Regeneration of the urodele limb: A review

Nye, Holly L.D.; Cameron, Jo Ann; Chernoff, Ellen A.G.; Stocum, David L.

doi:10.1002/dvdy.10236

Cited by 187 publications

(183 citation statements)

References 170 publications

(187 reference statements)

Supporting

Mentioning

180

Contrasting

Order By: Relevance

“…The proximal boundary is the fibroblast positional identity of the amputation level. The distal boundary might be conferred on initial fibroblast‐derived blastema cells by virtue of their contact with the AEC (Maden, 1977; Nye, Cameron, Chernoff, & Stocum, 2003). Confrontation of the two boundaries initiates an averaging cascade of intercalation.…”

Section: Pattern Formation In the Blastemamentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

Self Cite

109

View full text Add to dashboard Cite

This review explores the historical and current state of our knowledge about urodele limb regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of limb tissues to release resident stem cells and mononucleate cells that undergo dedifferentiation, cell cycle entry and accumulation under the apical epidermal cap. (2) The origin, phenotypic memory, and positional memory of blastema cells. (3) The role played by macrophages in the early events of regeneration. (4) The role of neural and AEC factors and interaction between blastema cells in mitosis and distalization. (5) Models of pattern formation based on the results of axial reversal experiments, experiments on the regeneration of half and double half limbs, and experiments using retinoic acid to alter positional identity of blastema cells. (6) Possible mechanisms of distalization during normal and intercalary regeneration. (7) Is pattern formation is a self‐organizing property of the blastema or dictated by chemical signals from adjacent tissues? (8) What is the future for regenerating a human limb?

show abstract

Section: Pattern Formation In the Blastemamentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

Self Cite

109

View full text Add to dashboard Cite

show abstract

“…Recognized in 1768 by Spallanzani, limb regeneration has attracted research ever since and with the advancement of molecular biology a number of the genes involved in development and regeneration of salamander limbs have been studied (see Nye et al, 2003;Gardiner and Bryant, 2007 for comprehensive reviews). A central question in the study of limb regeneration is to what extent the processes involved in the initial development of the limb and the regeneration of an extremity or parts thereof are the same and how these two processes differ.…”

Section: Regenerationmentioning

confidence: 99%

Salamander limb development: Integrating genes, morphology, and fossils

Fröbisch

Shubin

2011

Developmental Dynamics

View full text Add to dashboard Cite

The development of the tetrapod limb during skeletogenesis follows a highly conservative pattern characterized by a general proximo‐distal progression in the establishment of skeletal elements and a postaxial polarity in digit development. Salamanders represent the only exception to this pattern and display an early establishment of distal autopodial structures, specifically the basale commune, an amalgamation of distal carpal and tarsal 1 and 2, and a distinct preaxial polarity in digit development. This deviance from the conserved tetrapod pattern has resulted in a number of hypotheses to explain its developmental basis and evolutionary history. Here we summarize the current knowledge of salamander limb development under consideration of the fossil record to provide a deep time perspective of this evolutionary pathway and highlight what data will be needed in the future to gain a better understanding of salamander limb development specifically and tetrapod limb development and evolution more broadly. Developmental Dynamics 240:1087–1099, 2011. © 2011 Wiley‐Liss, Inc.

show abstract

“…Many insights into the mechanisms underlying tissue regeneration processes have been obtained from studies of limb regeneration in urodeles (for reviews, see Nye et al, 2003;Brockes and Kumar, 2008) and hemimetabolous insects (for a review, see Nakamura et al, 2008a). We have developed an experimental model system of tissue regeneration using the two-spotted cricket Gryllus bimaculatus (Mito et al, 2002;Nakamura et al, 2007Nakamura et al, , 2008aNakamura et al, ,b, 2010Mito and Noji, 2009).…”

Section: Introductionmentioning

confidence: 99%

Lowfat, a mammalian Lix1 homologue, regulates leg size and growth under the Dachsous/Fat signaling pathway during tissue regeneration†

Bando

Hamada

Kurita

et al. 2011

Developmental Dynamics

View full text Add to dashboard Cite

In the cricket Gryllus bimaculatus, missing distal parts of amputated legs are regenerated from blastemas based on positional information. The Dachsous/Fat (Ds/Ft) signaling pathway regulates blastema cell proliferation and positional information along the longitudinal axis during leg regeneration. Herein, we show that the Gryllus homologue of Lowfat (Gb'Lft), which modulates Ds/Ft signaling in Drosophila, is involved in leg regeneration. Gb'lft is expressed in regenerating legs, and RNAi against Gb'lft (Gb'lft RNAi ) suppressed blastema cell hyperproliferation caused by Gb'ft RNAi or Gb'ds RNAi but enhanced that caused by Gb'kibra RNAi or Gb'warts RNAi . In Gb'lft RNAi nymphs, missing parts of amputated legs were regenerated, but the length of the regenerated legs was shortened depending on the position of the amputation. Both normal and reversed intercalary regeneration occurred in Gb'lft RNAi nymphs, suggesting that Gb'Lft is involved in blastema cell proliferation and longitudinal leg regeneration under the Ds/Ft signaling pathway, but it is not required for intercalary regeneration.

show abstract

Regeneration of the urodele limb: A review

Cited by 187 publications

References 170 publications

Mechanisms of urodele limb regeneration

Mechanisms of urodele limb regeneration

Salamander limb development: Integrating genes, morphology, and fossils

Lowfat, a mammalian Lix1 homologue, regulates leg size and growth under the Dachsous/Fat signaling pathway during tissue regeneration†

Contact Info

Product

Resources

About