Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

An, Li; Cao, Qingjiu; Sui, Manqiu; Sun, Li; Zou, Qihong; Zang, Yu‐Feng; Wang, Yufeng

doi:10.1007/s12264-013-1353-8

Cited by 99 publications

(78 citation statements)

References 45 publications

(65 reference statements)

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“…ALFF and ReHo analyses have been used to investigate the intrinsic neuropathology of various mental disorders (17,26,28,29). These two methods are based on different neurophysiology mechanisms, with ALFF analysis demonstrating neural intensity and ReHo analysis demonstrating neural coherence.…”

Section: Discussionmentioning

confidence: 99%

“…ALFF measures the intensity of neural activity at the single-voxel level (15), whereas ReHo measures the neural synchronization of a given voxel with its neighboring voxels (16). A previous study indicated that ReHo may be more sensitive than ALFF for detecting regional abnormalities and that ALFF may be complementary to ReHo for measuring global spontaneous activity (17). Therefore, the combination of these two methods may provide more information about the pathophysiological framework in the human brain than either method alone (17).…”

mentioning

confidence: 99%

“…A previous study indicated that ReHo may be more sensitive than ALFF for detecting regional abnormalities and that ALFF may be complementary to ReHo for measuring global spontaneous activity (17). Therefore, the combination of these two methods may provide more information about the pathophysiological framework in the human brain than either method alone (17).…”

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confidence: 99%

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Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study

et al. 2014

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Previous research has shown that type 2 diabetes mellitus (T2DM) is associated with an increased risk of cognitive impairment. Patients with impaired cognition often show decreased spontaneous brain activity on resting-state functional magnetic resonance imaging (rs-fMRI). This study used rs-fMRI to investigate changes in spontaneous brain activity among patients with T2DM and to determine the relationship of these changes with cognitive impairment. T2DM patients (n = 29) and age-, sex-, and education-matched healthy control subjects (n = 27) were included in this study. Amplitude of lowfrequency fluctuation (ALFF) and regional homogeneity (ReHo) values were calculated to represent spontaneous brain activity. Brain volume and cognition were also evaluated among these participants. Compared with healthy control subjects, patients with T2DM had significantly decreased ALFF and ReHo values in the occipital lobe and postcentral gyrus. Patients performed worse on several cognitive tests; this impaired cognitive performance was correlated with decreased activity in the cuneus and lingual gyrus in the occipital lobe. Brain volume did not differ between the two groups. The abnormalities of spontaneous brain activity reflected by ALFF and ReHo measurements in the absence of structural changes in T2DM patients may provide insights into the neurological pathophysiology underlying diabetes-associated cognitive decline.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study

et al. 2014

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“…It is widely used in the study of local and global brain activity [8,9]. On the one hand, many rsfMRI studies have applied amplitude of low-frequency fluctuation (ALFF) [10], fractional amplitude of low frequency fluctuation (fALFF) [11], and regional homogeneity (ReHo) [12] into investigating local brain activity in ADHD patients. ALFF reflects the degree of spontaneous activity at each voxel in the light of the level of oxygen content [13].…”

Section: Introductionmentioning

confidence: 99%

“…For example, An et al [12] compare ALFF and ReHo of 23 medicationnaïve boys with ADHD coupled with 25 age-matched controls, and finds that the abnormal brain activity of ADHD patients mainly occurs in fronto-cingulo-occipito-cerebellar areas. In a study on 46 children with ADHD, Shang et al [18] explore the differential effects of methylphenidate and atomoxetine on intrinsic brain activity, including fALFF and ReHo which are quantified via rsfMRI at baseline and week 12.…”

Section: Introductionmentioning

confidence: 99%

Different Developmental Pattern of Brain Activities in ADHD: A Study of Resting-State fMRI

et al. 2018

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There are distinct symptoms for attention deficit hyperactivity disorder (ADHD) at different ages. To explore the developmental mechanism of ADHD from childhood to adolescence, patients from different age groups with ADHD drawn from a large dataset should be investigated. In this study, we hypothesized that there are significant differences in the developmental patterns of local and global brain activities between ADHD and typically developing (TD) individuals. Three voxel-based measurements and the functional connectivity (FC) of the brain networks were extracted from resting-state functional magnetic resonance imaging (fMRI) of both ADHD and TD participants 7–16 years of age. The topological properties of brain networks in both groups were also analyzed, including hubs, hemispheric symmetry, together with local and global efficiency. The results showed, from the local perspective, that the ADHD group had abnormal amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, and regional homogeneity in the medial orbital frontal cortex, anterior cingulate cortex, postcentral gyrus, thalamus, precuneus, and cerebellum compared with the TD group. From the global perspective, the aberrant FC between multiple networks, such as the default mode network (DMN), the attention network, and the executive control network, might directly contribute to symptom differences in childhood and adolescence in ADHD patients. Finally, from the developmental perspective, there was delayed maturation of brain networks in the ADHD group, especially in the DMN. Overall, we presented the differences in brain networks between the ADHD and TD group from multiple perspectives and demonstrated the developmental abnormality of brain networks in ADHD patients, contributing to the study of the etiology of ADHD.

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Dynamic changes in thalamic connectivity following stress and its association with future depression severity

Zhang

Steffens

et al. 2019

Brain and Behavior

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IntroductionTracking stress‐induced brain activity and connectivity dynamically and examining activity/connectivity‐associated recovery ability after stress might be an effective way of detecting stress vulnerability.MethodsUsing two widely used stress paradigms, a speech task (social stress) and a mathematical calculation task (mental loading stress), we examined common changes in regional homogeneity (ReHo) and functional connectivity (FC) before, during, and after the two stressful tasks in thirty‐nine college students. A counting breath relaxation task was employed as a contrast task. ReHo and FC were compared between subjects with higher versus lower depression symptoms (assessed by the Beck Depression Inventory, BDI). We developed a recovery index (RI) based on dynamic changes of ReHo/FC to evaluate individuals' ability to recover from a stressful state. To assess RI's usefulness in predicting future depression severity, BDI was also measured at one‐year follow‐up.ResultsOur results revealed a ReHo decrease after both stressful tasks and a ReHo increase after the relaxation task in bilateral thalamus. The ReHo decrease after both stressful tasks was more significant in the higher BDI than the lower BDI group. Higher ReHo RI of the right thalamus in the higher BDI groups was significantly correlated with lower BDI severity at one‐year follow‐up. Bilateral thalamus also showed increased FC with the default mode network and decreased FC with the executive control network after the stressful tasks.ConclusionThese findings highlight the importance of tracking resting activity and connectivity of thalamus dynamically for detecting stress vulnerability.

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Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

Cited by 99 publications

References 45 publications

Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study

Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study

Different Developmental Pattern of Brain Activities in ADHD: A Study of Resting-State fMRI

Dynamic changes in thalamic connectivity following stress and its association with future depression severity

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