Abnormal Neuromuscular Transmission in Cluster Headache

Ertaş, Mustafa; Baslo, Mehmet Barış

doi:10.1046/j.1526-4610.2003.03103.x

Cited by 8 publications

(11 citation statements)

References 14 publications

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“…36 Another expressive finding is the demonstration of the existence of similar NMT abnormalities in a different type of primary headache syndrome, in cluster type headache as shown by our SFEMG study. 40 We speculate that this finding may also point out to a shared hereditary liability of the trigemino-vascular system and neuromuscular junction for a subclinical and episodic dysfunction. It seems that TGA is a part of this expanded spectrum, with a particular role of the excitatory afferents.…”

Section: Discussionmentioning

confidence: 72%

Subclinical Impairment of Neuromuscular Transmission in Transient Global Amnesia

Ertaş

Bolay

Kocasoy-Orhan

et al. 2007

Cognitive and Behavioral Neurology

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Section: Discussionmentioning

confidence: 72%

Subclinical Impairment of Neuromuscular Transmission in Transient Global Amnesia

Ertaş

Bolay

Kocasoy-Orhan

et al. 2007

Cognitive and Behavioral Neurology

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“…SFEMG is the most sensitive neurophysiological method of assessing the neuromuscular junction in humans. In our preliminary study, three patients with CH showed prominent NMT abnormality and one further patient had borderline dysfunction of NMT on SFEMG (5). Our SFEMG study compared NMT abnormality in MA and CH patients and found that it was more prominent in CH.…”

Section: Discussionmentioning

confidence: 81%

“…Impairment of neuromuscular transmission (NMT) has been detected by stimulation single-fibre electromyography (SFEMG) in migraine with aura (MA) (1)(2)(3)(4). We have recently reported pronounced abnormalities in NMT by SFEMG in a small group of six patients with episodic cluster headache (ECH), suggesting that CH may share the same abnormality of NMT observed in MA (5).…”

Section: Introductionmentioning

confidence: 99%

Subclinical Neuromuscular Transmission Abnormality Detected by Single-Fibre EMG is More Pronounced in Cluster Headache Than in Migraine With Aura

et al. 2007

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The aim was to investigate neuromuscular transmission (NMT) by single-fibre EMG (SFEMG) in a large series of patients having migraine with aura (MA) or cluster headache (CH). Recent studies using SFEMG have shown subclinical dysfunction of NMT in MA and CH. Forty-three patients having MA, 51 with CH and 38 healthy control subjects underwent nerve conduction studies, EMG and SFEMG during voluntary contraction of the extensor digitorum communis muscle. Twenty different potential pairs were recorded and individual, mean and total abnormal individual jitter values were calculated. The results obtained from MA patients were compared with those from CH patients. In MA patients, 32 of 860 jitters were abnormally high, whereas 73 of 1020 of the jitters showed this abnormality in CH patients. None of the control subjects, five MA patients (11.6%) and 11 CH patients (21.6%) were designated as having subclinical NMT abnormality. Thus, patients having junction dysfunction were significantly more common in the CH group. The subclinical NMT abnormality shown by SFEMG is more common in CH than in MA. These two primary headache syndromes may have some shared functional abnormality of NMT constituents which is more evident in CH.

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“…(57–59, 66) used stimulation SFEMG of EDC, Domitrz et al. (61), Ertas and Baslo (69) and Coban (60) used voluntary EDC contraction SFEMG and Terwindt et al. (62) used stimulation SFEMG of frontalis muscle.…”

Section: Single‐fibre Electromyography a Ambrosini And M Ertasmentioning

confidence: 99%

“…They did not take into account the percentage of abnormal fibres. Ertas and Baslo (69) and Coban (60), who also studied SFEMG during voluntary contraction, considered the test as abnormal if 15% or more MCD values exceeded 55 µs and borderline if 10% of MCD values were above this threshold.…”

Section: Single‐fibre Electromyography a Ambrosini And M Ertasmentioning

confidence: 99%

Evaluation and Proposal for Optimalization of Neurophysiological Tests in Migraine: Part 1—Electrophysiological Tests

et al. 2007

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Neurophysiological testing has become a valuable tool for investigating brain excitability and nociceptive systems in headache disorders. Previous reviews have suggested that most neurophysiological tests have limited value for headache diagnosis, but a vast potential for exploring the pathophysiology of headaches, the central effects of certain pharmacological treatments and phenotype-genotype correlations. Many protocols, however, lack standardization. This meta-analytical review of neurophysiological methods in migraine was initiated by a task force within the EUROHEAD project (EU Strep LSHM-CT-2004-5044837-Workpackage 9). Most of the neurophysiological approaches that have been used in headache patients are reviewed, i.e. evoked potentials, nociception-specific blink reflex, single-fibre electromyography, neuroimaging methods (functional MRI, PET, and voxel-based morphometry) and the nitroglycerin attack-provoking test. For each of them, we summarize the results, analyse the methodological limitations and propose recommendations for improved methodology and standardization of research protocols. The first part is devoted to electrophysiological methods, the second to neuroimaging techniques and the NTG test.

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Abnormal Neuromuscular Transmission in Cluster Headache

Abstract: These results suggest that episodic cluster headache may share the same abnormality of neuromuscular transmission observed in migraine.

Cited by 8 publications

References 14 publications

Subclinical Impairment of Neuromuscular Transmission in Transient Global Amnesia

Subclinical Impairment of Neuromuscular Transmission in Transient Global Amnesia

Subclinical Neuromuscular Transmission Abnormality Detected by Single-Fibre EMG is More Pronounced in Cluster Headache Than in Migraine With Aura

Evaluation and Proposal for Optimalization of Neurophysiological Tests in Migraine: Part 1—Electrophysiological Tests

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