Regenerative hepatology: In the quest for a modern prometheus?

Papatheodoridi, Μargarita; Mazza, Giuseppe; Pinzani, Massimo

doi:10.1016/j.dld.2020.08.001

Cited by 4 publications

(2 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 105 , 106 In addition, the transplanted scaffold can ensure liver mass that will provide functional metabolic support until the recipient’s liver can restore its functions. 92 , 107 , 108 …”

Section: Resection and Partial Hepatectomy Before Transplantationmentioning

confidence: 99%

“…105,106 In addition, the transplanted scaffold can ensure liver mass that will provide functional metabolic support until the recipient's liver can restore its functions. 92,107,108 Aiming to use this approach in the human clinic in the future, this bioengineering strategy can be an efficient tool to increase the limit of liver resections during hepatectomies procedures. 109 Furthermore, the successful results obtained by literature support that acellular liver lobe transplantation can induce liver regeneration and therefore minimize the risk of postoperative liver failure in humans.…”

Section: Resection and Partial Hepatectomy Before Transplantationmentioning

confidence: 99%

See 1 more Smart Citation

Liver scaffolds obtained by decellularization: A transplant perspective in liver bioengineering

2022

View full text Add to dashboard Cite

Liver transplantation is the only definitive treatment for many diseases that affect this organ, however, its quantity and viability are reduced. The study of liver scaffolds based on an extracellular matrix is a tissue bioengineering strategy with great application in regenerative medicine. Collectively, recent studies suggest that liver scaffold transplantation may assist in reestablishing hepatic function in preclinical diseased animals, which represents a great potential for application as a treatment for patients with liver disease in the future. This review focuses on useful strategies to promote liver scaffold transplantation and the main open questions about this context. We outline the current knowledge about ex vivo bioengineered liver transplantation, including the surgical techniques, recipient survival time, scaffold preparation before transplantation, and liver disease models. We also highlight the current limitations and future directions regarding in vivo bioengineering techniques.

show abstract