Regional curare for the reduction of the safety factor in human motor end-plates studied with single fibre electromyography.

Schiller, Hans H.; Stålberg, Erik; Schwartz, Martin S.

doi:10.1136/jnnp.38.8.805

Cited by 16 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This generally is attributed to the increase in the drug response sensitivity of endplates with a low safety factor. 17 This attribution may be valid as the drug affects only the postsynaptic membrane; but, this phenomenon also is well explained by the alternative suggested here. The sensitivity of low-safety factor end-plates to curare need not necessarily increase to explain the linear correlation.…”

Section: Discussionmentioning

confidence: 84%

“…17,22 Furthermore, variations in MCD values (⌬MCD) are linearly correlated with the initial jitter. This generally is attributed to the increase in the drug response sensitivity of endplates with a low safety factor.…”

Section: Discussionmentioning

confidence: 98%

“…Previous reports show a positive correlation between jitter and the safety factor, 17,18 but the relationship between these two parameters has not been well studied. The purpose of this study was to develop a mathematical model for characterizing the jitter phenomenon and its related parameters.…”

mentioning

confidence: 93%

See 2 more Smart Citations

Characterization of the relationship between motor end-plate jitter and the safety factor

Lin

Cheng

1998

Muscle Nerve

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Characterization of the relationship between motor end-plate jitter and the safety factor

Lin

Cheng

1998

Muscle Nerve

View full text Add to dashboard Cite

“…Studies in humans have found that after injection of a given dose of curare those motor endplates with the highest initial jitter showed the greatest increase in MCD values. 24 In Lewis rats, jitters progressively decreased with age, suggesting that neuromuscular transmission is facilitated in aged Lewis rats. Aged female BN rats, however, showed signs of disturbed neuromuscular transmission before immunization.…”

Section: Discussionmentioning

confidence: 98%

Age-related susceptibility to experimental autoimmune myasthenia gravis: Immunological and electrophysiological aspects

et al. 1997

View full text Add to dashboard Cite

“…SFEMG assesses neuromuscular junction (NMJ) failure by recording complete failure of myofiber depolarization (blocking) or reduction in efficiency of NMJ transmission measured by an increase in MCD. 11,13,14 Fiber density (FD), measured as the number of unique muscle-fiber action potentials recorded within the active area of the SFEMG electrode, provides an estimate of the packing density of muscle fibers. Increased FD is observed in neurogenic or myopathic diseases that disrupt motor unit organization through denervation and reinnervation, fiber splitting, or changes in muscle fiber diameter.…”

mentioning

confidence: 99%

Axonal degeneration in the Trembler‐j mouse demonstrated by stimulated single‐fiber electromyography

Meekins¹,

Carter²,

Emery³

et al. 2007

Muscle and Nerve

View full text Add to dashboard Cite

The Trembler-j (Tr-j) mouse is a naturally occurring mutant with a point mutation in the peripheral myelin protein-22 gene causing severe peripheral nerve demyelination. It is a genetically homologous murine model for Charcot-Marie-Tooth disease type 1A (CMT 1A). Our prior pilot studies using stimulated single-fiber needle electromyograpy (SSFEMG) showed increased jitter in 60-day-old Tr-j mice compared to age-matched, wildtype animals. The aim of this study was to better elucidate the etiology of increased jitter in Tr-j mice and test the following hypotheses: (1) the increased jitter in Tr-j mice is due to turnover of endplates secondary to axonal degeneration with reinnervation and not to conduction block secondary to demyelination of motor nerve axons; and (2) aging Tr-j mice demonstrate increased jitter and fiber density compared with younger mutant mice due to progressive motor axon loss. SSFEMG studies performed on 60- and 140-day-old mice indicated that average mean consecutive difference (MCD) and fiber density estimates (FDE) were significantly increased in Tr-j mice at both ages compared to age-matched wildtypes. FDE also increased substantially in older mutant mice. Intraperitoneal neostigmine injections produced significant reductions in average MCD in Tr-j mice, suggesting that impaired neuromuscular transmission is an early pathologic feature in these mice and likely reflects distal axonal degeneration. Our findings corroborate our prior pilot study, although in a much larger number of animals across a wider age span. Our study also indicates that SSFEMG, performed in a serial fashion, is a useful, noninvasive method of detecting progressive axon loss in this murine model of CMT 1A. This technique may be a valuable tool to study the affects of genetic or pharmaceutical interventions in murine models of peripheral neuropathy. Muscle Nerve, 2007.

show abstract

Regional curare for the reduction of the safety factor in human motor end-plates studied with single fibre electromyography.

Cited by 16 publications

References 20 publications

Characterization of the relationship between motor end-plate jitter and the safety factor

Characterization of the relationship between motor end-plate jitter and the safety factor

Age-related susceptibility to experimental autoimmune myasthenia gravis: Immunological and electrophysiological aspects

Axonal degeneration in the Trembler‐j mouse demonstrated by stimulated single‐fiber electromyography

Contact Info

Product

Resources

About