Regional Assessment of Cone System Function Following Uncomplicated Retinal Detachment Surgery

Montrone, L.; Ziccardi, Lucia; Stifano, G.; Piccardi, Marco; Molle, Fernando; Focosi, F.; Fadda, Antonello; Falsini, Benedetto

doi:10.1007/s10633-005-7554-3

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…Previous studies have suggested that retinal detachment may have different magnitudes of effect on the scotopic versus photopic ERG responses. [ 14 15 ] However, in this study, we did not observe a difference in the magnitude of dysfunction between the rod- and cone-driven pathways, suggesting that both subsets of photoreceptors are similarly affected.…”

Section: Discussioncontrasting

confidence: 59%

Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment

Lin

Sein

Stavern

et al. 2018

J Ophthalmic Vis Res

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Purpose:To determine 1) which components of retinal function are impaired after rhegmatogenous retinal detachment, 2) which outer retinal pathways (rod- or cone-driven) are more severely affected, and 3) whether there is concomitant inner retinal dysfunction.Methods:We conducted a prospective observational study in a large academic institution. We performed preoperative electroretinography on eight patients to assess outer and inner retinal function. In all cases, a comparison between the eye with the detached retina and the control fellow eye was made.Results:Eyes with a detached retina had significantly lower a-wave and b-wave amplitudes with respect to both rod- and cone-dominated testing parameters (P < 0.05) and reduced 30 Hz flicker responses compared to fellow eyes (P < 0.05); the effect size was similar for all significantly reduced parameters (r~0.6). There were no significant differences between eyes with detached retinas and control fellow eyes with respect to b/a-wave ratios, a-wave latencies, or b-wave latencies.Conclusion:Patients with rhegmatogenous retinal detachment have preoperative outer retinal dysfunction equally affecting both rod- and cone-driven pathways, and they have minimal inner retinal dysfunction.

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Section: Discussioncontrasting

confidence: 59%

Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment

Lin

Sein

Stavern

et al. 2018

J Ophthalmic Vis Res

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“…Cone system dysfunction may still be detected even long intervals after retinal reattachment, independent of the presence of a preoperative macular RD [23]. It also has been shown that there is a significant correlation between outer nuclear layer (ONL) cell count and flicker ERG amplitude in the reattached retina [24].…”

Section: Discussionmentioning

confidence: 99%

Electroretinogram changes after scleral buckling surgery of retinal detachment

Gong

Sun

et al. 2008

Doc Ophthalmol

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After reattachment of the retina, visual function showed dramatic improvement 1 month after the surgery. The postreceptoral responses recovered more than the a-wave. The rod system recovered more quickly and completely than the cone system during the follow-up period. The incomplete recovery observed by using ERGs indicates that there is irreversible damage that likely occurs following retinal detachment and surgery.

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“…Although we could not assess cone functionality using electrophysiology, this deserves further explorations. Indeed, previous electrophysiological studies of RD human eyes have reported reduced amplitudes and increased latencies compared to normal values, in full filed electroretinograms (ERGs) [31], focal ERGs [32] or multifocal ERGs [33], with evidence for retinal dysfunction due to outer retinal alterations in primary macula-off RD.…”

Section: Discussionmentioning

confidence: 99%

Increased intravitreal glucose in rhegmatogenous retinal detachment

Arndt

Hubault

Hayate

et al. 2022

Eye

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Altered glucose metabolism, along with low-grade inflammation, has been proposed to be involved in retinal detachment (RD)-induced cone loss. Here, we assessed intravitreal glucose and cytological profile in patients with macula-off RD. METHODS: Glucose concentration was analysed in vitreous samples from 137 non-diabetic patients undergoing vitrectomy for either primary macula-off RD (n = 73) or epiretinal membrane (ERM; n = 64). Cellularity was assessed in vitreous cytospin preparations by a semi-quantitative immunostaining approach. RESULTS: Intravitreal glucose concentration was higher in the RD group (2.28 mmol.L-1 n =73 vs 1.6 mmol.L-1 n = 64; p < 0.0001). Overall cellularity and density of macrophages were significantly higher in the vitreous of RD patients (respectively p = 0.003 and p < 0.0001). Among the RD patients, intravitreal glucose concentration correlated with macrophages density (p = 0.002): its levels remained significantly higher in eyes in which macrophages were innumerable compared to lower macrophages densities RD eyes (p = 0.0095). CONCLUSIONS: We observed a strong relationship between intravitreal glucose concentration and vitreous macrophage density. Additional indicators for vitreous glycation and low-grade inflammation should be further studied.

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Regional Assessment of Cone System Function Following Uncomplicated Retinal Detachment Surgery

Cited by 5 publications

References 12 publications

Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment

Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment

Electroretinogram changes after scleral buckling surgery of retinal detachment

Increased intravitreal glucose in rhegmatogenous retinal detachment

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