Refractive outcome of prethreshold retinopathy of prematurity treated by diode laser: follow-up at 5&amp;nbsp;years

Nguyen, Phuoc Huu; Catt, Caroline; Nguyen, Tinh Xuan; Pham, Van Trọng

doi:10.2147/opth.s84077

Cited by 17 publications

(20 citation statements)

References 19 publications

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“…High prevalence of refractive errors, mainly myopia and high myopia are main functional disturbances not only in threshold [15], [18] but in prethreshold ROP laser treated infants [5], [6], [19], [20]. In our study the mean spherical equivalent for the whole group was -1.82 D, which is similar to the results of Kuo et al, (-1.71) [21], Lolas et al, (-1.75 D) [22] and Nguyen et al, (-2.87 D) [12]. Higher SE values than ours were reported in many other studies.…”

Section: Discussionsupporting

confidence: 88%

“…These results are similar to the squint rate of ETROP study [16] and lower than data reported by Stoica et al, (46.15%) and Sahni et al, (50%) [7], [17]. Very low strabismus rate was found by Katoch et al, (8.3%) and Nguyen et al, (10%) [12], [13]. These big differences between different studies can be mainly explained with the different follow-up time, but all show that esotropia is the main type of strabismus.…”

Section: Discussionsupporting

confidence: 86%

“…In our study, ROP treated children were with a mean birth weight of 928.9 g (SD ± 252.8g) and meant gestational age of 27.3 weeks (SD ± 1.78w). They are higher than those reported by studies where ROP screening guidelines were BW < 1250 g [5], [9] and lower than these discussed by many other authors with higher screening criteria [7], [11], [12], [13], [14].…”

Section: Discussionmentioning

confidence: 55%

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Refractive Status in Children with Laser-Treated Retinopathy of Prematurity: Our Experience in Bulgaria

Veleva¹,

Chernodrinska²

2019

Open Access Maced J Med Sci

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BACKGROUND: With the establishment of laser photocoagulation as a standard treatment modality for prethreshold retinopathy of prematurity (ROP), a dramatic reduction of cases with ROP blindness and severe visual impairment have been reported. In the same time, high refractive errors, a common complication in ROP cases and especially in ROP treated infants, have become the main cause of visual and often severe visual impairment. AIM: The purpose of our study was to analyse the long-term refractive status in children at 3.5 years after laser-treatment for type 1 prethreshold ROP. PATIENTS AND METHODS: A retrospective, one centre study of refractive status of 18 children with laser-treated type 1 prethreshold ROP was conducted. The refraction after cycloplegia with 1% cyclopentolate was measured at a mean age of 3.56 years (SD ± 0.34). Hyperopia was subdivided into two groups – low hyperopia (SE < +5.0 D) and high hyperopia (SE ≥ +5.0 D). Myopia was classified as myopia (SE ≥ –0.25D) and high myopia (SE ≥ -5.0 D). Astigmatism was divided into low astigmatism (plus CD ≥ +1.0 D) and high astigmatism (plus CD ≥ +2.0 D). RESULTS: Thirty-three eyes of 18 children were recruited in the study. Three eyes were excluded because of unfavourable anatomical results. The mean gestational age at birth was 27.3 weeks (24-31 weeks, SD ± 1.78), and the mean birth weight – 928.9 g (550-1500 g, SD ± 252.8). The mean spherical equivalent for the whole group was -1.82 D and ranged from -9.00 D to +4.50 D (SD ± 3.48). Hyperopia was observed in 12 (36.4%) eyes. Myopic refraction had 21 (63.6%) eyes. Astigmatism was detected in 18 (54.5%) eyes. Anisometropia had 3 (16.7%) children. Six children (33.4%) had strabismus (4 esotropia; 2 exotropia). CONCLUSION: High per cent of treated infants for vision-threatening ROP have visual significant refractive errors and strabismus that can cause serious visual impairment if not treated properly and on time.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 55%

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Refractive Status in Children with Laser-Treated Retinopathy of Prematurity: Our Experience in Bulgaria

Veleva¹,

Chernodrinska²

2019

Open Access Maced J Med Sci

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“…The study depicted the long-term outcome in children treated for ROP with laser therapy. Comparison among the studies[11121314151617] about the patient characteristics are tabulated in Table 4. All the studies including the present study had much higher mean birth weight and mean gestational age compared to ETROP cohort [(703 g) and (25 weeks)].…”

Section: Discussionmentioning

confidence: 99%

Refractive, sensory, and biometric outcome among retinopathy of prematurity children with a history of laser therapy: A retrospective review from a tertiary care center in South India

