Region-Wise Distribution of High-Risk Human Papillomavirus Types in Squamous Cell Carcinomas of the Cervix in India

Pillai, Radhakrishna; Babu, Janaki M.; Jissa, V T; Lakshmi, S.; Chiplunkar, Shubhada V.; Patkar, Meena; Tongaonkar, Hemant; Reddy, K Bhaskar; Chakka, Kumar; Siddiqui, M Asif A; Roychoudury, Soma; Abraham, Priya; Peedicayil, Abraham; Gnanamony, Manu; Subashini, J.; Ram, Thomas Samuel; Dey, Bindu; Singh, Neeta; Singh, Archana; Jain, Shreyans; Jayshree, R. S.

doi:10.1111/igc.0b013e3181e02fe0

Cited by 23 publications

(15 citation statements)

References 19 publications

(16 reference statements)

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“…Further observing the increasing trend towards prevalence of different high risk groups other than 16/18 in both Kolkata and Manipur, we also agree according to Pillai et al 2010 that considering the prevalence of other high risk groups circulating among these two groups of population, other than the prophylactic HPV-16/18-L1 vaccine a broad-based vaccine approach would be appropriate for India. At present there are two HPV vaccines under trial in India: Gardasil (Donated by Merck & Co., Inc.) and Cervarix (GlaxoSmithKline).…”

Section: Discussionsupporting

confidence: 82%

“…Another study among the young married women from North India had identified HPV16 as the commonest high-risk type (3%) followed by HPV52 (1.2%) and HPV51 (0.8%) [3]. Recent study from four different regions across India also showed that other than the prevalent HR (High Risk) variant 16 followed by 18 (79.6%), there has also been prevalence of other high risk types (12.4%) such as 45, 73, 31, 56, 52, 58, 59, 33, 68, 51, 35, 26, and 39 [4].…”

Section: Introductionmentioning

confidence: 99%

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Genotypic Distribution of Different Variants of Oncogenic Human Papilloma Virus (HPV) among the Sexually Active HIV-1 Positive Female Population from Manipur, India

Mullick¹,

Sengupta²,

Sarkar³

et al. 2012

WJA

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A total of 531 sexually active female populations from Manipur (north-eastern India), was chosen for this study. Out of 531 females from Manipur, 111 (20.9%) were HIV positive and 420 were HIV negative (79%). PCR amplification of the MY region of the HPV L1 gene using consensus MY09/11 primer showed 3.7% positivity in Manipur. Interestingly HPV infection among the HIV infected population from Manipur was found to be higher (9%) compared to the non HIV infected population from Manipur (3.7%). Further, single PCR for detecting the 16/18 genotypes and multiplex PCR for the other high risk groups showed equal prevalence of 16 and 18 and other high risk groups (1.3% each) in Manipur. This result was further confirmed by the sequencing and phylogenetic analysis. Thus, our study showed fairly high HPV prevalence rate among the HIV infected population compared to the non HIV cases in Manipur and also equal prevalence of 16/18 genotypes with other high risk groups. According to our knowledge this is the first kind of a genotypic study among the HPV-HIV co-infected population from northeastern states of India.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Genotypic Distribution of Different Variants of Oncogenic Human Papilloma Virus (HPV) among the Sexually Active HIV-1 Positive Female Population from Manipur, India

Mullick¹,

Sengupta²,

Sarkar³

et al. 2012

WJA

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Section: Discussionmentioning

confidence: 99%

“…In Kolkata, 59–74% of ICC cases are infected with HPV 16 and 2–13.9% cases infected with HPV 18 [7, 18]. Reports from south India showed HPV 16 and HPV18 accounts for 58–69% and 5–19.4% of ICC cases respectively [16, 18]. In a similar study from Delhi (north India) reported that HPV 16 and 18 contributing 73.6 and 14.2% cases of cervical carcinoma [19].…”

