Development of an Animal Model for the Study of Spinal Spasticity

Taylor, Julian; VierckJr., Charles J.; Munson, John B.

doi:10.1007/978-3-642-78367-8_20

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Consistent with this approach, withdrawal reflexes are utilized commonly as measures of nociceptive sensitivity in laboratory animals (Hammond 1989). However, reflex activation in the cat is resistant to suppression by ketamine (Taylor et al. 1993), including withdrawal responses (Glen 1973; Wright 1982).…”

Section: Introductionmentioning

confidence: 99%

Effects of ketamine on electroencephalographic and autonomic arousal and segmental reflex responses in the cat

Taylor

Vierck

2003

Veterinary Anaesthesia and Analgesia

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Section: Introductionmentioning

confidence: 99%

Effects of ketamine on electroencephalographic and autonomic arousal and segmental reflex responses in the cat

Taylor

Vierck

2003

Veterinary Anaesthesia and Analgesia

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“…Induction of anaesthesia was implemented with ketamine (10 mg/kg, i.v. ); the trachea was intubated, and the cat was placed in the stretch reflex apparatus (Taylor et al . 1993).…”

Section: Methodsmentioning

confidence: 99%

Effects of dorsolateral spinal lesions on stretch reflex threshold and stiffness in awake cats

Taylor

Munson

Vierck

1999

Eur J of Neuroscience

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Measurements of threshold angle and incremental dynamic stiffness (IDS) were derived from triceps surae stretch reflexes, elicited by ramp and hold flexion at the ankle joint of four cats that were tested while awake. Stretch reflexes were assessed from trials that began from different ankle joint start positions or were matched using a post-hoc analysis for initial background force during testing sessions before and following unilateral lesions of the dorsolateral funiculus at levels ranging from T13 to L3. Unilateral lesions of the dorsolateral funiculus (DLF) produced significant ipsilateral decreases in stretch reflex threshold and increases in reflex gain, measured as incremental dynamic stiffness (IDS). ANCOVA testing indicated that the reduction in threshold, but not the increase in IDS, was dependent upon the level of background force. Reflex testing from different start angles demonstrated that DLF lesions diminished the correlation between threshold and IDS. Intravenous infusion of ketamine dose-dependently reduced IDS, compared with testing in the unanaesthetized state. Postoperative reflex testing during infusion of ketamine at 22.2 mg/kg per h, when electromyographic responses were reduced to 24% of control levels, abolished differences in IDS between the ipsilateral and contralateral hindlimbs. These and related observations suggest that the postoperative increase in IDS in awake animals was not due to an increase in passive stiffness.

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Development of an Animal Model for the Study of Spinal Spasticity

Cited by 2 publications

References 26 publications

Effects of ketamine on electroencephalographic and autonomic arousal and segmental reflex responses in the cat

Effects of ketamine on electroencephalographic and autonomic arousal and segmental reflex responses in the cat

Effects of dorsolateral spinal lesions on stretch reflex threshold and stiffness in awake cats

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