Regio‐ and Diastereoselective KMnO<sub>4</sub>/RCO<sub>2</sub>H Mediated Acyloxyarylation of Chalcones – An Indirect α‐Arylation of Chalcones

Adib, Mehdi; Rajai‐Daryasarei, Saideh; Pashazadeh, Rahim; Mahdavi, Mohammad; Madadi, Mozhdeh; Jahani, Mehdi

doi:10.1002/ejoc.201901647

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…Recently, an indirect α‐arylation protocol of chalcones has been disclosed [57] . The protocol started with the preparation of 1‐acyloxy‐3‐oxo‐1,2,3‐triarylpropanes by heating a solution of a chalcone and an arylboronic acid in an aliphatic carboxylic acid at 80 °C.…”

Section: Different α‐Substituted Chalconesmentioning

confidence: 99%

α‐Substituted Chalcones: A Key Review

Al-Rifai

Mubarak

2021

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Chalcones are attractive chemical motifs with various biological activities. Aryl substituted chalcones have been extensively studied and reviewed through the years. However, α‐substituted chalcones have rarely been investigated. Hence, this review highlights the α‐substituted chalcones: their synthetic routes, reported biological activities, and transformations to other organic compounds. To the best of our knowledge, this would be the first comprehensive review about α‐substituted chalcones. α‐Substitution of chalcones represents a promising approach to tune their reactivity since it has a direct influence on their activity as Michael acceptors. Additionally, α‐substitution has its effect on the structure and conformation of chalcones. Altering the reactivity of chalcones by α‐substitution has a great impact on their biological activity.

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Section: Different α‐Substituted Chalconesmentioning

confidence: 99%

α‐Substituted Chalcones: A Key Review

Al-Rifai

Mubarak

2021

ChemistrySelect

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“…The Mn(III)-mediated oxidation of arylboronic acids to aryl radical species and subsequent addition to various unsaturated systems, including arenes, alkenes, unsaturated cyclic compounds, and isocyanides, has been studied intensively in past decades. With isocyanides, the imidoyl radical intermediates that are formed can undergo cascade reactions with various nucleophiles.…”

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confidence: 99%