Regenerating Axons Emerge Far Proximal to the Coaptation Site in End-to-Side Nerve Coaptation without a Perineurial Window Using a T-Shaped Chamber

Akeda, Koji; Hirata, Hitoshi; Matsumoto, Mamoru; Fukuda, Aki; Tsujii, Masaya; Nagakura, Takeshi; Ogawa, S.; Yoshida, Toshimichi; Uchida, Atsushi

doi:10.1097/01.prs.0000201460.54187.d7

Cited by 37 publications

(43 citation statements)

References 26 publications

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“…Several authors have concluded that axonal damage to the donor nerve is required to induce motor collateral sprouting but may not be required to induce sensory sprouting in end-to-side neurorrhaphy [1,12,28,29]. In a recent review by Dvali et al, the authors concluded that the degree of motor axonal sprouting following end-to-side repairs depends upon the degree of axonal damage, while sensory sprouting was less dependent on the presence of injury [8].…”

Section: Discussionmentioning

confidence: 99%

Functional Recovery following an End to Side Neurorrhaphy of the Accessory Nerve to the Suprascapular Nerve: Case Report

Ray

Kasukurthi

Yee

et al. 2009

Hand (New York, N,Y.)

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The use of end-to-side neurrorhaphy remains a controversial topic in peripheral nerve surgery. The authors report the long-term functional outcome following a modified end-to-side motor reinnervation using the spinal accessory to innervate the suprascapular nerve following a C5 to C6 avulsion injury. Additionally, functional outcomes of an end-to-end neurotization of the triceps branch to the axillary nerve and double fascicular transfer of the ulnar and medial nerve to the biceps and brachialis are presented. Excellent functional recoveries are found in respect to shoulder abduction and flexion and elbow flexion.

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Section: Discussionmentioning

confidence: 99%

Functional Recovery following an End to Side Neurorrhaphy of the Accessory Nerve to the Suprascapular Nerve: Case Report

Ray

Kasukurthi

Yee

et al. 2009

Hand (New York, N,Y.)

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“…However there are some authors who still believe that the ETS with sutures could harm the donating nerve, especially small dimension nerves 8,9 .…”

Section: Many Authors Have Recently Enhanced the Results Of End-mentioning

confidence: 99%

“…According to Akeda et al 8 , the process of axonal sprouting in an intact nerve, such as ETS with fibrin glue, is slower and in smaller scale that in a nerve with violated epineurium. In an ETE, for example, the axons are identified in the repair point in about two days; in an ETS, with sutures, such event is only detected from the fifteenth day on.…”

Section: Resultsmentioning

confidence: 99%

Nerve growth factor with fibrin glue in end-to-side nerve repair in rats

Silva

Aydos

et al. 2012

Acta Cir. Bras.

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PURPOSE:To determine the effects of end-to-side nerve repair performed only with fibrin glue containing nerve growth in rats. METHODS:Seventy two Wistar rats were divided into six equal groups: group A was not submitted to nerve section; group B was submitted to nerve fibular section only. The others groups had the nerve fibular sectioned and then repaired in the lateral surface of an intact tibial nerve, with different procedures: group C: ETS with sutures; group D: ETS with sutures and NGF; group E: ETS with FG only; group F: ETS with FG containing NGF. The motor function was accompanied and the tibial muscle mass, the number and diameter of muscular fibers and regenerated axons were measured. RESULTS:All the analyzed variables did not show any differences among the four operated groups (p>0.05), which were statistically superior to group B (p<0.05), but inferior to group A (p>0.05). CONCLUSION:The end-to-side nerve repair presented the same recovery pattern, independent from the repair used, showing that the addition of nerve growth factor in fibrin glue was not enough for the results potentiating.Key words: Suture Techniques. Fibrin Tissue Adhesive. Microsurgery. Rats. RESUMO OBJETIVO:Determinar os efeitos do reparo nervoso término-lateral realizado apenas com cola de fibrina contendo fator de crescimento nervoso em ratos. MÉTODOS:Setenta e dois ratos Wistar foram distribuídos em seis grupos: A -não submetido à secção nervosa; B -secção do nervo fibular (sem reparo); Os outros grupos tiveram o nervo fibular seccionado e então reparado na superfície lateral do nervo tibial

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“…However, to date there is no consensus on the realization of reanimation of the facial paralysis in one or two surgical stages 2,4,9 . In this context, the main objective of this experimental research was to compare aspects of muscle reinnervation with nerve graft in one and two surgical stages, using the end-to-side neurorrhaphy, because this technique of neurorrhaphy has the great advantage of not injuring the epineurium of donor nerve [17][18][19][20][21][22] and, consequently, any nerve could potentially be used as a donor 22 . A comprehensive review of pertinent English literature (Medline and Embase databases)…”

Section: Discussionmentioning

confidence: 99%

“…The end-to-side neurorrhaphy without donor nerve lesion, introduced in 1992 by Viterbo et al 17 , has been increasingly used [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] and has the advantage of not injuring the donor nerve.…”

Section: Introductionmentioning

confidence: 99%

Muscle reinnervation in one or two stages?: experimental study in rats with end-to-side nerve graft

et al. 2012

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PURPOSE: To compare muscle reinnervation in one and two surgical stages using end-to-side neurorrhaphy (ESN) without donor nerve injury. METHODS: The experiment was performed on four groups of 20 rats. Group 1 (G1), one stage, received the graft which was sutured to the tibial nerve, with ESN, and its free stump was sutured end-to-end to the distal stump of the sectioned peroneal nerve (PN), all in the same operation. In Group 2 (G2), two stages, the nerve graft was sutured to the tibial nerve, with ESN. Two months later the PN was sectioned and its distal stump connected to the distal stump of the graft as in G1. Normal control group (Gn) received the graft only sutured to the tibial nerve, with ESN. Denervated control group (Gd), as well received the graft and had the PN sectioned and its two stumps buried in adjacent musculature, with the aim of denervating the cranial tibial muscle (CTM), the target of this study. The parameters used to evaluate CTM reinnervation were muscle mass, muscle fiber's minimum diameter and area. RESULTS: The mean CTM mass, the average of the muscular fibers areas and the average of the muscular fiber minimum diameters was higher (all p<0.0001) in G2 than in G1. Comparing the four groups, these parameters had their maximum expression in Gn and the minimum in Gd, as expected. CONCLUSION: The two stages showed better muscle reinnervation than one stage.

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Regenerating Axons Emerge Far Proximal to the Coaptation Site in End-to-Side Nerve Coaptation without a Perineurial Window Using a T-Shaped Chamber

Abstract: The authors could not locate the site of axonal sprouting in end-to-side neurorrhaphy without a perineurial window; however, this study cast doubts on current hypothesis on the mode of axonal regeneration in end-to-side neurorrhaphy.

Cited by 37 publications

References 26 publications

Functional Recovery following an End to Side Neurorrhaphy of the Accessory Nerve to the Suprascapular Nerve: Case Report

Functional Recovery following an End to Side Neurorrhaphy of the Accessory Nerve to the Suprascapular Nerve: Case Report

Nerve growth factor with fibrin glue in end-to-side nerve repair in rats

Muscle reinnervation in one or two stages?: experimental study in rats with end-to-side nerve graft

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