A pentacyclic triterpene derivative possessing polyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygen species-dependent NF-κB pathway

Huang, Ri-Zhen; Jin, Le; Wang, Chun-Gu; Xu, Xiaoyan; Du, Ying; Liao, Na; Ji, Min; Liao, Zhi‐Xin; Wang, Hengshan

doi:10.1016/j.ejphar.2018.08.032

Cited by 12 publications

(10 citation statements)

References 52 publications

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“…In human colonic adenocarcinoma cells, koumine can inhibit the mitochondrial membrane potential while enhancing the production of ROS [23]. Within human cervical cancer HeLa cells, studies have found that koumine promotes the apoptosis and cycle arrest of cancer cells by suppressing ROS-dependent NF-κB pathway [24]. Interestingly, koumine reduces proinflammatory factor production within mouse macrophages via inhibiting ERK/p38 MAPK phosphorylation and the NF-κB pathway [25].…”

Section: Introductionmentioning

confidence: 99%

Koumine Promotes ROS Production to Suppress Hepatocellular Carcinoma Cell Proliferation Via NF-κB and ERK/p38 MAPK Signaling

Yuan

Liang

et al. 2019

Biomolecules

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In the past decades, hepatocellular carcinoma (HCC) has been receiving increased attention due to rising morbidity and mortality in both developing and developed countries. Koumine, one of the significant alkaloidal constituents of Gelsemium elegans Benth., has been regarded as a promising anti-inflammation, anxiolytic, and analgesic agent, as well as an anti-tumor agent. In the present study, we attempted to provide a novel mechanism by which koumine suppresses HCC cell proliferation. We demonstrated that koumine might suppress the proliferation of HCC cells and promote apoptosis in HCC cells dose-dependently. Under koumine treatment, the mitochondria membrane potential was significantly decreased while reactive oxygen species (ROS) production was increased in HCC cells; in the meantime, the phosphorylation of ERK, p38, p65, and IκBα could all be inhibited by koumine treatment dose-dependently. More importantly, the effects of koumine upon mitochondria membrane potential, ROS production, and the phosphorylation of ERK, p38, p65, and IκBα could be significantly reversed by ROS inhibitor, indicating that koumine affects HCC cell fate and ERK/p38 MAPK and NF-κB signaling activity through producing excess ROS. In conclusion, koumine could inhibit the proliferation of HCC cells and promote apoptosis in HCC cells; NF-κB and ERK/p38 MAPK pathways could contribute to koumine functions in a ROS-dependent manner.

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Section: Introductionmentioning

confidence: 99%

Koumine Promotes ROS Production to Suppress Hepatocellular Carcinoma Cell Proliferation Via NF-κB and ERK/p38 MAPK Signaling

Yuan

Liang

et al. 2019

Biomolecules

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“…In addition, triterpenoids have been strongly linked to anti-inflammatory properties and drug resistance mitigation. It effectively inhibits NF-B activation, induces apoptosis, and suppresses inflammation, hence playing a crucial role in anti-inflammatory disorders (Huang et al 2018 ). Furthermore, triterpenoids have played a significant role in breast cancer chemoprevention and treatment.…”

Section: Phytochemicals Extracted From C Umbellatamentioning

confidence: 99%

Chimaphila umbellata; a biotechnological perspective on the coming-of-age prince’s pine

Ali,

Khan,

Khan

et al. 2023

Phytochem Rev

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Chimaphila umbellata has been studied for almost two centuries now, with the first paper exploring the phytochemistry of the plant published in 1860. Almost all contemporary studies focus on the biotechnological advances of C. umbellata including its utilization as a natural alternative in the cosmetic, food, biofuel, and healthcare industry, with a special focus on its therapeutic uses. This literature review critically investigates the significance and applications of secondary metabolites extracted from the plant and presses on the biotechnological approaches to improve its utilization. C. umbellata is home to many industrially and medicinally important phytochemicals, the majority of which belong to phenolics, sterols, and triterpenoids. Other important compounds include 5-hydroxymethylfurfural, isohomoarbutin, and methyl salicylate (the only essential oil of the plant). Chimaphilin is the characteristic phytochemical of the plant. This review focuses on the phytochemistry of C. umbellata and digs into their chemical structures and attributes. It further discusses the challenges of working with C. umbellata including its alarming conservation status, problems with in-vitro cultivation, and research and development issues. This review concludes with recommendations based on biotechnology, bioinformatics, and their crucial interface.

