1998
DOI: 10.1002/(sici)1097-4598(199805)21:5<628::aid-mus9>3.0.co;2-a
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Characterization of the relationship between motor end-plate jitter and the safety factor

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Cited by 9 publications
(7 citation statements)
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References 25 publications
(47 reference statements)
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“…4). For further assessment of this dissociation, we performed a computer simulation of a stimulated single fiber EMG, using a technique detailed in our earlier report 8…”
Section: Resultsmentioning
confidence: 99%
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“…4). For further assessment of this dissociation, we performed a computer simulation of a stimulated single fiber EMG, using a technique detailed in our earlier report 8…”
Section: Resultsmentioning
confidence: 99%
“…According to the quantal theory, EPP amplitudes depend on the quantal content (number of quanta released at each firing) and the quantal size or MEPP (postsynaptic potential change for each packet release). In this simulation, EPP was calculated using the following equation5, 8: EPP t = m · MEPP(1 − e t /τ ), where EPP t represents EPP amplitude at time t, t is the time after ACh quantal release, m is the quantal content, and τ represents the membrane decay time constant at the end‐plate. It is postulated that m is a binomially distributed variable, which is determined by the number of quanta immediately available for release ( n ) and the probability of release ( p ).…”
Section: Resultsmentioning
confidence: 99%
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“…It has been shown that variations in jitter are most prominent in end-plates with low safety factors which are activated by slight voluntary contraction. 13 In addition, a clinical study comparing the diagnostic yields of stimulation and voluntary SFEMG clearly demonstrated voluntary SFEMG to be of greater utility in revealing motor end-plate dysfunction. 14 In our study, 3 patients showed pronounced NMT abnormality, and 1 had borderline dysfunction of NMT in SFEMG.…”
Section: Commentsmentioning
confidence: 99%