Regeneration of human-ear-shaped cartilage by co-culturing human microtia chondrocytes with BMSCs

Zhang, Lu; He, Aijuan; Yin, Zhen Yu; Yu, Zheyuan; Luo, Xiang; Liu, Wei; Zhang, Wenjie; Cao, Yilin; Liu, Yu; Zhou, Guangdong

doi:10.1016/j.biomaterials.2014.02.043

Cited by 106 publications

(114 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although tissue engineering has made much progress, it remains a great challenge to reconstruct functional tissue organs such as the ears, which are large in size with delicate structures [2][3][4]. The major issue is the acquirement of sufficient cartilaginous seed cells with robust chondrogenic abilities.…”

Section: Introductionmentioning

confidence: 99%

“…Bone marrow stromal cells (BMSC) and adipose-derived stromal cells (ADSC) are ideal cell source candidates to generate cartilage, as both of them possess strong proliferation and chondrogenic potentials [4,6]. ADSCs are multipotent progenitor cells with the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…However, it is unrealistic to regenerate the human-ear-shaped cartilage just using the inadequate ear chondrocytes alone. Moreover, the chondrogenic abilities of ear cells decline with age and the third generation of these chondrocytes always has lost its chondrogenic ability [4,5]. Thus, a large number of current studies are dedicated to seeking adequate cartilaginous cell sources.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chondrogenesis of Human Adipose-Derived Stem Cells by In Vivo Co-graft with Auricular Chondrocytes from Microtia

et al. 2015

View full text Add to dashboard Cite

This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266 .

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chondrogenesis of Human Adipose-Derived Stem Cells by In Vivo Co-graft with Auricular Chondrocytes from Microtia

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Several synthetic scaffolds, such as polyglycolic acid, 3,5,6,[9][10][11] polylactic acid, 12 polycaprolactone, 3,12 or copolymer combinations, have been applied with varying success. However, the degradation of these polymers has been reported to cause inflammatory reactions.…”

mentioning

confidence: 99%

Long-Term Morphological and Microarchitectural Stability of Tissue-Engineered, Patient-Specific AuriclesIn Vivo

Cohen

Hooper

Puetzer

et al. 2016

Tissue Engineering Part A

View full text Add to dashboard Cite

“…El objetivo del proceso de descelularización es eliminar de manera eficiente el material celular y nuclear, preservando los componentes y estructura del tejido nativo. De este modo, se evita la activación de la respuesta inmune y se preservan características estructurales que modulan la migración, proliferación y diferenciación celular (Zhang, 2014). La capacidad que tienen los soportes derivados de cartílago articular para inducir diferenciación condrogénica de células madre mesenquimales de tejido adiposo y de médula ósea, ha sido demostrada in vitro (Cheng et al, 2009;Estes et al, 2010) e in vivo su capacidad de formar tejido cartilaginoso (Xue et al, 2012;Yang et al, 2008).…”

Section: Productounclassified

Terapias Celulares y Productos de Ingeniería de Tejidos para el Tratamiento de Lesiones Condrales de Rodilla

Cabrera

Duque²,

Fontanilla

2017

Rev. colomb. biotecnol.

View full text Add to dashboard Cite

RESUMENEl cartílago articular es un tejido vulnerable a las lesiones de diferente etiología; siendo uno de los más afectados, el cartílago de la rodilla. Aunque la mayoría de los tratamientos convencionales reducen los síntomas, generalmente conducen a la formación de fibrocartílago; el cual, posee características diferentes a las del cartílago hialino de las articulaciones. Son pocas las aproximaciones terapéuticas que promueven el reemplazo del tejido dañado por cartílago hialino funcional; las más exitosas son las denominadas terapias avanzadas, que aplican células y productos de ingeniería de tejidos con el fin de estimular la regeneración del cartílago. La mayoría de ellas se basan en colocar soportes hechos con biomateriales de diferente origen, que sembrados o no con células exógenas o endógenas, reemplazan al cartílago dañado y promueven su regeneración. Este trabajo revisa algunas de las aproximaciones terapéuticas enfocadas en la regeneración del cartílago articular de rodilla; así como, los biomateriales más empleados en la elaboración de soportes para terapia celular e ingeniería de tejido cartilaginoso.Palabras clave: biomaterial, cartílago, lesiones de rodilla, ingeniería de tejidos. ABSTRACTThe articular cartilage is prone to suffer lesions of different etiology, being the articular cartilage lesions of the knee the most common. Although most conventional treatments reduce symptoms they lead to the production of fibrocartilage, which has different characteristics than the hyaline cartilage of the joint. There are few therapeutic approaches that promote the replacement of damaged tissue by functional hyaline cartilage. Among them are the so-called advanced therapies, which use cells and tissue engineering products to promote cartilage regeneration. Most of them are based on scaffolds made of different biomaterials, which seeded or not with endogenous or exogenous cells, can be used as cartilage artificial replacement to improve joint function. This paper reviews some therapeutic approaches focused on the regeneration of articular cartilage of the knee and the biomaterials used to develop scaffolds for cell therapy and tissue engineering of cartilage. ARTÍCULO DE REVISIÓNRev.

show abstract

Regeneration of human-ear-shaped cartilage by co-culturing human microtia chondrocytes with BMSCs

Cited by 106 publications

References 41 publications

Chondrogenesis of Human Adipose-Derived Stem Cells by In Vivo Co-graft with Auricular Chondrocytes from Microtia

Chondrogenesis of Human Adipose-Derived Stem Cells by In Vivo Co-graft with Auricular Chondrocytes from Microtia

Long-Term Morphological and Microarchitectural Stability of Tissue-Engineered, Patient-Specific AuriclesIn Vivo

Terapias Celulares y Productos de Ingeniería de Tejidos para el Tratamiento de Lesiones Condrales de Rodilla

Contact Info

Product

Resources

About