Depopulation is one of the key contemporary demographic challenges for Bosnia and Herzegovina. Adverse demographic trends are causing various problems for Bosnian society and its economy, affecting the national and local labor markets, the public pension system, education, the public health system, etc. Therefore, the purpose of this research is to analyze the spatial patterns of depopulation in Bosnia and Herzegovina in order to identify the areas of the country that are particularly vulnerable to negative demographic trends and to identify the factors that may be contributing to these trends. A geospatial analysis of depopulation was carried out by using global and local indices of spatial autocorrelation. To identify spatial patterns of depopulation in Bosnia and Herzegovina, the study used the data on the total population change, natural population change, the vital index, the ageing index, and the ageing coefficient for the period 2013-2021 at the municipal level. The findings of this study can serve as a basis for future demographic research and the demographic development of Bosnia and Herzegovina.