1988
DOI: 10.1016/0165-4608(88)90054-4
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Regional chromosome localization of human papillomavirus intergration sites near fragile sites, oncogenes, and cancer chromosome breakpoints

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Cited by 89 publications
(52 citation statements)
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“…This strongly suggests that integration at those particular sites might have conferred some growth advantages to the cells and might have thus been crucial in their immortalization and their selection. In agreement with our results, in situ hybridization analyses on chromosomes have described HPV-16 or -18 integrated at a single site within cervical carcinomas [30] or cervical carcinoma cells such as SW756 [31], SiHa [32] or C4-I [33] cell lines, even though HeLa and Caski cells were shown to harbor HPV-18 and HPV-16 respectively at several distinct sites [32,34,35]. From those localization studies, it appeared that HPV integration sites were frequently mapped in regions containing oncogenes or fragile sites [10,11].…”
Section: Discussionsupporting
confidence: 81%
“…This strongly suggests that integration at those particular sites might have conferred some growth advantages to the cells and might have thus been crucial in their immortalization and their selection. In agreement with our results, in situ hybridization analyses on chromosomes have described HPV-16 or -18 integrated at a single site within cervical carcinomas [30] or cervical carcinoma cells such as SW756 [31], SiHa [32] or C4-I [33] cell lines, even though HeLa and Caski cells were shown to harbor HPV-18 and HPV-16 respectively at several distinct sites [32,34,35]. From those localization studies, it appeared that HPV integration sites were frequently mapped in regions containing oncogenes or fragile sites [10,11].…”
Section: Discussionsupporting
confidence: 81%
“…Unlike multicellular organisms, the early two-cell embryo either had only two copies of the genome that became disrupted by the HPV DNA or it lacked the necessary repair mechanism to correct for the integrated HPV DNA. The sites for HPV DNA integration into the host genome have been reported to be near oncogenes (27) causing transformation of cells, or at the chromosomal fragile site (28)(29)(30)(31)(32) at 3p14 (31,33) and the FRA8C site at 8q24 (34) resulting in gene interruption and loss of chromosome heterozygosity (24,35). Indirect evidence linking HPV infection and embryo demise would be the prevalence of HPV infection in the infertile population.…”
Section: Discussionmentioning
confidence: 99%
“…In situ hybridization using HPV probes provides a rough estimate on the chromosomal localization, but does not allow ®ne mapping or even gathering sequence information (Cannizzaro et al, 1988;Mincheva et al, 1987). PCR techniques were used to amplify genomic areas containing integrated HPV sequences employing either ALU sequences (Carmody et al, 1996) or speci®c restriction sites (Thorland et al, 2000) as primer binding sites for the¯anking cellular sequences.…”
Section: Discussionmentioning
confidence: 99%