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“…Pentacyclic triterpenes with a polyhydroxylated A ring were found to exhibit important biological activities with a potency in direct dependency to the number of hydroxyl groups; this is presumably due to the involvement of the hydroxyl group in the antitumor and anti-inflammatory effect of the respective pentacyclic compound ( 171 ). (1β, 2α, 3β, 19β, 23)-1,2,3,19,23-pentahydroxyolean-12-en-28-oic acid is a new phytochemical compound isolated from Euphorbia sieboldiana C.Morren & Decne., identified as a strong inhibitor of cervical cancer cells proliferation in a dose- and time-dependent manner; it exerts a selective cytotoxic activity by inducing apoptosis and cell cycle arrest in the G1 phase by inactivating the TNF-α–TAK1–IKK-NF-κB axis and TNF-α–stimulated NF-κB activity and subsequently down-regulating the NF-κB target genes.…”

Section: Triterpenes As Therapeutic Agents In Sex Hormone-dependent Cmentioning

confidence: 99%

“…(1β, 2α, 3β, 19β, 23)-1,2,3,19,23-pentahydroxyolean-12-en-28-oic acid is a new phytochemical compound isolated from Euphorbia sieboldiana C.Morren & Decne., identified as a strong inhibitor of cervical cancer cells proliferation in a dose- and time-dependent manner; it exerts a selective cytotoxic activity by inducing apoptosis and cell cycle arrest in the G1 phase by inactivating the TNF-α–TAK1–IKK-NF-κB axis and TNF-α–stimulated NF-κB activity and subsequently down-regulating the NF-κB target genes. The newly discovered compounds also showed anti-metastasis activity on HeLa cells and further studies revealed that the NF-κB signaling cascade was decreased via ROS generation ( 171 ).…”

Section: Triterpenes As Therapeutic Agents In Sex Hormone-dependent Cmentioning

confidence: 99%

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

et al. 2021

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Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Sex hormone-dependent cancers share a common and rather unique carcinogenesis mechanism involving the active role of endogenous and exogenous sex hormones to maintain high mitotic rates and increased cell proliferation thus increasing the probability of aberrant gene occurrence and accumulation highly correlated with abnormal cell division and the occurrence of malignant phenotypes. Cancer related hormone therapy has evolved, currently being associated with the blockade of other signaling pathways often associated with carcinogenesis and tumor progression in cancers, with promising results. However, despite the established developments, there are still several shortcomings to be addressed. Triterpenes are natural occurring secondary metabolites biosynthesized by various pathways starting from squalene cyclization. Due to their versatile therapeutic potential, including the extensively researched antiproliferative effect, these compounds are most definitely a cornerstone in the research and development of new natural/semisynthetic anticancer therapies. The present work thoroughly describes the ongoing research related to the antitumor activity of triterpenes in sex hormone-dependent cancers. Also, the current review highlights both the biological activity of various triterpenoid compounds and their featured mechanisms of action correlated with important chemical structural features.

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A pentacyclic triterpene derivative possessing polyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygen species-dependent NF-κB pathway

Cited by 12 publications

References 52 publications

Koumine Promotes ROS Production to Suppress Hepatocellular Carcinoma Cell Proliferation Via NF-κB and ERK/p38 MAPK Signaling

Koumine Promotes ROS Production to Suppress Hepatocellular Carcinoma Cell Proliferation Via NF-κB and ERK/p38 MAPK Signaling

Chimaphila umbellata; a biotechnological perspective on the coming-of-age prince’s pine

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

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