Regarding the Article “Thrombocytosis As a Predictor of Distant Recurrence in Patients with Rectal Cancer”

Castillo-Pérez, José Juan

doi:10.1016/j.arcmed.2012.11.005

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Platelet count has been reported to have predictive value in various cancers including CRC, and increased platelet levels have been postulated as one of the mechanisms of hematogenous spread of metastases. [15] One study reported that pretreatment platelet counts were correlated with right-sided colon cancers, venous invasion, and tumor size, and also it strongly correlated with the response rate. Furthermore, patients with pretreatment thrombocytosis had significantly shorter local recurrence-free survival.…”

Section: Discussionmentioning

confidence: 99%

Correlation of pretreatment hemoglobin and platelet counts with clinicopathological features in colorectal cancer in Saudi population

Alsaeed

Tunio

Al-Obaid

et al. 2014

Saudi J Gastroenterol

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Background/Aims:In Saudi Arabia, colorectal cancers (CRCs) are registered as the second most common cancers. However, no data has been reported about correlation of the severity of the anemia and pretreatment platelets level with clinicopathological features of CRCs. We aimed to evaluate the association between pretreatment hemoglobin and platelets level and the clinicopathological features of CRC patients in Saudi Arabia.Materials and Methods:Between September 2005 and November 2011, One hundred and fifty-four confirmed CRC patients underwent thorough physical examination, blood investigations, endoscopic ultrasonography (EUS), and computed tomography (CT) for staging before surgery. Findings of physical assessment, EUS, CT, and pathological specimens were correlated with pretreatment hemoglobin and platelets levels the Pearson-Kendall tau correlative coefficients.Results:The mean age of cohort was 56.6 years (range: 26-89). Left-sided CRC were predominant (97 patients; 63%). Mean size of primary tumor was 6 cms (1-18) SD ± 3.55. Mean values of hemoglobin, red blood cells, hematocrit, white blood cells, and platelets were 11.9 SD ± 2.3, 35.5 SD ± 5.7, 4.43 × 106/mL SD ± 0.6, 7.67 106/mL SD ± 2.44, and 343 × 103/mL SD ± 164.4, respectively. Pretreatment hemoglobin was inversely correlated with primary tumor size (R: 0.71, R2: 1.55, P = 0.0001) and nodal status (R: 0.02, R2: 0.05, P = 0.01). Right-sided CRC had significantly low pretreatment hemoglobin levels (P = 0.001). Interestingly, pretreatment thrombocytosis was seen only in right-sided CRC (P = 0.0001).Conclusion:Pretreatment anemia and thrombocytosis were found mainly in right-sided CRCs and advanced primary and nodal stages. Pretreatment hemoglobin and thrombocytosis can be considered as useful prognostic markers in CRC patients.

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Section: Discussionmentioning

confidence: 99%

Correlation of pretreatment hemoglobin and platelet counts with clinicopathological features in colorectal cancer in Saudi population

Alsaeed

Tunio

Al-Obaid

et al. 2014

Saudi J Gastroenterol

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Extricating the Association Between the Prognostic Factors of Colorectal Cancer

Younis

Balasubramanian

Meyyazhagan

et al. 2020

J Gastrointest Canc

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The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis

Zhang

et al. 2017

Oncotarget

140

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Recently, several studies have reported that inflammatory response and elevated platelet counts may be associated with the poor prognosis of colorectal cancer. This meta-analysis was designed to analyze and evaluate the prognostic role of elevated preoperative or pretreatment neutrophils-to-lymphocytes ratio, platelet-to-lymphocytes ratio or platelet counts in patients with colorectal cancer. We searched PubMed, EMBASE, Cochrane Library and Web of Science to April, 2016. A total of 23 studies (N = 11762 participants) were included for this meta-analysis. Elevated neutrophils-to-lymphocytes ratio have a close relationship with the poor Overall Survival of colorectal cancer with the pooled HR being 1.92 [95% CI 1.57–2.34; P < 0.00001]. This meta-analysis indicated that elevated neutrophils-to-lymphocytes ratio, platelet-to-lymphocytes ratio or platelet counts may be a cost-effective and noninvasive serum biomarker for poor prognosis for patients with colorectal cancer.

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Regarding the Article “Thrombocytosis As a Predictor of Distant Recurrence in Patients with Rectal Cancer”

Cited by 3 publications

References 3 publications

Correlation of pretreatment hemoglobin and platelet counts with clinicopathological features in colorectal cancer in Saudi population

Correlation of pretreatment hemoglobin and platelet counts with clinicopathological features in colorectal cancer in Saudi population

Extricating the Association Between the Prognostic Factors of Colorectal Cancer

The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis

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