“…Their versatility has been witnessed in transition-metal-catalyzed isocyanide insertion, 10 isocyanide-based multicomponent reactions, 11 and radical isocyanide chemistry, 12 resulting in the rise of imidoylation, 13 ketenimination, 14 and cyanation. 15–53 Among the innumerable applications of isocyanides, the most striking feature is their ability to act as a “cyano” source, where they show advantages over other sources in being nontoxic, commercially available, easy to handle, and environmentally benign. In general, three types of cyanation with isocyanides have been established.…”