Regeneration, Hyperplasie und Onkogenese der lymphoretikulären Organe

Unscheduled DNA-synthesis in UV-irradiated spleen lymphocytes of the rat after whole-body X-irradiation

“…Regardless of some more specific reaction pathways which are under investigation, one may conclude therefore that the X-irradiation impairment of unscheduled DNA synthesis in lymphocytes may be initially a rather nonspecific, though sensitive expression of the numerous morphological and biochemical events which precede and/or accompany cell death. With respect to later postirradiation periods, the possibility of changes within the population of splenic lymphocytes cannot be excluded (Stender, 1963;Cottier et al, 1969). The resulting cells may behave differently from normal lymphocytes as to HU-inhibited base-3H-TdR incorporation as well as to the unscheduled DNA synthesis (Fig.…”

“…1). It is suggested therefore that splenic lymphocytes taken during the period of regeneration after TBI, though morphologically similar to the cells from the normal splenic population, may differ from these with respect to their origin and/or some of their functions (Cottier et al, 1969). For example, an increase of plasma cells is observed within the period of regeneration after TBI (Stender, 1963).…”

Changes in the Thymus During the Regenerative Growth of the Liver after Partial Hepatectomy in Rats

“…According to several authors it is possible that the breakdown products of thymocyte nuclei during thymus involution are reutilized during the process of growing [4,5,19]. A thymectomy 3 days before partial hepatec tomy, or thymectomy in newborns and partial hepatectomy in the 7th week of life will slightly diminish the mitose activity but will not influence the gain of weight of the liver [20].…”