2014
DOI: 10.1016/j.jvs.2014.03.276
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Regarding “Neutrophil-lymphocyte ratio as a predictor of cognitive dysfunction in carotid endarterectomy patients”

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Cited by 5 publications
(5 citation statements)
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“…Indeed, it has been shown that surgery-induced release of several cytokines disrupts the BBB, leading to enhanced macrophage migration into the hippocampus, subsequent neuro-inflammation and POCD symptoms (Terrando et al, 2011 ). Of note, one study found that patients with an increased ratio of neutrophils to lymphocytes had a three-times higher probability to experience cognitive dysfunction after carotinoid surgery (Kayadibi et al, 2014 ). Moreover, intraoperative transfusion of ECs (>3 units) has been described as an independent risk factor for development of POCD (Zhu S.-H. et al, 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, it has been shown that surgery-induced release of several cytokines disrupts the BBB, leading to enhanced macrophage migration into the hippocampus, subsequent neuro-inflammation and POCD symptoms (Terrando et al, 2011 ). Of note, one study found that patients with an increased ratio of neutrophils to lymphocytes had a three-times higher probability to experience cognitive dysfunction after carotinoid surgery (Kayadibi et al, 2014 ). Moreover, intraoperative transfusion of ECs (>3 units) has been described as an independent risk factor for development of POCD (Zhu S.-H. et al, 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…Second, NLR integrates the detrimental effects of neutrophilia (an indicator of inflammation) and lymphopenia (an indicator of physiological stress) and has emerged as a useful prognostic marker in many studies, which claim inflammation as the main cause of pathology ( Kayadibi et al , 2014 ). To assess the value of the NLR in this patient group, it is important to determine whether the increase in NLR is a result of a low count of lymphocytes or a high neutrophil count.…”
mentioning
confidence: 99%
“…The systemic immune-inflammation index (SII), a relatively novel inflammatory index that combines peripheral lymphocyte, neutrophil, and platelet counts, can be obtained without any additional financial burden. A growing body of studies has shown the potential prognostic value of POD for head and neck free-flap reconstruction, abdominal surgery, esophagectomy, carotid endarterectomy and cardiac surgery [14][15][16][17][18]. However, few studies have shown that the SII can be used to predict postoperative delirium (POD) in older hip fracture patients, particularly those with intertrochanteric fractures.…”
Section: Introductionmentioning
confidence: 99%