Regeneration of the liver at different periods of mononuclear infiltration induced by zymosan granules

Щербаков, В. И.; Komlyagina, T. G.; Mayanskii, D. N.

doi:10.1007/bf00799064

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“…Sharp suppression of inflammatory infiltration in mice treated with GdCI 3 can be due to reduced hemopoiesis-stimulating activity of KC [4]. At the same time, not only activated KC, but also macrophages potentiate hepatocyte regeneration [5]. The positive effect of ZG stimulation in GdCl:treated mice in our experiments probably results from repopulation of KC and potentiation of…”

Section: Resultsmentioning

confidence: 84%

Liver resistance to toxic effects of CCl4 under conditions of gadolinium chloride depression of Kupffer cells

2000

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Acute toxic hepatitis was modeled in (CBAxC57B1)F1 mice by single injection of 40% CCl(4) in oil. Pretreatment with gadolinium chloride, a selective blocker of Kupffer cells, considerably potentiated damage to hepatocytes leading to generalization of this process, delayed inflammatory infiltration, and inhibited reparative processes. Zymosan administered against the background of gadolinium chloride blockade improved liver resistance to CCl(4)-induced damage, intensified mononuclear infiltration, and accelerated reparative processes.

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Section: Resultsmentioning

confidence: 84%