. Although the mechanical quality of the new regenerate cortical bone seems to be related to the mineralization process, several questions regarding the micro-structural patterns of the new bony tissue remain unanswered. The purpose of this study was to quantify any microstructural differences that may exist between the regenerate and control cortical bone. Methods Five adult American foxhound dogs underwent unilateral bone transport distraction of the mandible to repair 30–35 mm bone defects. Animals were sacrificed 12 weeks after the beginning of the consolidation period. Fourteen cylindrical cortical samples were extracted from the superior, medial, and inferior aspects of the lingual and buccal plates of the reconstructed aspect of the mandible and 21 specimens were collected similarly from the contralateral aspect of the mandible. The specimens were evaluated using histomorphometric and micro-computed tomography techniques to compare their microstructure. Results Except for differences in Haversian canal area, histomorphometric analyses suggested no statistical differences in microstructure between regenerate and control cortical bone. Morphological evaluation suggested a consistent level of anisotropy possibly related to the distraction vector. Conclusions After 12 weeks consolidation, bone created during bone transport distraction osteogenesis is comparable to native bone in microstructure, architecture, and mechanical properties. It is proposed that after enough time, the properties of the regenerate bone will be identical to that of native bone.

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“…Micro-CT is a non-destructive analytical method for investigating bone structure 1,[4][5][6][7][8] . This method, unlike the conventional light microscope method, does not need tedious specimen preparation and specialized skills in microscopy.…”

Section: Discussionmentioning

confidence: 99%