Regeneration of peripheral nerves with hyperinsulin neuronopathy

Lambert, Edward H.; Mulder, Donald W.; Bastron, James A.

doi:10.1212/wnl.10.9.851

Cited by 11 publications

(7 citation statements)

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“…Electrophysiological studies were carried out in only 15 of the 34 previous cases. 3,[5][6][7][8][9][10]12,20,22 Needle examination showed evidence of denervation in all investigated patients, as occurred also in our patient. Our results agree with those of other nerve conduction studies, 9 which revealed CMAPs of reduced amplitude and normal motor CVs.…”

Section: Discussionsupporting

confidence: 80%

“…An overnight fasting test showed a plasma glucose concentration below 50 mg/dl associated with inappropriately raised insulin levels (glucose 45 mg/ dl, insulin 17.1 µU/ml). Hematological and biochemical tests including blood count; liver, thyroid, and kidney function tests; immunological tests (antinuclear antibody, anticytoplasmic antibody, rheumatoid factor); and serum vitamin B 12 and folate levels were normal. Other causes of acquired polyneuropathy such as carcinomatous polyneuropathy, paraproteinemias, uremia, diabetes mellitus, con-nective tissue diseases, amyloidosis, and hypothyroidism were excluded.…”

Section: Case Reportmentioning

confidence: 99%

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Hypoglycemic sensorimotor polyneuropathy associated with insulinoma

et al. 2000

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Hypoglycemia‐induced peripheral neuropathy due to insulinoma is unusual and, as far as we know, has previously been reported in only 34 patients. In this case report, we describe the clinical features, electrophysiological features, and pathological findings in a 37‐year‐old patient with polyneuropathy from repeated hypoglycemic episodes over a 9‐year period that related to an insulinoma. The literature is discussed. The reported case is of special interest because the peripheral neuropathy led to the correct diagnosis. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1891–1894, 2000

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Section: Discussionsupporting

confidence: 80%

Section: Case Reportmentioning

confidence: 99%

Hypoglycemic sensorimotor polyneuropathy associated with insulinoma

et al. 2000

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“…Denervation has been confirmed in several cases but few conduction studies have been reported. Lambert's patient (Lambert et al, 1960) showed no abnormality of motor nerve conduction when studied acutely. Two years later, when restudied, surface records from abductor digiti minimi revealed evidence of regeneration of nerve fibres in the ulnar nerve after peripheral damage.…”

Section: Discussionmentioning

confidence: 88%

“…As some cases have shown a glove and stocking sensory loss and loss of ankle jerks, it has been argued that the clinical picture is due to a peripheral neuropathy. Electrophysiological support for this was found in a single case studied by Lambert et al (1960). During recovery, a population of fibres in an ulnar nerve was shown to have a high threshold to electrical stimulation and slow conduction velocity.…”

mentioning

confidence: 75%

Muscle wasting after prolonged hypoglycaemic coma: case report with electrophysiological data.

Harrison¹

1976

Journal of Neurology, Neurosurgery & Psychiatry

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“…The spinal cord and peripheral nerves are spared in most cases, but in those with involvement, the pathology in the peripheral nerves has yet to be definitely identified (Blackwood and Corsellis, 1976). Lambert, Mulder and Bastron (1960) have suggested that it is due to peripheral neuropathy, while Tom and Richardson (1951) described a case where the arterior horn cells of the spinal cord were damaged. Bradley (1974) has described degeneration of the cell body of the axon within the spinal cord and dorsal root.…”

Section: Discussionmentioning

confidence: 99%