Reflex resistance to anesthesia in partially denervated neurons

Anatomical and Physiological Correlates of Plasticity in the Central Nervous System

“…They concluded that sprouting of afferent terminals is a more po tent factor than sensitization of partially denervated neurons. The same conclusion was reached by M c C ouch et al [27] on finding that internuncial potentials increased only to the degree of increase in afferent terminal potential [7,26] in hyperreflexia ( fig. 14).…”

“…On the other hand, D 'Aquili et al [7] tested the influence of sodium pentobarbital on monkeys with chronic unilateral lesions of which ten had hemisection of the cord, three had section of one pyramid, and three had unilateral cortical lesions. One monkey with a lesion of area 4 was examined before and after transection of the cord.…”

Projections from the mesopontine tegmental anesthesia area to regions involved in pain modulation

“…For example, spinal cord injury suppresses the ability of systemic barbiturates and ketamine to abolish both spinal nocifensive reflexes and nociceptive responses of dorsal horn neurons below the level of the injury (D'Aquili et al, 1966;Tomemori et al, 1981). Likewise, pain modulation by halothane, cyclopropane, isoflurane and nitrous oxide is affected by lesions or blockade of synaptic transmission at specific supraspinal sites (Roizen et al, 1978;Zhang et al, 1999;Kingery et al, 2002;Stabernack et al, 2005).…”