Regenerative effect of basic fibroblast growth factor on periodontal healing in two‐wall intrabony defects in dogs

Abstract

The candidate bFGF treatment supported periodontal regeneration comparable with that of established benchmarks: EMD and PDGF/beta-TCP.

Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

“…At eight weeks after implantation in nonhuman primates, the FGF2-gelatin group showed significant regeneration of periodontal tissues in a dose-dependent manner [157]. Shirakata et al demonstrated that treatment with FGF2 induced the promotion of periodontal healing in two-wall intrabony defects in dogs, suggesting that they were a possible candidate for replacement of the established benchmarks enamel matrix derivative or platelet-derived growth factor combined tricalcium phosphate [110]. …”

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

“…Conventional open‐flap debridement (OFD) falls short of regenerating tissues destroyed by the disease, and current regenerative procedures offer a limited potential toward attaining a complete periodontal restoration 3 . Various biomaterials 4‐10 based on endogenous regenerative technology (ERT) have been used for periodontal tissue regeneration in addition to autogenous 11,12 and allogenic bone grafts, 13,14 but there is not a single graft material that is considered a gold standard in the treatment of intrabony defects (IBDs).…”

Effects of electrical stimulation on periodontal tissue remodeling in rats

“…Recently, tissue‐engineering procedures using growth factors have been developed to accelerate periodontal healing and regeneration . Topical application of basic fibroblast growth factor (bFGF) was shown to be a powerful pharmacological tool in periodontal healing .…”