Refractive evaluation in children with growth defect

Parentin, Fulvio; Tonini, G.; Perissutti, Paolo

doi:10.1076/ceyr.28.1.11.23491

Cited by 28 publications

(25 citation statements)

References 11 publications

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“…Accordingly, optic nerve hypoplasia and pseudopapilledema, as well as reduced retinal vascularization, are all described as possible signs of GH deficiency. 8 However, our patients did not have a congenital anomaly of the eye and, on detailed ophthalmologic examination, showed only a tendency to hyperopia due to the small diameter of the globe.…”

Section: Discussionmentioning

confidence: 53%

“…After 6 years of age, refraction is modified mainly by increases in axial length. 8 In an earlier clinical study of 12 untreated patients with LS, refraction examination yielded only a tendency toward hyperopia related to the small globe axis, thick lens, and steep corneal curvature. 4 These differences from normal values in the literature reflect the influence of IGF-1 on the various components of the eye.…”

Section: Discussionmentioning

confidence: 94%

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The Globe and Orbit in Laron Syndrome

Kornreich¹,

Konen²,

Lilos³

et al. 2011

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 94%

The Globe and Orbit in Laron Syndrome

Kornreich¹,

Konen²,

Lilos³

et al. 2011

AJNR Am J Neuroradiol

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“…The latter feature could be related to growth hormone deficiency, 21,22 which is proposed as the cause of the various underdevelopment features of FA. The short AL and progressive increase in lens thickness appear to have predisposed the first sibling to the development of pupillary block, but it was not clear what induced the precipitous rise in IOP.…”

Section: Discussionmentioning

confidence: 99%

Increased crystalline lens thickness and phacomorphic glaucoma in patients with Fanconi anemia

Elgohary¹,

Ks²,

Siriwardena³

et al. 2006

Journal of Cataract and Refractive Surgery

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“…Direct support for a causal association comes from studies of individuals who fail to produce insulin-like growth factor 1 (IGF-1) due to growth hormone (GH) deficiency. Children with GH deficiency have shorter than usual axial lengths as well as short stature 22 . Furthermore, GH supplementation in these patients, and IGF-1 supplementation in patients with Laron syndrome (dysfunction of the GH receptor), at least partially brings axial length back within the normal range, as also occurs for height 23,24 .…”

Section: Introductionmentioning

confidence: 99%

Body Stature Growth Trajectories during Childhood and the Development of Myopia

et al. 2013

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Purpose-Stature at a particular age can be considered the cumulative result of growth during a number of preceding growth trajectory periods. We investigated whether height and weight growth trajectories from birth to age 10 years were related to refractive error at ages 11 and 15 years, and eye size at age 15 years. Design-Prospective analysis in a birth cohort.Participants-Children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) United Kingdom birth cohort (minimum N=2,676).Methods-Growth trajectories between birth and 10 years were modeled from a series of height and weight measurements (N=6,815). Refractive error was assessed by non-cycloplegic autorefraction at ages 11 and 15 years (minimum N=4,737). Axial length and radius of corneal curvature were measured with an IOLmaster at age 15 years (minimum N=2,676). Growth trajectories, and an allelic score for 180 genetic variants associated with adult height, were tested for association with refractive error and eye size.Main outcome measures-Non-cycloplegic autorefraction at ages 11 and 15 years, and axial length and corneal curvature at age 15 years.Results-Height growth trajectory during the linear phase between 2.5-10 years was negatively associated with refractive error at 11 and 15 years (P<0.001), but explained <0.5% of inter-subject variation. Height and weight growth trajectories, especially shortly after birth, were positively associated with axial length and corneal curvature (P<0.001), predicting 1-5% of trait variation. Height growth after 2.5 years was not associated with corneal curvature, whilst the association with axial length continued up to 10 years. The height allelic score was associated with corneal curvature (P=0.03) but not with refractive error or axial length.Address for correspondence and requests for reprints: Dr Kate Northstone, Department of Social Medicine, Oakfield House, Oakfield Grove, Clifton, Bristol, BS8 1TQ, UK, Tel: +44 (0) Conclusions-Up to the age of 10 years, shared growth mechanisms contribute to scaling of eye and body size but minimally to the development of myopia.

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Refractive evaluation in children with growth defect

Abstract: Our findings emphasise the possible role of growth hormone in ocular development, and its interaction with the physiological process of emmetropization.

Cited by 28 publications

References 11 publications

The Globe and Orbit in Laron Syndrome

The Globe and Orbit in Laron Syndrome

Increased crystalline lens thickness and phacomorphic glaucoma in patients with Fanconi anemia

Body Stature Growth Trajectories during Childhood and the Development of Myopia

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