Region‐specific disturbed iron distribution in early idiopathic <scp>P</scp>arkinson's disease measured by quantitative susceptibility mapping

He, Naying; Ling, Huawei; Ding, Bei; Huang, Juan; Zhang, Yong; Zhang, Zhongping; Liu, Chunlei; Chen, Kemin; Yan, Fuhua

doi:10.1002/hbm.22928

Cited by 172 publications

(224 citation statements)

References 82 publications

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“…Related studies have found regional susceptibility or R2* differences in single individual anatomical structures such as the putamen, caudate nucleus or the globus pallidus [17,34,35]. Extending these findings, we were able to demonstrate a more widespread involvement of the deep gray matter structures by applying QSM, including the substantia nigra, nucleus ruber, thalamus, and globus pallidus.…”

Section: Discussionsupporting

confidence: 77%

Quantitative Susceptibility Mapping in Parkinson's Disease

et al. 2016

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BackgroundQuantitative susceptibility mapping (QSM) and R2* relaxation rate mapping have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson’s disease (PD). However, the findings in other subcortical deep gray matter nuclei are converse and the sensitivity of QSM and R2* for morphological changes and their relation to clinical measures of disease severity has so far been investigated only sparsely.MethodsThe local ethics committee approved this study and all subjects gave written informed consent. 66 patients with idiopathic Parkinson’s disease and 58 control subjects underwent quantitative MRI at 3T. Susceptibility and R2* maps were reconstructed from a spoiled multi-echo 3D gradient echo sequence. Mean susceptibilities and R2* rates were measured in subcortical deep gray matter nuclei and compared between patients with PD and controls as well as related to clinical variables.ResultsCompared to control subjects, patients with PD had increased R2* values in the substantia nigra. QSM also showed higher susceptibilities in patients with PD in substantia nigra, in the nucleus ruber, thalamus, and globus pallidus. Magnetic susceptibility of several of these structures was correlated with the levodopa-equivalent daily dose (LEDD) and clinical markers of motor and non-motor disease severity (total MDS-UPDRS, MDS-UPDRS-I and II). Disease severity as assessed by the Hoehn & Yahr scale was correlated with magnetic susceptibility in the substantia nigra.ConclusionThe established finding of higher R2* rates in the substantia nigra was extended by QSM showing superior sensitivity for PD-related tissue changes in nigrostriatal dopaminergic pathways. QSM additionally reflected the levodopa-dosage and disease severity. These results suggest a more widespread pathologic involvement and QSM as a novel means for its investigation, more sensitive than current MRI techniques.

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Section: Discussionsupporting

confidence: 77%

Quantitative Susceptibility Mapping in Parkinson's Disease

et al. 2016

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“…Following an exhaustive examination of the contents, 224 articles were excluded according to the selection criteria detailed in the method section. Of the 33 articles being selected that report iron content (summarized in Table 1), 11 of them employed postmortem analyses2491011121314151617, 14 were measured by R2* 318192021222324252627282930 and 8 by MRI relaxometry SWI3132333435363738. The disease comorbidity and diagnostic performance of the cohorts of these 33 studies are summarized in Table S1.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

Wang

Zhuang

Zhu

et al. 2016

Sci Rep

164

121

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Brain iron levels in patients of Parkinson’s disease (PD) are usually measured in postmortem samples or by MRI imaging including R2* and SWI. In this study we performed a meta-analysis to understand PD-associated iron changes in various brain regions, and to evaluate the accuracy of MRI detections comparing with postmortem results. Databases including Medline, Web of Science, CENTRAL and Embase were searched up to 19th November 2015. Ten brain regions were identified for analysis based on data extracted from thirty-three-articles. An increase in iron levels in substantia nigra of PD patients by postmortem, R2* or SWI measurements was observed. The postmortem and SWI measurements also suggested significant iron accumulation in putamen. Increased iron deposition was found in red nucleus as determined by both R2* and SWI, whereas no data were available in postmortem samples. Based on SWI, iron levels were increased significantly in the nucleus caudatus and globus pallidus. Of note, the analysis might be biased towards advanced disease and that the precise stage at which regions become involved could not be ascertained. Our analysis provides an overview of iron deposition in multiple brain regions of PD patients, and a comparison of outcomes from different methods detecting levels of iron.

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“…Devos, et al have recently reported very encouraging results showing that DFP improves PD motor performance and reduces nigral R2* values on GRE MRI, suggesting that DFP can be the first disease-modifying therapy for PD (127). Because QSM is superior to R2* for evaluating nigral iron (131,132,134,135,145), an important potential application of QSM in PD is to measure DFP's effectiveness of target-engagement in clinical trials.…”

Section: Clinical Applications Enabled By Qsm Biometal Imagingmentioning

confidence: 99%

Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care

Wang

Spincemaille

Liu

et al. 2017

Magnetic Resonance Imaging

205

194

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Quantitative susceptibility mapping (QSM) has enabled MRI of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. QSM technology may be regarded to be sufficiently developed and validated to warrant wide dissemination for clinical applications of imaging isotropic susceptibility, which is dominated by metals in tissue, including iron and calcium. These biometals are highly regulated as vital participants in normal cellular biochemistry, and their dysregulations are manifested in a variety of pathologic processes. Therefore, QSM can be used to assess important tissue functions and disease. To facilitate QSM clinical translation, this review aims to organize pertinent information for implementing a robust automated QSM technique in routine MRI practice and to summarize available knowledge on diseases for which QSM can be used to improve patient care. In brief, QSM can be generated with postprocessing whenever gradient echo MRI is performed. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians may consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols.

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Region‐specific disturbed iron distribution in early idiopathic Parkinson's disease measured by quantitative susceptibility mapping

Cited by 172 publications

References 82 publications

Quantitative Susceptibility Mapping in Parkinson's Disease

Quantitative Susceptibility Mapping in Parkinson's Disease

Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care

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