The potential of positron emission tomography/computerized tomography (PET/CT) scanning as a detector of high-risk patients with oral infection during preoperative staging

Yamashiro, Keisuke; Nakano, Makoto; Sawaki, Koichi; Okazaki, Fumihiko; Hirata, Yukari; Takashiba, Shogo

doi:10.1016/j.oooo.2016.04.006

Cited by 11 publications

(6 citation statements)

References 11 publications

(9 reference statements)

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“…Regarding the use of FDG-PET/CT for the evaluation of periodontal disease, 18 F-FDG is actually an excellent tracer for the detection of inflammation. Some human studies have demonstrated that useful information about the inflammation of a cavity can be obtained in addition to the detection of primary tumors, metastatic disease, and lymph node metastasis [ 13 , 16 , 24 , 25 ]. The density of 18 F-FDG is proportional to the degree of inflammation from oral infections [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis?

et al. 2020

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Background: Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the treatment response to RA. This study aimed to examine the relationship between the extent of PD and the treatment response to biologics in RA patients using FDG-PET/CT. Methods: Sixty RA patients (male, n = 14; female, n = 46; average age, 58.3 years) treated with biologic agents were included in this study. FDG-PET/CT was performed at baseline and 6 months after the initiation of biological therapy. The maximum standardized uptake value (SUVmax) was used as a representative value for the assessment of the FDG uptake in periodontal tissue and joints including the bilateral shoulders, elbows, wrists, hip, knees, and ankle joints. The Disease Activity Score (DAS) 28-CRP and the following clinical parameters were assessed: C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF), and matrix metalloproteinase 3 (MMP-3). The relationship between the treatment response of RA and the baseline SUVmax of the periodontal tissue was evaluated. Results: The baseline periodontal SUVmax was related to patient age (r = 0.302, p = 0.009) and the ACPA level (r = 0.265, p = 0.025). The DAS28-CRP, CRP, ESR, MMP-3, and joint SUVmax values were significantly decreased after 6 months of biological therapy. However, the mean periodontal SUVmax, ACPA, and RF showed no significant changes after treatment. There was a significantly negative correlation between the baseline periodontal SUVmax and the treatment response of DAS28-CRP (r = − 0.369, p = 0.004). Conclusion: There was a negative correlation between the extent of PD at baseline and the treatment response of RA patients who received biological therapy. The evaluation of the periodontal condition is considered to be an essential part for the management of RA.

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Section: Discussionmentioning

confidence: 99%

Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis?

et al. 2020

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“…Yamashiro et al reported increased FDG uptake in acute periodontal disease, acute apical periodontitis, and pericoronitis of third molars [21]. The authors also detected an association between FDG uptake and radiological degree of inflammation.…”

Section: Comparison With Existing Literaturementioning

confidence: 89%

FDG-PET/CT for oral focus assessment in head and neck cancer patients

et al. 2022

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Objectives To compare oral and maxillo-mandibular inflammatory foci on standard oral radiographs (OPT, periapical radiograph) with available fluorine-18-labelled fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) data and to discuss whether additional metabolic information derived from FDG-PET/CT can support oral care specialists when performing oral focus examinations. Materials and methods Data from 23 patients with head and neck cancer who underwent FDG-PET/CT and panoramic and periapical radiography in close succession before first-line radiotherapy and/or chemotherapy were included in this exploratory retrospective study. Periapical lesions and marginal periodontal inflammation on FDG-PET/CT scans and standard oral radiographs were analysed and compared with regard to metabolic activity on FDG-PET/CT in comparison to recorded clinical symptoms and radiological scores. Additionally, inflammatory maxillo-mandibular pathologies were analysed using FDG-PET/CT. Results The maximum standardised uptake value (SUVmax) in FDG-avid marginal periodontal sites could not be conclusively associated with the radiologically recorded severity of marginal bone loss, but a potential positive correlation was identified. No association was found either between the metabolic activity of periapical lesions and their extent, as recorded on standard oral radiographs, or regarding clinical symptoms (percussion test). Most maxillo-mandibular pathologies did not show increased FDG uptake. Conclusions FDG-PET/CT provided additional metabolic information that can help clinicians identify lesions with increased inflammatory activity. The incorporation of available oral FDG-PET/CT findings into the primary oral focus assessment may allow for more accurate oral focus treatment. Clinical relevance FDG-PET/CT provides valuable metabolic information for oral care specialists. The detection of inflammatory oral processes using FDG-PET/CT facilitates treatment.

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“…In the human literature, there are various interesting applications for non-oncologic PET imaging of the head and neck. A few reports have assessed the value of 18 F-FDG PET for identification of periodontal disease or apical periodontitis (26–28). Although 18 F-FDG PET had not been performed for the primary purpose of periodontal assessment, these studies demonstrated that useful information regarding the oral cavity can be obtained when patients are imaged with PET for other indications.…”

Section: Non-oncologic Pet Imaging Of Head and Neckmentioning

confidence: 99%

Role of Positron Emission Tomography in Imaging of Non-neurologic Disorders of the Head, Neck, and Teeth in Veterinary Medicine

2019

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Positron Emission Tomography (PET) is an imaging technique that provides functional information, in addition to structural information obtained with computed tomography (CT). The most common application is cancer staging, using 18 F-Fluorodeoxyglucose ( 18 F-FDG), a radioactive analog of glucose. Although limited data are available in the veterinary literature, human studies have demonstrated benefit with the addition of PET both for assessment of the primary tumor and for detection of metastatic disease. 18 F-FDG PET appears to be more accurate at detecting the margin of oral neoplasia, in particular for tumors arising from highly vascularized tissue, such as the lingual and laryngeal areas. 18 F-FDG PET has a high sensitivity for the detection of lymph node metastasis, however the specificity is variable between studies. Tracers beyond 18 F-FDG can also be used for oncology imaging. 18 F-Fluoride ( 18 F-NaF) is an excellent osseous tracer, useful in assessing bone involvement of primary tumors or osseous metastasis. Other specific tracers can be used to assess cell proliferation or hypoxia for tumor characterization. 18 F-FDG is also an excellent tracer for detection of inflammation. Human studies have demonstrated its value for the assessment of periodontitis and dental implant infection. 18 F-NaF has been used to assess disorders of the temporomandibular joint in the human literature, demonstrating good correlation with arthralgia and therapeutic outcome. Both 18 F-NaF and 18 F-FDG had good concordance with localization of cervical pain in people. PET will likely have a growing role in veterinary medicine not only for oncologic imaging but also for assessment of inflammation and pain.

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The potential of positron emission tomography/computerized tomography (PET/CT) scanning as a detector of high-risk patients with oral infection during preoperative staging

Cited by 11 publications

References 11 publications

Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis?

Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis?

FDG-PET/CT for oral focus assessment in head and neck cancer patients

Role of Positron Emission Tomography in Imaging of Non-neurologic Disorders of the Head, Neck, and Teeth in Veterinary Medicine

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