Micro-CT Analysis of Rabbit Cancellous Bone Around Implants

Numata, Yoshihiro; Tanaka, Sakae; Suwa, Taketoshi; LeGeros, Racquel Z.; Okazaki, Yoshimitsu; Kobayashi, Kihei

doi:10.2485/jhtb.16.91

Cited by 9 publications

(4 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, in this study we chose to perform a computed tomographic evaluation before the samples were cut and ground in order to obtain a detailed view of the interface. Micro-CT is a reliable non-invasive analytical instrument to quantify the amount of mineralized bone around artificial implants and characterize the bone structures [ 45 , 46 ]. Together with the histological sections, a comprehensive image of the bone can be surveyed and provide a representative description of the healing event.…”

Section: Discussionmentioning

confidence: 99%

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

et al. 2015

View full text Add to dashboard Cite

Polyether ether ketone (PEEK) has been frequently used in spinal surgery with good clinical results. The material has a low elastic modulus and is radiolucent. However, in oral implantology PEEK has displayed inferior ability to osseointegrate compared to titanium materials. One idea to reinforce PEEK would be to coat it with hydroxyapatite (HA), a ceramic material of good biocompatibility. In the present study we analyzed HA-coated PEEK tibial implants via histology and radiography when following up at 3 and 12 weeks. Of the 48 implants, 24 were HA-coated PEEK screws (test) and another 24 implants served as uncoated PEEK controls. HA-coated PEEK implants were always osseointegrated. The total bone area (BA) was higher for test compared to control implants at 3 (p < 0.05) and 12 weeks (p < 0.05). Mean bone implant contact (BIC) percentage was significantly higher (p = 0.024) for the test compared to control implants at 3 weeks and higher without statistical significance at 12 weeks. The effect of HA-coating was concluded to be significant with respect to early bone formation, and HA-coated PEEK implants may represent a good material to serve as bone anchored clinical devices.

show abstract

Section: Discussionmentioning

confidence: 99%

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Therefore, micro CT is frequently used for the study of trabecular structure and hard tissue ultrastructure, and has been applied to studies in various medical fields 35,36) . In animal experiments involving implants, observation by micro CT may not be reliable because measurement of areas close to the implant is difficult due to the artifacts 37,38) . Therefore, in this experiment, rabbit femurs were used after the implants had been removed.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Mineral Density and Area of Newly Formed Bone Around Ti-15%Zr-4%Nb-4%Ta Alloy and Ti-6%Al-4%V Alloy Implants

Numata

Tanaka

Okazaki

et al. 2008

J. Hard Tissue Biology.

Self Cite

View full text Add to dashboard Cite

Abstract:A newly developed titanium alloy, Ti-15%Zr-4%Nb-4%Ta (Ti15Zr4Nb4Ta), has been shown to have excellent mechanical characteristics, corrosion fatigue strength, anticorrosion, cytocompatibility, and biocompatibility. The purpose of this study was to compare the bone mineral density (BMD) and area of newly formed bone around Ti15Zr4Nb4Ta implants to that around Ti-6%Al-4%V alloy (Ti6Al4V) implants. We inserted 2 types of implants (surface treat of the machine and the blast implant) in New Zealand white rabbit femurs under general anesthesia. The rabbit was done perfusion fixation of 4, 8, 16, 24, and 48 weeks later, and the femurs with the implants were collected and we observed the surrounding bone by an implant drawing test. We measured the BMD and the area of the newly formed bone surrounding the implant inserted part using image analysis software Image-Pro PLUS Ver. 4.0 ® which it developed newly in micro focus computed tomography (micro CT). The results showed the machine and the blast implant together, which the BMD and area around the Ti15Zr4Nb4Ta implants were comparable to or greater than those around the Ti6Al4V implants. These results suggested that the new alloy, Ti15Zr4Nb4Ta, might be useful for orthopedic or dental implants with the added advantage of superior biologic safety and mechanical properties than the current alloy, Ti6Al4V.

show abstract

“…Micro-CT can well distinguish the fine structure inside the bone tissue of beagle dogs and can quantitatively analyze the bone reconstruction around the implant (Numata et al, 2007). To quantitatively analyze the osteogenesis difference between different implants, the three-dimensional bone reconstruction of bone growth Figure 14 is a three-dimensional reconstruction model of the control group and Figure 15 is a three-dimensional reconstruction model of the experimental group.…”

Section: Surface Coating Treatmentmentioning

confidence: 99%

Research on porous titanium implants and its animal experiments

Yao

Chen

Zheng

et al. 2020

RPJ

View full text Add to dashboard Cite

Purpose The purpose of this study is to obtain an effective implant with porous structures on its surface, named porous-surfaced implant, which helps to improve the overall stability of the implant and promote the combination of implant and alveolar bone. Design/methodology/approach Porous-surfaced implants with a porosity of 16%, 21%and 32% were designed and the effect of porosity on the strength of the implant was analyzed by ABAQUS software. Porous-surfaced implants with different porosity were printed by selective laser melting and the surface morphology was observed. Animal experiments of implants with porous structures and coating were carried out in healthy beagle dogs. The experimental group was treated with hydroxyapatite coating and the control group was not treated. Bone volume (BV) and total volume (TV) of the implant surface of the experimental group and control group were calculated by Skyscan CTvol software. Findings With the increase of porosity of porous-surfaced implants, the neck stress of the porous-surfaced implants increased and their strength decreased. In addition, in animal vivo experiments, the ratio value of BV to TV of the porous-surfaced implants was between 55.38% and 79.86%, which was the largest when the porosity of porous-surfaced implants was 16%. The internal and surrounding bone formation content of porous-surfaced implants with hydroxyapatite coating was higher than porous-surfaced implants without coating. Originality/value The results of this study show that the pores on the surface of implants can be filled with the new bone and porous-surfaced implants with 16% porosity provide better space for the growth of new bone. The porous structures with hydroxyapatite coating are beneficial to the growth of new bone around implants. The results of this study are helpful to improve the overall stability of implants and to promote the combination of implant and alveolar bone.

show abstract

Micro-CT Analysis of Rabbit Cancellous Bone Around Implants

Abstract: OriginalAbstract:The aim of this study is to observe the three-dimensional structure of cancellous bone formed around dental implants using micro-CT.Methods: Ti implants (Ti-15%Zr-

Cited by 9 publications

References 11 publications

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

Comparison of Bone Mineral Density and Area of Newly Formed Bone Around Ti-15%Zr-4%Nb-4%Ta Alloy and Ti-6%Al-4%V Alloy Implants

Research on porous titanium implants and its animal experiments

Contact Info

Product

Resources

About