Regenerative endodontic procedure of an infected immature permanent human tooth: an immunohistological study

Meschi, Nastaran; Hilkens, Petra; Lambrichts, Ivo; Eynde, Kathleen Van den; Mavridou, Athina; Strijbos, Olaf; Ketelaere, Marieke De; Gorp, G. Van; Lambrechts, Paul

doi:10.1007/s00784-015-1555-8

Cited by 53 publications

(58 citation statements)

References 35 publications

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“…Concerning the state of the pulp before the initiation of regenerative treatment, two teeth displayed irreversible pulpitis , nine had pulpal necrosis , and ten had apical periodontitis . Two teeth were completely healthy, and their pulps were extirpated , while one had previously initiated root canal treatment and lacked pulp tissue .…”

Section: Resultsmentioning

confidence: 99%

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Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review

2019

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The aim of this study was to systematically review the histological evidence of the neo-formed tissues inside the root canals of human teeth having previously received regenerative endodontic treatment. An electronic research was performed in the MEDLINE, Web of Science, Scopus and Cochrane Library databases using controlled vocabulary. The retrieved studies were screened by two reviewers according to the predetermined inclusion and extrusion criteria and were full-text-evaluated. Research resulted in 160 studies. Among them, twelve fitted the inclusion criteria and were critically appraised. The tissues formed in the root canals of immature human teeth treated with REP indicate repair or a combination of repair and regeneration. Pulp remnants and healthy periapical tissues seem to improve regeneration. The level of available evidence was low. Further clinical studies are needed in order to establish the appropriate treatment protocol related to the pretreatment status of the dental pulp and the periapical tissues.

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Section: Resultsmentioning

confidence: 99%

“…Then, 43 studies were excluded by title and 32 studies were excluded by abstract. Finally, 12 articles met the inclusion criteria after full‐text evaluation .…”

Section: Resultsmentioning

confidence: 99%

Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review

2019

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“…However, histologic analyses after revitalization show that in some cases healing or repair might take place but not regeneration. Repair is defined as ectopic tissue formation with a partial loss of function with studies reporting the formation of fibrous tissue, cementum or bone inside the root canal (da Silva et al 2010, Wang et al 2010, Martin et al 2014, Meschi et al 2015.…”

Section: Introductionmentioning

confidence: 99%

European Society of Endodontology position statement: Revitalization procedures

et al. 2016

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This position statement represents a consensus of an expert committee convened by the European Society of Endodontology (ESE) on revitalization procedures. The statement is based on current clinical and scientific evidence as well as the expertise of the committee. The goal is to provide suitably trained dentists with a protocol including procedural details for the treatment of immature teeth with pulp necrosis as well as a patient consent form. Revitalization is a biologically based treatment as an alternative to apexification in properly selected cases. Previously published review articles provide more detailed background information and the basis for this position statement (Journal of Endodontics, 39, 2013, S30; Journal of Endodontics, 39, 2013, 319; Journal of Endodontics, 40, 2014, 1045; Dental Traumatology, 31, 2015, 267; International Endodontic Journal, 2015, doi: ). As controlled clinical trials are lacking and new evidence is still emerging, this position statement will be updated at appropriate intervals. This might lead to changes to the protocol provided here.

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“…However, current endodontic interventions, such as root canal treatments, are based on the use of rubber cones and liquid sealants as filling biomaterials that do not promote tissue regeneration (Guldener, ), although regenerative endodontic procedures, such as apexogenesis and maturogenesis, have recently been explored. Newer reports (Meschi et al , ) have demonstrated that regenerative endodontic procedure techniques are not able to induce the regeneration of pulp tissues. Instead, the repair process occurs by the formation of connective tissue but not dental pulp tissue per se .…”

Section: Introductionmentioning

confidence: 99%

Bioactive injectable aggregates with nanofibrous microspheres and human dental pulp stem cells: A translational strategy in dental endodontics

Garzón

Martín-Piedra

Carriel

et al. 2017

J Tissue Eng Regen Med

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Regeneration of the pulp-dentin complex with stem cells is a potential alternative to conventional root canal treatments. Human dental pulp stem cells (hDPSCs) have been extensively studied because of their ability to proliferate and differentiate into mineralized dental and non-dental tissues. Here we combined hDPSCs with two types of injectable poly-L-lactic acid (PLLA) microsphere with a nanofibrous or smooth surface to form bioactive injectable aggregates, and examined their ability to promote pulp regeneration in the root canal in an in vivo model. We investigated the biocompatibility, biosafety and odontogenic potential of fibrous (F-BIM) and smooth bioactive injectable microspheres (S-BIM) in vitro and in vivo. Our results demonstrated that PLLA microspheres and hDPSCs were able to form bioactive injectable aggregates that promoted dentin regeneration in both in vitro and in vivo models. Our results suggest that F-BIM and S-BIM may induce dentinogenesis upon in vivo grafting, and propose that the potential usefulness of the microsphere-hDPSC aggregates described here should be evaluated in clinical settings.

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Regenerative endodontic procedure of an infected immature permanent human tooth: an immunohistological study

Abstract: REP of an immature permanent infected tooth may heal the periapical infection and may result in a combination of regeneration and repair of the pulp-dentin complex.

Cited by 53 publications

References 35 publications

Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review

Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review

European Society of Endodontology position statement: Revitalization procedures

Bioactive injectable aggregates with nanofibrous microspheres and human dental pulp stem cells: A translational strategy in dental endodontics

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