Regeneration across Metazoan Phylogeny: Lessons from Model Organisms

Li, Qiao; Yang, Hao; Zhong, Tao

doi:10.1016/j.jgg.2014.12.002

Cited by 38 publications

(38 citation statements)

References 109 publications

(133 reference statements)

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“…In other groups, such as birds, nematodes and cephalochordates, regeneration is in general exceptional or non‐existent (Li et al. ).…”

Section: Introductionmentioning

confidence: 99%

“…Notable invertebrate 'regenerators' include hydra, starfish, annelids and planarians; among vertebrates, regeneration is found in fish, and among amphibians, both in anurans and urodeles (Tanaka 2003;Brockes & Kumar 2005;Slack et al 2008). In other groups, such as birds, nematodes and cephalochordates, regeneration is in general exceptional or non-existent (Li et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Ear wound regeneration in the African spiny mouse Acomys cahirinus

et al. 2016

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While regeneration occurs in a number of taxonomic groups across the Metazoa, there are very few reports of regeneration in mammals, which generally respond to wounding with fibrotic scarring rather than regeneration. A recent report described skin shedding, skin regeneration and extensive ear punch closure in two rodent species, Acomys kempi and Acomys percivali. We examined these striking results by testing the capacity for regeneration of a third species, Acomys cahirinus, and found a remarkable capacity to repair full thickness circular punches in the ear pinna. Four-millimeter-diameter wounds closed completely in 2 months in 100% of ear punches tested. Histology showed extensive formation of elastic cartilage, adipose tissue, dermis, epidermis and abundant hair follicles in the repaired region. Furthermore, we demonstrated abundant angiogenesis and unequivocal presence of both muscle and nerve fibers in the reconstituted region; in contrast, similar wounds in C57BL/6 mice simply healed the borders of the cut by fibrotic scarring. Our results confirm the regenerative capabilities of Acomys, and suggest this model merits further attention.

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“…In other groups, such as birds, nematodes and cephalochordates, regeneration is in general exceptional or non‐existent (Li et al. ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ear wound regeneration in the African spiny mouse Acomys cahirinus

et al. 2016

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“…With tissue damage, a wound epidermis is established, followed by the formation of a blastema composed of mesenchymal progenitor cells. These cells are necessary for the proliferation and patterning of the regenerating structure leading to the next phase of regenerative outgrowth and re-patterning [15,16]. Tissue ‘repair’ is the dominant tissue injury response in mammals while regeneration is more common in some invertebrate species, such as planaria and hydra, which can regenerate complete body plans from small pieces of tissue (reviewed by Li et al [16]).…”

Section: Emerging Evidence For Mammalian Tissue Regenerationmentioning

confidence: 99%

“…These cells are necessary for the proliferation and patterning of the regenerating structure leading to the next phase of regenerative outgrowth and re-patterning [15,16]. Tissue ‘repair’ is the dominant tissue injury response in mammals while regeneration is more common in some invertebrate species, such as planaria and hydra, which can regenerate complete body plans from small pieces of tissue (reviewed by Li et al [16]). Limited regeneration has been reported in a number of adult vertebrate species including the appendages and tissues of some fish, urodeles (amphibians and newts) and larval anurans (frogs and toads) [17,18].…”

Section: Emerging Evidence For Mammalian Tissue Regenerationmentioning

confidence: 99%

Enhanced cartilage repair in ‘healer’ mice—New leads in the search for better clinical options for cartilage repair

Fitzgerald

2017

Seminars in Cell & Developmental Biology

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Adult articular cartilage has a poor capacity to undergo intrinsic repair. Current strategies for the repair of large cartilage defects are generally unsatisfactory because the restored cartilage does not have the same resistance to biomechanical loading as authentic articular cartilage and degrades over time. Recently, an exciting new research direction, focused on intrinsic cartilage regeneration rather than fibrous repair by external means, has emerged. This review explores the new findings in this rapidly moving field as they relate to the clinical goal of restoration of structurally robust, stable and non-fibrous articular cartilage following injury.

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“…On the other hand, zebrafish can regenerate fins and heart whereas newts are capable of limb and lens regeneration. Mammals have relatively very limited ability to regenerate and exhibit regeneration of injured tissues like liver, pancreas and heart [4]. In contrast, other organisms like birds, nematodes and leeches are hardly capable of any regeneration [5].…”

Section: Introductionmentioning

confidence: 99%

VEGF and FGF signaling during head regeneration in hydra

Turwankar

Ghaskadbi

2019

Preprint

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Background: Vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) signaling pathways play important roles in the formation of the blood vascular system and nervous system across animal phyla. We have earlier reported VEGF and FGF from Hydra vulgaris Ind-Pune, a cnidarian with a defined body axis, an organized nervous system and a remarkable ability of regeneration. We have now identified three more components of VEGF and FGF signaling pathways from hydra. These include FGF-1, FGF receptor 1 (FGFR-1) and VEGF receptor 2 (VEGFR-2) with a view to deciphering their possible roles in regeneration. Methods:In silico analysis of proteins was performed using Clustal omega, Swiss model, MEGA 7.0, etc. Gene expression was studied by whole mount in situ hybridization. VEGF and FGF signaling was inhibited using specific pharmacological inhibitors and their effects on head regeneration were studied. Results: Expression patterns of the genes indicate a possible interaction between FGF-1 andFGFR-1 and also VEGF and VEGFR-2. Upon treatment of decapitated hydra with pharmacological inhibitor of FGFR-1 or VEGFR-2 for 48 hours, head regeneration was delayed in treated as compared to untreated, control regenerates. When we studied the expression of head specific genes HyBra1 and HyKs1 and tentacle specific gene HyAlx in control and treated regenerates using whole mount in situ hybridization, expression of all the three genes was found to be adversely affected in treated regenerates. Conclusions:The results suggest that VEGF and FGF signaling play important roles in regeneration of hypostome and tentacles in hydra.

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Regeneration across Metazoan Phylogeny: Lessons from Model Organisms

Cited by 38 publications

References 109 publications

Ear wound regeneration in the African spiny mouse Acomys cahirinus

Ear wound regeneration in the African spiny mouse Acomys cahirinus

Enhanced cartilage repair in ‘healer’ mice—New leads in the search for better clinical options for cartilage repair

VEGF and FGF signaling during head regeneration in hydra

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