Regeneration of heterotopically transplanted autologous splenic tissue

Pabst, Reinhard; Reilmann, H.

doi:10.1007/bf00219930

Cited by 29 publications

(14 citation statements)

References 16 publications

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“…It also confirms that the lymphoid compartments of the spleen do not regenerate normally in autotransplants [23][24][25][26] or ties [27], and suggests further abnormalities in the vascular bed with the finding that the number of white pulp areas whieh have a central arteriole were greatly redueed. As with radiolabelled eolloid [25,27], the clearance from ihe blood and uptake by splenic tissue of erythrocytes with a low concentration of IgG was signiHcantly reduced in rats with regenerated splenic tissue.…”

Section: Discussionsupporting

confidence: 58%

IgG-mediated phagocytosis in regenerated splenic tissue

Clayer

Drew

Leong

et al. 1994

Clinical and Experimental Immunology

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SUMMARYThe risk of severe infections after splenectomy is well established. Operations such as autotransplantation, splenic artery ligation or partial resection have been advocated for the retention or regeneration of splenic tissue following splenic trauma. The potential of such tissue to protect from infection is unclear. The ability of splenic tissue to phagocytose IgG opsonized syngeneic erythrocytes was measured in rats 6 months following splenectomy and splenic autotransplantation, splenic artery ligation, total or partial splenectomy. and compared with eusplenic controls. In eusplenic and partially splenectomized rats 71% of the label was cleared at 3h, compared with approximately 50% in rats following total splenectomy, splenectomy and splenic autotransplantation or splenic artery ligalion. The autotransplanted and the ligated splenic tissue cleared less than 10% compared with control spleen, but there was no difference between them when clearance was expressed as uptake per gram of tissue. Splenic autoiransplants and ligated spleens were small and histologically abnormal, with an increase in the red pulp, significantly less white pulp and marginal zone, and the frequent absence of a central arteriole in the white pulp. The clearance of label was proportional to the amount of red pulp in the tissue. although the red pulp from the regenerated tissues was not as efficient at phagocytosis as control red pulp. The tissue which regenerated following autotransplantation or splenic artery ligation did not result in greater clearance of erythrocytes from the circulation than that which occurred in splenectomized rats.

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Section: Discussionsupporting

confidence: 58%

IgG-mediated phagocytosis in regenerated splenic tissue

Clayer

Drew

Leong

et al. 1994

Clinical and Experimental Immunology

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“…The splenic phagocytic index ( ± SEM), [(cpm/mg spleen)/ (cpm/mg liver)]x 100, was as follows: SL, 41.2±2.9; HS, 44.9±2.9; SS, 43.2±5.2; and TS-A, 15 Histologie examination of TS-A spleens demonstrated a relative decrease in the white pulp, scattered microcalcifi¬ cations, and increased fibrosis compared with SL spleens (Figs 2 and 3). There was a generalized increase in reticulum fibers in the autotransplanted spleen and increased collagen within the red pulp.…”

Section: Resultsmentioning

confidence: 99%

Splenic Phagocytic Function After Partial Splenectomy and Splenic Autotransplantation

Malangoni¹,

Dawes²,

Droege³

et al. 1985

Arch Surg

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“…34 The central portion may remain fibrotic or degenerative, with the periphery acting as a partially functioning spleen. 32,[35][36][37] Rat models show that splenic tissue implanted in an omental pouch has improved pneumococcal clearance compared to intraperitoneal and intramuscular implants, suggesting preserved function of splenic tissue that retains a connection with the portal circulation. 32,33 Surgical pseudosplenosis typically utilizes the mesentery as a receptive tissue bed in order to maximize the probability of success.…”

confidence: 99%