Refractory oral ulcers in eosinophilic granulomatosis with polyangiitis

OTSUKA, Takuya; Iwata, Hiroaki; Kosumi, Hideyuki; Muramatsu, Ken; Ito, Takamasa; Tsujiwaki, Masumi; Fujita, Yasuyuki; Kamaguchi, Mayumi; Kitagawa, Yoshimasa; Shimizu, Hiroshi

doi:10.1111/1346-8138.14897

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Blister lesions are observed as cutaneous lesions in 10.2% of EGPA patients [2]. Concerning oral lesions in EGPA, only ulcers have been previously reported [3][4][5]. Our patient had blisters on the tongue, which are uncommon in EGPA as both oral and cutaneous manifestations.…”

Section: Discussionmentioning

confidence: 49%

A case of eosinophilic granulomatosis with polyangiitis presented with blisters on the tongue

2022

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Section: Discussionmentioning

confidence: 49%

A case of eosinophilic granulomatosis with polyangiitis presented with blisters on the tongue

2022

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“…Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a rare condition, immune-mediated, and multisystemic disease characterised by BE and TE, late-onset asthma, and small-to-medium vessel vasculitis [61]. Oral lesions represent an uncommon presentation; however, ulcers involve the palate, tongue, and floor of the mouth [62,63]. Gingival bleeding and painful blisters on the tongue have been reported by some research groups.…”

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confidence: 99%

Eosinophils in Oral Disease: A Narrative Review

Al-Azzawi,

Paolini,

Cirillo

et al. 2024

IJMS

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The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body’s defence against bacterial, viral, and parasitic infections, but they are also implicated in haemostatic processes, including immunoregulation and allergic reactions. They contain cytoplasmic granules which can be selectively mobilised and secrete specific proteins, including chemokines, cytokines, enzymes, extracellular matrix, and growth factors. There are multiple biological and emerging functions of these specialised immune cells, including cancer surveillance, tissue remodelling and development. Several oral diseases, including oral cancer, are associated with either tissue or blood eosinophilia; however, their exact mechanism of action in the pathogenesis of these diseases remains unclear. This review presents a comprehensive synopsis of the most recent literature for both clinicians and scientists in relation to eosinophils and oral diseases and reveals a significant knowledge gap in this area of research.

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