Section: Discussionmentioning

confidence: 99%

HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India

et al. 2017

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BackgroundConsidering the limited cross protection offered by the current HPV vaccines, understanding the HPV genotype distribution among the different population is essential in predicting the efficacy of current vaccine and devising new vaccine strategy. The present work aimed at investigating the HPV genotypes distribution among women with and without cervical carcinoma in Odisha, Eastern India.MethodsA total of 607 participants have been enrolled between January 2014 and June 2016. L1-PCR, sequencing, and E6/E7 nested multiplex type- specific PCR were performed for HPV detection and genotyping. Cytological distribution of 440 cases includes invasive cervical carcinoma or ICC (n = 210), inflammatory smear (n = 162), normal cytology (n = 68). Statistical analyses were performed by using SPSS version 20.0 software and MediCal version 14.10.2(7). A p-value of ≤ 0.05 was considered statistically significant.ResultsThe overall prevalence of HPV infection was (359/595) 60.33%. Prevalence of HPV infection was 93.80% (197/210) in invasive cervical cancer (ICC) cases, 54.32% (88/162) in inflammatory smear and 19.11% (13/68) in normal cervical cytology. The most prevalent genotype was HPV16 (87.28%) followed by HPV18 (24.56%) and HPV 51(3.46%). The overall prevalence of single type was 76.58% and highest (78.9%) among ICC cases. The most frequent genotype combination after HPV16 + 18(9.4%) was HPV16 + 66 + 68(2.7%) which was frequently observed in inflammatory cytology. Age > 45years, parity ≥3, low socio-economic condition, rural residential area and post menopause state were significantly associated with HPV infection. Multiple infections did not have a significant association with any of the clinicopathological variables (stage, LN metastasis, cell type) except tumor size ≥ 2cm in ICC cases. The impact of 2v, 4v, and 9v vaccines in preventing cervical cancer in Odisha were 89.99, 91.65, and 92.16% respectively.ConclusionThis data would help planning an appropriate strategy for disease monitoring and provides baseline data for post-vaccination surveillance in the region. The nonavalent vaccine would be significant in preventing cervical carcinoma in Odisha. Hence an effective vaccination program based on regional HPV epidemiological profile along with the cervical cancer screening is necessary to reduce the cervical cancer burden in India.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2136-4) contains supplementary material, which is available to authorized users.

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“…The lag period between infection with oncogenic HPV and invasive cervical cancer is 15-20 years [88,89]. In India, the most common (80%) oncogenic types are HPV types 16 and 18; with HPV 16 predominating (80%-90%) [90,91].…”

Section: Hpv Vaccinesmentioning

confidence: 99%

Update on Available Vaccines in India: Report of the APPA VU 2010: I

Karande

2011

Indian J Pediatr

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The Asia Pacific Pediatric Association Vaccinology Update 2010 was held in Mumbai on November 13-14, 2010 to discuss the latest information on burden of infectious diseases, recent developments in vaccines and their impact on immunization practices against infectious diseases occurring in Indian children. During the conference the importance of including conjugate Haemophilus influenzae type b vaccine and anti-rabies vaccines in routine immunization was stressed. Also, the need for giving a second dose of measles mumps rubella vaccine at school entry; and the need for a two-dose varicella vaccine regimen (first dose at 12-15 months of age and a second dose at age 4-6 years) was elucidated. Information related to vaccines which have become available in India in recent years, namely, inactivated poliovirus vaccine; diphtheria, tetanus, acellular pertussis (DTaP) vaccine; conjugate pneumococcal vaccine; rotavirus vaccines; H1N1 vaccines; live attenuated hepatitis A virus vaccine; oral cholera vaccine; tetanus, reduced-dose diphtheria, acellular pertussis (Tdap) vaccine; and human papillomavirus vaccines were discussed.

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Region-Wise Distribution of High-Risk Human Papillomavirus Types in Squamous Cell Carcinomas of the Cervix in India

Cited by 23 publications

References 19 publications

Genotypic Distribution of Different Variants of Oncogenic Human Papilloma Virus (HPV) among the Sexually Active HIV-1 Positive Female Population from Manipur, India

Genotypic Distribution of Different Variants of Oncogenic Human Papilloma Virus (HPV) among the Sexually Active HIV-1 Positive Female Population from Manipur, India

HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India

Update on Available Vaccines in India: Report of the APPA VU 2010: I

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