Anilkumar

Anandi

Shah

et al. 2019

Indian J Ophthalmol

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Purpose: Ocular morbidities like high refractive error, strabismus, and amblyopia are common among laser-treated retinopathy of prematurity children (ROP). Long-term optical status and refractive outcomes including the sensory outcomes were less investigated in these children from this region. The purpose of our study is to evaluate the long-term outcome (refractive, biometric profile, sensory) of treatment for ROP using laser. Methods: This study is a retrospective, cross-sectional, observational, and intervention research among 6–15-year-old children who underwent laser for ROP with a minimum of 6-year follow-up. Results: Eighty lasered eyes of 41 children were assessed. Mean age was 9.71 years (±3.39). Seventy-three eyes (91.2%) achieved visual acuity better than 20/40. The mean visual acuity in LogMAR was 0.18 (20/30). The mean spherical equivalence was −5.29 D ± 4.9. Mean astigmatism measured was −1.53 DC (range: +0.50 DC to −4.5DC). Fifty-three eyes (66.25%) had significant astigmatism. The mean axial length was 23.5 ± 1.35 (21–26) mm. Mean lens thickness was 3.76 ± 0.30 (3.03–4.34) mm. Correlation analysis among the low and high spherical equivalent group signified that axial length ( P value = 0.001), visual acuity ( P value = 0.0002), and myopic shift ( P value = 0.0006) were found to be statistically significant. Stereopsis better than 480 s of arc for near was observed in 41% children. Structural posterior pole sequelae developed in 3 eyes (3.75%). Conclusion: A significant number of children with high myopia, astigmatism, and strabismus had satisfactory visual outcome observed at long-term follow-up after treatment for ROP using laser. Our study revealed that myopia was influenced by an increase in axial length than the lens thickness.

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“…Specifically for high myopia, laser has been regarded as a risk factor, while anti-VEGF has been regarded as a protective factor [ 11 , 15 ]. Many specialists highlighted the need of long-term follow-up, especially in laser-treated patients [ 34 , 35 ]. However, Kuo et al [ 30 ] found no significant difference in the myopic status of eyes that were treated with either anti-VEGF (27 eyes) or laser (26 eyes).…”

Section: Discussionmentioning

confidence: 99%

Comparison of efficacy between anti-vascular endothelial growth factor (VEGF) and laser treatment in Type-1 and threshold retinopathy of prematurity (ROP)

Zhang

Liao

et al. 2018

BMC Ophthalmol

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BackgroundRetinopathy of Prematurity (ROP) is one of the most common causes of childhood blindness worldwide. Comparisons of anti-VEGF and laser treatments in ROP are relatively lacking, and the data are scattered and limited. The objective of this meta-analysis is to compare the efficacy of both treatments in type-1 and threshold ROP.MethodsA comprehensive literature search on ROP treatment was conducted using PubMed and Embase up to March 2017 in all languages. Major evaluation indexes were extracted from the included studies by two authors. The fixed-effects and random-effects models were used to measure the pooled estimates. The test of heterogeneity was performed using the Q statistic.ResultsTen studies were included in this meta-analysis. Retreatment incidence was significantly increased for anti-VEGF (OR 2.52; 95% CI 1.37 to 4.66; P = 0.003) compared to the laser treatment, while the incidences of eye complications (OR 0.29; 95% CI 0.10 to 0.82; P = 0.02) and myopia were significantly decreased with anti-VEGF compared to the laser treatment. However, there was no difference in the recurrence incidence (OR 1.86; 95% CI 0.37 to 9.40; P = 0.45) and time between treatment and retreatment (WMD 7.54 weeks; 95% CI 2.00 to 17.08; P = 0.12).ConclusionThis meta-analysis indicates that laser treatment may be more efficacious than anti-VEGF treatment. However, the results of this meta-analysis also suggest that laser treatment may cause more eye complications and increase myopia. Large-scale prospective RCTs should be performed to assess the efficacy and safety of anti-VEGF versus laser treatment in the future.Electronic supplementary materialThe online version of this article (10.1186/s12886-018-0685-6) contains supplementary material, which is available to authorized users.

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Refractive outcome of prethreshold retinopathy of prematurity treated by diode laser: follow-up at 5 years

Cited by 17 publications

References 19 publications

Refractive Status in Children with Laser-Treated Retinopathy of Prematurity: Our Experience in Bulgaria

Refractive Status in Children with Laser-Treated Retinopathy of Prematurity: Our Experience in Bulgaria

Refractive, sensory, and biometric outcome among retinopathy of prematurity children with a history of laser therapy: A retrospective review from a tertiary care center in South India

Comparison of efficacy between anti-vascular endothelial growth factor (VEGF) and laser treatment in Type-1 and threshold retinopathy of prematurity (ROP)

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