Liver Regeneration in Acute on Chronic Liver Failure

Blake, Madelyn J.; Steer, Clifford J.

doi:10.1016/j.cld.2023.03.005

Cited by 2 publications

(1 citation statement)

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“…With a broad impact range, miRNAs are crucial regulators in many physiological processes and pathological conditions. They are involved in liver regeneration, metabolism, fibrosis, inflammation, and carcinogenesis, with contributions to the pathogenesis of diseases such as cirrhosis, ACLF, MASLD/MASH, and liver cancer[ 140 - 143 ].…”

Section: Viral Factors Affecting Liver Failurementioning

confidence: 99%

Pathogenesis and clinical features of severe hepatitis E virus infection

Orosz,

Sárvári,

Dernovics

et al. 2024

World J Virol

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The hepatitis E virus (HEV), a member of the Hepeviridae family, is a small, non-enveloped icosahedral virus divided into eight distinct genotypes (HEV-1 to HEV-8). Only genotypes 1 to 4 are known to cause diseases in humans. Genotypes 1 and 2 commonly spread via fecal-oral transmission, often through the consumption of contaminated water. Genotypes 3 and 4 are known to infect pigs, deer, and wild boars, often transferring to humans through inadequately cooked meat. Acute hepatitis caused by HEV in healthy individuals is mostly asymptomatic or associated with minor symptoms, such as jaundice. However, in immunosuppressed individuals, the disease can progress to chronic hepatitis and even escalate to cirrhosis. For pregnant women, an HEV infection can cause fulminant liver failure, with a potential mortality rate of 25%. Mortality rates also rise amongst cirrhotic patients when they contract an acute HEV infection, which can even trigger acute-on-chronic liver failure if layered onto pre-existing chronic liver disease. As the prevalence of HEV infection continues to rise worldwide, highlighting the particular risks associated with severe HEV infection is of major medical interest. This text offers a brief summary of the characteristics of hepatitis developed by patient groups at an elevated risk of severe HEV infection.

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Section: Viral Factors Affecting Liver Failurementioning

confidence: 99%