Reflectometry techniques on the Second Target Station at ISIS: Methods and science

Webster, John R. P.; Langridge, S.; Dalgliesh, R. M.; Charlton, Timothy

doi:10.1140/epjp/i2011-11112-y

Cited by 49 publications

(42 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structure of the bilayers was studied through neutron reflectivity at the OFFSPEC reflectometer at ISIS, the pulsed neutron and muon source at the Rutherford Appleton Laboratory in Oxfordshire, UK. 41,42 OFFSPEC is a vertical, flexible, low background, reflectometer and was used in its unpolarized mode.…”

Section: Elastic and Quasi-elastic Neutron Scatteringmentioning

confidence: 99%

Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

et al. 2015

View full text Add to dashboard Cite

We have studied nanoscale diffusion of membrane hydration water in fluid-phase lipid bilayers made of 1,2-dimyristoyl-3-phosphocholine (DMPC) using incoherent quasi-elastic neutron scattering. Dynamics were fit directly in the energy domain using the Fourier transform of a stretched exponential. By using large, 2-dimensional detectors, lateral motions of water molecules and motions perpendicular to the membranes could be studied simultaneously, resulting in 2-dimensional maps of relaxation time, τ, and stretching exponent, β. We present experimental evidence for anomalous (sub-diffusive) and anisotropic diffusion of membrane hydration water molecules over nanometer distances. By combining molecular dynamics and Brownian dynamics simulations, the potential microscopic origins for the anomaly and anisotropy of hydration water were investigated. Bulk water was found to show intrinsic sub-diffusive motion at time scales of several picoseconds, likely related to caging effects. In membrane hydration water, however, the anisotropy of confinement and local dynamical environments leads to an anisotropy of relaxation times and stretched exponents, indicative of anomalous dynamics.

show abstract

Section: Elastic and Quasi-elastic Neutron Scatteringmentioning

confidence: 99%

Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Neutron reflectivity (NR) measurements were carried out at the ISIS Spallation Neutron Source, Rutherford Appleton Laboratory, Didcot, UK, using the SURF [31] and INTER [32] reflectometers. The reflectivity R(Q z ) was measured using the time-of-flight technique as a function of momentum transfer normal to the interface Q z = (4π sin θ)/λ, where λ and θ are the wavelength and the grazing angle of incident neutrons, respectively.…”

Section: Neutron Reflectivitymentioning

confidence: 99%

Interactions of NIPAM nanogels with model lipid multi-bilayers: A neutron reflectivity study

Sun

Zielińska

Resmini

et al. 2019

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

In dermal drug delivery, the influence of the chemical structure of the carriers on their penetration mechanisms is not yet fully understood. This is a key requirement in order to design highly efficient delivery systems. In this study, neutron reflectivity is used to provide insights into the interactions between thermoresponsive N-isopropylacrylamide based nanogels, cross-linked with 10%, 20% and 30% N,N'-methylenebisacrylamide, and skin lipid multi-bilayers models. Ceramide lipid multi-bilayers and ceramide/cholesterol/behenic acid mixed lipid multi-bilayers were used for this work. The results indicated that in both multi-bilayers the lipids were depleted by the nanogels mainly through hydrophobic interactions. The ability of nanogels to associate with skin lipids to form water-dispersible complexes was found to be a function of the percentage cross-linker. An enhanced depletion of lipids was further observed in the presence of benzyl alcohol, a well-known skin penetration enhancer.

show abstract

“…The neutron reflection measurements were made on INTER at ISIS, Rutherford Appleton Laboratory [26,27]. The instrument uses a spallation target neutron source and determines the wavelength of the neutrons (lambda 1-15 Å) by time of flight to the detector.…”

Section: Neutron Reflectionmentioning

confidence: 99%

Adsorption of sodium hexanoate on α-alumina

Lee¹,

Welbourn²,

Clarke³

et al. 2013

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

a b s t r a c tNeutron reflection and adsorption isotherm measurements have been used to study the adsorption behaviour of hexanoic acid onto a-alumina surfaces. Importantly, the pH dependence of the behaviour has been characterised with a pronounced maximum in adsorption identified at a pH of approximately 5, close to the pK a of the acid. The adsorbed layer is identified as a bilayer, which is reasonable given the hydrophilic nature of both side of the layer, and has a thickness of 13 Å, suggesting significant extent of interdigitation. At pH 5, the layer has much lower extent of hydration relative to the higher pH of 7, consistent with the increased total adsorption at pH 5. A number of different mechanisms for the binding of the hexanoic acid to the surface are considered. The experimental data, combined with calculations using equilibrium/binding constants of the surface and ligands, indicates that a ligand exchange reaction may be the most significant mechanism.

show abstract

Reflectometry techniques on the Second Target Station at ISIS: Methods and science

Cited by 49 publications

References 10 publications

Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

Anomalous and anisotropic nanoscale diffusion of hydration water molecules in fluid lipid membranes

Interactions of NIPAM nanogels with model lipid multi-bilayers: A neutron reflectivity study

Adsorption of sodium hexanoate on α-alumina

Contact Info

Product

Resources

About