Regioisomeric acylated polyhydroxy triterpenoids from the stems of Barringtonia racemosa

Annam, Suresh Chandra Venkata Appa Rao; Ankireddy, Madhu; Gowri, P. Mangala; Raju, Tuniki Venugopal; Pardhasaradhi, B.V.V.

doi:10.1016/j.phytol.2015.08.007

Cited by 8 publications

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References 10 publications

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“…Indeed, the various pharmacological activities reported for some pentacyclic triterpenoids like anticancer, have been attributed to the presence of the hydroxyl group. This was evident by racemosol, a polyhydroxy triterpenoid that showed significant anticancer activities against human cancer cells [ 5 ]. Other studies have further shown that the activities of hydroxylated pentacyclic triterpenoids are significantly affected by the number of hydroxyl groups contained in ring A.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species

et al. 2020

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The genus Euphorbia is one of the largest genera in the spurge family, with diversity in range, distribution, and morphology. The plant species in this genus are widely used in traditional medicine for the treatment of diseases, ranging from respirational infections, body and skin irritations, digestion complaints, inflammatory infections, body pain, microbial illness, snake or scorpion bites, pregnancy, as well as sensory disorders. Their successes have been attributed to the presence of diverse phytochemicals like polycyclic and macrocyclic diterpenes with various pharmacological properties. As a result, Euphorbia diterpenes are of interest to chemists and biochemists with regard to drug discovery from natural products due to their diverse therapeutic applications as well as their great structural diversity. Other chemical constituents such as triterpenoids have also been reported to possess various pharmacological properties, thus supporting the traditional uses of the Euphorbia species. These triterpenoids can provide potential leads that can be developed into pharmaceutical compounds for a wide range of medicinal applications. However, there are scattered scientific reports about the anticancer activities of these constituents. Harnessing such information could provide a database of bioactive pharmacopeia or targeted scaffolds for drug discovery. Therefore, this review presents an updated and comprehensive summary of the ethnomedicinal uses, phytochemistry, and the anticancer activities of the triterpenoids of Euphorbia species. Most of the reported triterpenoids in this review belong to tirucallane, cycloartanes, lupane, oleanane, ursane, and taraxane subclass. Their anticancer activities varied distinctly with the majority of them exhibiting significant cytotoxic and anticancer activities in vitro. It is, therefore, envisaged that the report on Euphorbia triterpenoids with interesting anticancer activities will form a database of potential leads or scaffolds that could be advanced into the clinical trials with regard to drug discovery.

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Section: Introductionmentioning

confidence: 99%

A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species

et al. 2020

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“…New oleanane esters from Barringtonia racemosa include racemosol B 605 and isoracemosol B 606 (ref. 259) and racemosols C 607 and D 608. 260 Other new oleanane esters include the formyl ester of b-amyrin from Dichrocephala benthamii, 261 the caffeoyl esters 609 and 610 from Waltheria indica 262 and the coumaroyl ester 611 from Astilbe rivularis.…”

Section: The Lupane Groupmentioning

confidence: 99%