Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation

Kito, Shinji; Koga, Hirofumi; Kodama, Masaaki; Yamamoto, Noriaki; Kokuryo, Shinya; Habu, Manabu; Matsuo, Keitaro; Nishino, Takanobu; Kubota, Kohzoh; Muraoka, Kosuke; Oda, Masafumi; Wakasugi-Sato, Nao; Matsumoto-Takeda, Shinobu; Seta, Yuji; Tanaka, Tatsurou; Miyamoto, Ikuya; Yamashita, Yuichi; Kitamura, Chiaki; Nakashima, Keisuke; Takahashi, Tsuneo; Tominaga, Kazuhiro; Morimoto, Yasuhiro

doi:10.1016/j.oooo.2012.05.027

Cited by 26 publications

(29 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The areas of 18 F-FDG accumulation might induce a false-positive diagnosis of primary lesions in gingival cancers, and an appropriate differential diagnosis between periodontal or periapical inflammations and malignant tumours in the gingiva on PET images may not be possible. 11 Therefore, careful attention to clinical findings and clinical history is needed, and it is important to note findings such as dental inflammation, redness, swelling, oppressive pain, spontaneous pain and so on. At the same time, abnormal imaging findings on panoramic radiographs, CT and MR images should be examined in PET-positive and PET-suspected positive areas.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10] However, the ratio of 18 F-FDG accumulation in the oral cavity is relatively high because of tonsil-related tissues, sublingual glands, dental inflammation etc. 1,[11][12][13] In addition, it is known empirically that various areas in the oral cavity show substantial variations in the uptake that can present difficulties for identifying primary oral cancers.…”

Section: Introductionmentioning

confidence: 99%

“…A value of 2.5 was selected as the cut-off SUV max , because the extent of 18 F-FDG accumulation into malignant tumour was commonly greater than 2.5. 11,[14][15][16] In the respective areas, the precise SUV max of 18 F-FDG was measured on PET/CT images. As anatomical landmarks in the oral cavity showed accumulation of 18 F-FDG, the pharynx, pharyngeal tonsil, palatine tonsils, lingual tonsillar tissue and sublingual glands were cited previously 1 and excluded in the present study.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-d-glucose accumulations in the oral cavity of patients with oral cancers

Kito

Koga

Kodama

et al. 2013

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

Objectives: To elucidate the points that require attention when interpreting fluorine-18-labelled fluoro-2-deoxy-D-glucose ( 18 F-FDG)/positron emission tomography (PET) images by demonstration of 18 F-FDG accumulation in various areas of the oral cavity other than primary lesions in patients with oral cancers. Methods:18 F-FDG accumulations with a maximal standardized uptake value of over 2.5 in various areas of the oral cavity other than primary lesions were identified in 82 patients with oral cancers. Results:18 F-FDG/PET-positive areas, excluding primary tumours, included the front intrinsic muscles of the tongue (89.0%), upper and lower marginal parts of the orbicularis oris muscle (64.6%), sublingual glands, palatine tonsil, pharyngeal tonsil, and lingual tonsil. In addition, some areas in the jaws also showed accumulation. Conclusions: In patients with oral cancers, areas of 18 F-FDG accumulation in the oral cavity should be precisely identified and appropriately diagnosed, because accumulations can be seen in areas other than the primary tumour.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-d-glucose accumulations in the oral cavity of patients with oral cancers

Kito

Koga

Kodama

et al. 2013

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

show abstract

“…Another study on the use of PET/CT reported that 18F-FDG accumulations reflects extent of inflammation but not dental caries. 11 PET/CT for all malignant tumors except early gastric cancer is covered by National Health Insurance in M A N U S C R I P T…”

Section: Discussionmentioning

confidence: 99%

The potential of positron emission tomography/computerized tomography (PET/CT) scanning as a detector of high-risk patients with oral infection during preoperative staging

Yamashiro

Nakano

Sawaki

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

“…in ammation/infection, periodontitis, and apical periodontitis (27)(28). In the Kito et al (2012) study (28), periodontitis was scored by panoramic radiograph, which is not a reliable way to measure the severity and extension of this typical disease. Shimamoto et al (2008) (27) used clinical measurements of periodontitis, resulting in a more reliable severity score.…”

Section: Two Previous Studies Found a Correlation Between Visual [ 18mentioning

confidence: 99%

The Relationship between 18F-FDG Uptake in the Oral Cavity, Recent Dental Treatments, and Oral Inflammation or Infection: A Retrospective Study of Patients with Suspected Endocarditis

Slart¹,

Glaudemans

Erba

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Poor oral health has long been associated with the development of systemic disease. The risk of infective endocarditis (IE) after dental procedures is a typical example. However, the literature is conflicting about the causal relationship between oral bacterial pathogens and risk of IE. [18F]FDG PET/CT has proven to be a useful diagnostic tool in patients with suspected IE. This study focused on: 1) the correlation between increased glucose metabolism on [18F]FDG PET/CT scans, recent dental treatment, and inflammation and/or infection sites in the oral cavity reported by the dentist; and 2) a possible correlation between IE and oral health status based on (extra)cardiac findings on [18F]FDG PET/CT scans. Methods: This retrospective study included 52 patients (32 men, 20 women; median age, 58 years; IQR [44-66] years). A total of 19 patients were diagnosed with IE (group 1), 14 patients with possible IE (group 2), and 19 patients were not diagnosed with IE based on the modified Duke criteria (group 3). Patient characteristics and dental records were reviewed for relevant clinical data at the time the [18F]FDG PET/CT scan was performed. All [18F]FDG PET/CT scans were examined visually by pattern recognition using a three-point scale, and semi-quantified within the volume of interest (VOI) using SUVmax. The Fisher’s exact probability test and Pearson’s correlation were used to analyze the relationship between dental oral cavity findings and [18F]FDG PET/CT scans. A one-way ANOVA was conducted to compare the SUVmax measured in the oral cavity. To analyze the differences among visual [18F]FDG uptake scores in groups 1, 2, and 3, the Kruskal-Wallis H test was used. Results: No correlation was found between visual [18F]FDG uptake scores and SUVmax as a marker of [18F]FDG uptake and possible sites of oral inflammation and infection, or dental treatments based on the dental records of 52 patients. Between groups 1, 2, and 3, the visual [18F]FDG uptake scores (H(2) = 4.359, p = .113) and SUVmax (F(2, 69) = 0.27, p = .798) were not significantly different. A significant difference in SUVmax of the valve for the three groups (F(2, 309) = 28.06, p < .001) was observed.Conclusions: The results of this retrospective study suggest that no correlation exists between [18F]FDG PET/CT uptake in the oral cavity and dental treatments or inflammation/infection reported by the dentist. Furthermore, no correlation between IE and actual oral health status was demonstrated. This study revealed no causal relationship between oral pathogens and risk of IE. Additional research is needed to conclude whether [18F]FDG PET/CT imaging is a reliable diagnostic modality for oral inflammation and infection sites.

show abstract

Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation

Cited by 26 publications

References 17 publications

Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-d-glucose accumulations in the oral cavity of patients with oral cancers

Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-d-glucose accumulations in the oral cavity of patients with oral cancers

The potential of positron emission tomography/computerized tomography (PET/CT) scanning as a detector of high-risk patients with oral infection during preoperative staging

The Relationship between 18F-FDG Uptake in the Oral Cavity, Recent Dental Treatments, and Oral Inflammation or Infection: A Retrospective Study of Patients with Suspected Endocarditis

Contact Info

Product

Resources

About