Regarding “Neutrophil-lymphocyte ratio as a predictor of cognitive dysfunction in carotid endarterectomy patients”

Kayadibi, Hüseyin; Uyanık, Metin; Sertoğlu, Erdim

doi:10.1016/j.jvs.2014.03.276

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Indeed, it has been shown that surgery-induced release of several cytokines disrupts the BBB, leading to enhanced macrophage migration into the hippocampus, subsequent neuro-inflammation and POCD symptoms (Terrando et al, 2011 ). Of note, one study found that patients with an increased ratio of neutrophils to lymphocytes had a three-times higher probability to experience cognitive dysfunction after carotinoid surgery (Kayadibi et al, 2014 ). Moreover, intraoperative transfusion of ECs (>3 units) has been described as an independent risk factor for development of POCD (Zhu S.-H. et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

The “Aging Factor” Eotaxin-1 (CCL11) Is Detectable in Transfusion Blood Products and Increases with the Donor’s Age

Hoefer

Luger

Dal-Pont

et al. 2017

Front. Aging Neurosci.

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Background: High blood levels of the chemokine eotaxin-1 (CCL11) have recently been associated with aging and dementia, as well as impaired memory and learning in humans. Importantly, eotaxin-1 was shown to pass the blood-brain-barrier (BBB) and has been identified as crucial mediator of decreased neurogenesis and cognitive impairment in young mice after being surgically connected to the vessel system of old animals in a parabiosis model. It thus has to be assumed that differences in eotaxin-1 levels between blood donors and recipients might influence cognitive functions also in humans. However, it is unknown if eotaxin-1 is stable during processing and storage of transfusion blood components. This study assesses eotaxin-1 concentrations in fresh-frozen plasma (FFP), erythrocyte concentrate (EC), and platelet concentrate (PC) in dependence of storage time as well as the donor’s age and gender.Methods: Eotaxin-1 was measured in FFP (n = 168), EC (n = 160) and PC (n = 8) ready-to-use for transfusion employing a Q-Plex immunoassay for eotaxin-1. Absolute quantification of eotaxin-1 was performed with Q-view software.Results: Eotaxin-1 was consistently detected at a physiological level in FFP and EC but not PC. Eotaxin-1 levels were comparable in male and female donors but increased significantly with rising age of donors in both, FFP and EC. Furthermore, eotaxin-1 was not influenced by storage time of either blood component. Finally, eotaxin-1 is subject to only minor fluctuations within one donor over a longer period of time.Conclusion: Eotaxin-1 is detectable and stable in FFP and EC and increases with donor’s age. Considering the presumed involvement in aging and cognitive malfunction, differences in donor- and recipient eotaxin-1 levels might affect mental factors after blood transfusion.

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Section: Discussionmentioning

confidence: 99%

The “Aging Factor” Eotaxin-1 (CCL11) Is Detectable in Transfusion Blood Products and Increases with the Donor’s Age

Hoefer

Luger

Dal-Pont

et al. 2017

Front. Aging Neurosci.

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“…Second, NLR integrates the detrimental effects of neutrophilia (an indicator of inflammation) and lymphopenia (an indicator of physiological stress) and has emerged as a useful prognostic marker in many studies, which claim inflammation as the main cause of pathology ( Kayadibi et al , 2014 ). To assess the value of the NLR in this patient group, it is important to determine whether the increase in NLR is a result of a low count of lymphocytes or a high neutrophil count.…”

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confidence: 99%

Value of neutrophil to lymphocyte ratio as a biomarker in colorectal adenocarcinoma

Sertoğlu

Uyanık

Kayadibi

2016

European Journal of Cancer Prevention

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“…The systemic immune-inflammation index (SII), a relatively novel inflammatory index that combines peripheral lymphocyte, neutrophil, and platelet counts, can be obtained without any additional financial burden. A growing body of studies has shown the potential prognostic value of POD for head and neck free-flap reconstruction, abdominal surgery, esophagectomy, carotid endarterectomy and cardiac surgery [14][15][16][17][18]. However, few studies have shown that the SII can be used to predict postoperative delirium (POD) in older hip fracture patients, particularly those with intertrochanteric fractures.…”

Section: Introductionmentioning

confidence: 99%

Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients

Yan,

Huang,

Chen

et al. 2024

J Orthop Surg Res

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Background and purpose The systemic immune-inflammation index (SII), a novel inflammation index derived from the counts of circulating platelets, neutrophils and lymphocytes, has been studied in the treatment of acute cancer and ischemic stroke (AIS). However, the clinical value of the SII in postoperative delirium patients has not been further investigated. The purpose of our research was to study the incidence and preoperative risk factors for postoperative delirium (POD) and verify whether the SII could serve as a potential marker for POD in older intertrochanteric fracture patients. Finally, we created a novel nomogram for predicting POD in older patients with intertrochanteric fractures. Methods We enrolled elderly patients with intertrochanteric fractures who underwent proximal femoral nail antirotation (PFNA) between February 2021 and April 2023. Univariate and multivariate logistic analyses were subsequently performed to confirm the risk factors and construct a nomogram model.Calibration curve and clinical decision curve analysis (DCA) were used to assess the model’s fitting performance. The performance of the nomogram was evaluated for discrimination, calibration, and clinical utility. Results A total of 293 patients were eligible for inclusion in the study, 25.6% (75/293) of whom had POD. The POD patients had higher SII values than the non-POD patients. The SII was strongly correlated with POD in older intertrochanteric fracture patients, and the optimal cutoff value was 752.6 × 109. Multivariate analysis revealed that age, diabetes, total albumin, SII > 752.6 × 109 and a CRP > 20.25 mg/L were independent risk factors for POD patients. By incorporating these 5 factors, the model achieved a concordance index of 0.745 (95% CI, 0.683–0.808) and had a well-fitted calibration curve and good clinical application value. Conclusion The SII is a simple and valuable biomarker for POD, and the new nomogram model can be used to accurately predict the occurrence of POD. They can be utilized in clinical practice to identify those at high risk of POD in older intertrochanteric fracture patients.

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Regarding “Neutrophil-lymphocyte ratio as a predictor of cognitive dysfunction in carotid endarterectomy patients”

Cited by 5 publications

References 6 publications

The “Aging Factor” Eotaxin-1 (CCL11) Is Detectable in Transfusion Blood Products and Increases with the Donor’s Age

The “Aging Factor” Eotaxin-1 (CCL11) Is Detectable in Transfusion Blood Products and Increases with the Donor’s Age

Value of neutrophil to lymphocyte ratio as a biomarker in colorectal adenocarcinoma

Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients

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