Regeneration of Meniscal Cartilage with Use of a Collagen Scaffold. Analysis of Preliminary Data*

Stone, Kevin R.; Steadman, J. Richard; Rodkey, William G.; Li, Shu-Tung

doi:10.2106/00004623-199712000-00002

Cited by 309 publications

(237 citation statements)

References 20 publications

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“…[12][13][14][15][16][17][18][19][20][21][22][23][24][25] Various types of biomaterials including fibrin, collagen, and polyglycolic acid (PGA) have been used as scaffolds for meniscal tissue engineering. Histological results of partial meniscal defects filled with bone marrow cells mixed with fibrin glue showed mature healing of the defects.…”

Section: Introductionmentioning

confidence: 99%

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

Kang

Son

Lee

et al. 2006

J Biomedical Materials Res

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Abstract:The current treatments of meniscal lesion in knee joint are not perfect to prevent adverse effects of meniscus injury. Tissue engineering of meniscus using meniscal cells and polymer scaffolds could be an alternative option to treat meniscus injury. This study reports on the regeneration of whole medial meniscus in a rabbit total meniscectomy model using the tissue engineering technique. Biodegradable scaffolds in a meniscal shape were fabricated from polyglycolic acid (PGA) fiber meshes that were mechanically reinforced by bonding PGA fibers at cross points with 75:25 poly(lactic-co-glycolic acid). The compressive modulus of the bonded PGA scaffold was 28-fold higher than that of nonbonded scaffold. Allogeneic meniscal cells were isolated from rabbit meniscus biopsy and cultured in vitro. The expanded meniscal cells were seeded onto the polymer scaffolds, cultured in vitro for 1 week, and transplanted to rabbit knee joints from which medial menisci were removed. Ten or 36 weeks after transplantation, the implants formed neomenisci with the original scaffold shape maintained approximately. Hematoxylin and eosin staining of the sections of the neomenisci at 6 and 10 weeks revealed the regeneration of fibrocartilage. Safranin-O staining showed that abundant proteoglycan was present in the neomenisci at 10 weeks. Masson's trichrome staining indicated the presence of collagen. Immunohistochemical analysis showed that the presence of type I and II collagen in neomenisci at 10 weeks was similar to that of normal meniscal tissue. Biochemical and biomechanical analyses of the tissue-engineered menisci at 36 weeks were performed to determine the quality of the tissue-engineered menisci. Tissue-engineered meniscus showed differences in collagen content and aggregate modulus in comparison with native meniscus. This study demonstrates, for the first time, the feasibility of regenerating whole meniscal cartilage in a rabbit total meniscectomy model using the tissue engineering method.

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Section: Introductionmentioning

confidence: 99%

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

Kang

Son

Lee

et al. 2006

J Biomedical Materials Res

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“…In this case problems 0022-2461 C 2006 Springer Science + Business Media, Inc. DOI: 10.1007/s10853-006-7065-y are related to availability, preservation techniques, possible transfer of diseases, individual shaping of the implant and possible immunological reactions to the implant [11]. To avoid the problems with an allograft implant, the group of Stone developed a meniscus implant based on collagen [12,13]. Probably based on the complex suturing technique and the absence of knowledge on the long-term consequences for the articular cartilage, the support for this technique is very restricted, especially in Europe.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane

Heijkants

Tienen²,

Groot³

et al. 2006

J Mater Sci

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Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane Heijkants, RGJC; Van Tienen, TG; De Groot, JH; Pennings, AJ; Buma, P; Veth, RPH; Schouten, AJ Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. In the past several types of synthetic porous materials have been made as meniscus reconstruction materials. Most of these materials lacked a good combination between suitable mechanical properties and a high interconnectivity. In this work porous scaffolds were made from the polyurethane Estane 5701-F1 by freeze drying of a dioxane and water solution in combination with salt leaching. It was possible to obtain very porous scaffolds with a very high interconnectivity. Porosity, pore size and interconnectivity can be independently adjusted by varying the amount of water, porogen size and the amount of porogen used. The obtained compression moduli of the scaffolds were between 40 kPa and 400 kPa with a variation in porosity between 72 and 87%. These scaffolds are very suitable for the use as meniscus replacement materials. C 2006 Springer Science + Business Media, Inc.

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“…Polymers such as polylactic acids (1,2) and collagens (3) have been widely studied as implantable, resorbable biomaterial matrices for a range of current or potential medical device needs. Toward this goal, recent interest in integrating the favorable biological interface attributes of biomaterials with technological functionalities such as electronics (4) or optics (5) provides a new and exciting path toward integrating devices within living tissue and eliminating the need for retrieval after their functional lifetimes are complete.…”

mentioning

confidence: 99%

Implantable, multifunctional, bioresorbable optics

Tao

Kainerstorfer

Siebert

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

113

108

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Advances in personalized medicine are symbiotic with the development of novel technologies for biomedical devices. We present an approach that combines enhanced imaging of malignancies, therapeutics, and feedback about therapeutics in a single implantable, biocompatible, and resorbable device. This confluence of form and function is accomplished by capitalizing on the unique properties of silk proteins as a mechanically robust, biocompatible, optically clear biomaterial matrix that can house, stabilize, and retain the function of therapeutic components. By developing a form of high-quality microstructured optical elements, improved imaging of malignancies and of treatment monitoring can be achieved. The results demonstrate a unique family of devices for in vitro and in vivo use that provide functional biomaterials with built-in optical signal and contrast enhancement, demonstrated here with simultaneous drug delivery and feedback about drug delivery with no adverse biological effects, all while slowly degrading to regenerate native tissue.

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Regeneration of Meniscal Cartilage with Use of a Collagen Scaffold. Analysis of Preliminary Data*

Cited by 309 publications

References 20 publications

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane

Implantable, multifunctional, bioresorbable optics

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