Regeneration of Blood Serum Proteins

Kerr, Wm. J.; Hurwitz, S.; Whipple, G. H.

doi:10.1152/ajplegacy.1918.47.3.356

Cited by 46 publications

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“…3. In plasmapheresis experiments sudden withdrawal of plasma protein from the animal is followed by the regeneration of a new supply even though the animal be fasting (13). With repeated plasmapheresis over a number of days the reduction in plasma protein is small in comparison with the volume of blood which must be exchanged.…”

Section: Discussionmentioning

confidence: 99%

“…5. Complete fasting is usually not attended by significant reduction in the concentration of protein in the plasma (13,16). The explanation, that fasting does lead to a loss of protein from the circulation but that concentration is maintained at the expense of reduction in blood volume, is not satisfying as it is difficult to think of an equilibrium between tissue protein and plasma protein which depends upon total quantities rather than upon concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Nutritional Edema in the Dog. V. Development of Deficits in Erythrocytes and Hemoglobin on a Diet Deficient in Protein 1

Weech¹,

Wollstein²,

Goettsch³

1937

J. Clin. Invest.

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Two years ago in a paper from this laboratory (1) some observations were presented on the development of nutritional edema in the dog. The observations were based on experiments with seven animals which developed hypoproteinemia and edema after subsisting for variable times on a diet low in protein. Since the time of that publication the experimentally induced edema has been utilized as a means of studying particular aspects of the edema problem (2) and a considerable array of additional data has been accumulated. In the light of this further experience it appears desirable to describe in more detail the events which have been observed. The present communication will deal with the behavior of the serum and tissue proteins during the experiments. MethodsAnimals.--25 dogs of mongrel breeds used in these exi~riments varied in weight from 13 to 22 kilos and averaged 17 kilos. Young adult dogs were selected by preference; their ages, not definitely known, were estimated to be between 1 and 3 years.Diet.--The first eight dogs in the series were maintained either on a synthetic diet or a natural food diet, both of which have been described previously (1). For the remaining seventeen dogs the composition of the natural food diet was modified by removing the butter fat and supplying its nutritional equivalent with lard and cod liver oil. The composition of the modified diet follows: gm, Carrots

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nutritional Edema in the Dog. V. Development of Deficits in Erythrocytes and Hemoglobin on a Diet Deficient in Protein 1

Weech¹,

Wollstein²,

Goettsch³

1937

J. Clin. Invest.

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“…Using the technique of plasmapheresis, Kerr, Hurwitz and Whipple (1,2) observed that dogs receiving food regenerate blood plasma protein more rapidly than fasting animals. Later Smith, Belt and Whipple (3) modified the experimental method by reinjecting the cell suspension simultaneously with the bleeding and reported a rapid regeneration within 15 minutes after the hemorrhage.…”

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confidence: 99%

The Influence of Diet Upon the Regeneration of Serum Protein

Melnick

Cowgill

Burack

1937

Journal of Experimental Medicine

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Page 889, 16th line from bottom, for 52.1 read 56.4; for 22.7 read 27.0. 13th line from bottom, for 43 read 52. 7th line from bottom, for 13.0 read 17.8. 6th line from bottom, for 29 read 40. Page 890, 3rd line from the top, for 12.5 read 13.3. 4th line from the top, for "This value, approximately 34 per cent of the total circulating serum protein, agrees very well with those recorded for dogs 3 and 4," read "This value is approximately 36 per cent of the total circulating serum protein. During the initial depletion week, 38.0 gm. of serum protein were removed from this animal." 20th line from top, for 30 to 40 read 35 to 55. Page 895, 2nd line in 3rd paragraph under Summary, for 30 to 40 read 35 to 55.

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“…With a decrease in the ratio the observed turbidities were less than the corresponding values determined gravimetrically. The hypoproteinemia produced experimentally by the technique of plasmapheresis has been reported to be associated with a decreased or inverted albumin to globulin ratio (13)(14)(15)(16)(17)(18)(19)(20)4). The dogs used in the present study have also shown such changes in this ratio.…”

Section: Methodsmentioning

confidence: 99%

The Influence of Prolonged, Intensive Plasmapheresis Upon the Ability of the Organism to Regenerate Serum Protein

Melnick

Cowgill

1937

Journal of Experimental Medicine

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1. When the dog is subjected to quantitative plasmapheresis and fed appropriate "synthetic" artificial rations, it is possible to evaluate the ability of the organism to regenerate serum protein from both exogenous and endogenous sources. Approximately 44 per cent of the protein, casein, fed in excess of the minimal amount needed normally to meet the general nitrogen requirements, is utilized for the formation of new serum protein. Under our experimental conditions the dog can regenerate each week solely from endogenous sources approximately 0.6 gm. of this blood protein per kilo of optimal body weight. This is equivalent to about 21 per cent of the total amount of serum protein normally present in the plasma. 2. When the dog is fed an adequate protein diet and is subjected to a régime of prolonged intensive plasmapheresis (period of 16 consecutive weeks), no impairment in the ability of the organism to regenerate serum protein from either exogenous or endogenous sources occurs. Under our conditions of experimentation the dog appears to be able to form each week an amount of the blood protein approximately equal to that normally present in the plasma. Because of this remarkable ability of the normal organism to regenerate rapidly serum protein over a relatively long period of time, it seems that loss of protein alone in conditions of Bright's disease cannot be the etiologic agent responsible for the persistence of the hypoproteinemia. An additional factor, the "specific" ability of such individuals to regenerate serum protein, must be taken into consideration.

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Regeneration of Blood Serum Proteins

Cited by 46 publications

References 0 publications

Nutritional Edema in the Dog. V. Development of Deficits in Erythrocytes and Hemoglobin on a Diet Deficient in Protein 1

Nutritional Edema in the Dog. V. Development of Deficits in Erythrocytes and Hemoglobin on a Diet Deficient in Protein 1

The Influence of Diet Upon the Regeneration of Serum Protein

The Influence of Prolonged, Intensive Plasmapheresis Upon the Ability of the Organism to Regenerate Serum Protein

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