Regional coherence changes in the early stages of Alzheimer’s disease: A combined structural and resting-state functional MRI study

He, Yong; Wang, Liang; Zang, Yu‐Feng; Tian, Lihong; Zhang, Xinqing; Li, Kuncheng; Jiang, Tianzi

doi:10.1016/j.neuroimage.2006.11.042

Cited by 492 publications

(428 citation statements)

References 60 publications

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“…ReHo is supposed to change in many psychiatric or neurological diseases. Abnormal ReHo has been observed in the resting state in ADHD [31,50] , schizophrenia [51] , Alzheimer's disease [52] , Parkinson's disease [36] , and major depressive disorder [53] . Particularly, increased ReHo has been found in the medial temporal lobe in patients with temporal lobe epilepsy [54] and in the thalamus in patients with generalized tonic-clonic seizures [55] .…”

Section: Discussionmentioning

confidence: 99%

Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study

et al. 2013

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Methylphenidate (MPH) is one of the most commonly used stimulants for the treatment of attention deficit hyperactivity disorder (ADHD). Although several studies have evaluated the effects of MPH on human brain activation during specific cognitive tasks using functional magnetic resonance imaging (fMRI), few studies have focused on spontaneous brain activity. In the current study, we investigated the effect of MPH on the intra-regional synchronization of spontaneous brain activity during the resting state in 18 normal adult males. A handedness questionnaire and the Wechsler Adult Intelligence Scale were applied before medication, and a resting-state fMRI scan was obtained 1 h after medication (20 mg MPH or placebo, order counterbalanced between participants). We demonstrated that: (1) there were no significant differences in the performance of behavioral tasks between the MPH and placebo groups; (2) the left middle and superior temporal gyri had stronger MPHrelated regional homogeneity (ReHo); and (3) the left lingual gyrus had weaker MPH-related ReHo. Our findings showed that the ReHo in some brain areas changes with MPH compared to placebo in normal adults, even though there are no behavioral differences. This method can be applied to patients with mental illness who may be treated with MPH, and be used to compare the difference between patients taking MPH and normal participants, to help reveal the mechanism of how MPH works.

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Section: Discussionmentioning

confidence: 99%

Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study

et al. 2013

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“…In addition, the decrease in the PCC/PCu coherence was found to be significantly correlated with disease progression, as measured by MMSE scores. More importantly, these findings remained significant even when controlled for regional PCC/PCu atrophy (He et al 2007c). …”

Section: Properties Of Local Spontaneous Activitymentioning

confidence: 91%

“…Both in AD and amnestic type mild cognitive impairment (aMCI), significantly decreased regional coherence, along with some compensatorily increased regional coherence, was found in the posterior cingulate cortex/ precuneus (PCC/PCu) (He et al 2007c;Bai et al 2008), in which a resting hypometabolism has been commonly detected in previous PET studies of early AD. In addition, the decrease in the PCC/PCu coherence was found to be significantly correlated with disease progression, as measured by MMSE scores.…”

Section: Properties Of Local Spontaneous Activitymentioning

confidence: 99%

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

et al. 2010

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As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in brain spontaneous activity observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. We first review the methods used to study spontaneous activity from the perspectives of (1) the properties of local spontaneous activity, (2) the spatial pattern of spontaneous activity, and (3) the topological properties of brain networks. We also summarize the major findings associated with major neuropsychiatric disorders obtained using these methods. Then we review the pilot studies that have used spontaneous activity to discriminate patients from normal controls. Finally, we discuss current challenges and potential research directions to further elucidate the clinical use of spontaneous brain activity in neuropsychiatric disorders.

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“…During the resting state, regions exhibiting higher ReHo [3] and ALFF [6,7] than other regions are in line with the location of the default mode network and have the highest metabolic rate as measured by positron emission tomography. These two methods have already been used to explore the functional abnormalities in many brain disorders such as Alzheimer's disease [9,10] and schizophrenia [11,12] . Of note, both ReHo and ALFF have been used in ADHD studies.…”

Section: Introductionmentioning

confidence: 99%

Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

et al. 2013

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Regional homogeneity (ReHo) and the amplitude of low-frequency fl uctuation (ALFF) are two approaches to depicting different regional characteristics of resting-state functional magnetic resonance imaging (RS-fMRI) data. Whether they can complementarily reveal brain regional functional abnormalities in attention-defi cit/hyperactivity disorder (ADHD) remains unknown. In this study, we applied ReHo and ALFF to 23 medication-naïve boys diagnosed with ADHD and 25 age-matched healthy male controls using whole-brain voxel-wise analysis. Correlation analyses were conducted in the ADHD group to investigate the relationship between the regional spontaneous brain activity measured by the two approaches and the clinical symptoms of ADHD. We found that the ReHo method showed widely-distributed differences between the two groups in the fronto-cingulo-occipitocerebellar circuitry, while the ALFF method showed a difference only in the right occipital area. When a larger smoothing kernel and a more lenient threshold were used for ALFF, more overlapped regions were found between ALFF and ReHo, and ALFF even found some new regions with group differences. The ADHD symptom scores were correlated with the ReHo values in the right cerebellum, dorsal anterior cingulate cortex and left lingual gyrus in the ADHD group, while no correlation was detected between ALFF and ADHD symptoms. In conclusion, ReHo may be more sensitive to regional abnormalities, at least in boys with ADHD, than ALFF. And ALFF may be complementary to ReHo in measuring local spontaneous activity. Combination of the two may yield a more comprehensive pathophy-siological framework for ADHD.

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Regional coherence changes in the early stages of Alzheimer’s disease: A combined structural and resting-state functional MRI study

Cited by 492 publications

References 60 publications

Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study

Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

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