Reflectance spectrophotometry, cerebral blood flow and congestion in young rabbit brain

Takashima, Sachio; Ando, Yukinori

doi:10.1016/s0387-7604(88)80040-8

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…In addition, NIRS was used to prevent hypoxia through monitoring newborn and premature infants [10,11]. Of note, NIRS had also been used to investigate the brains of animals [38][39][40].…”

Section: Nirs Until 1990mentioning

confidence: 99%

Vector-Based Approach for the Detection of Initial Dips Using Functional Near-Infrared Spectroscopy

Kato¹

2019

Neuroimaging - Structure, Function and Mind

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Functional near-infrared spectroscopy (fNIRS) is a non-invasive method for the detection of local brain activity using changes in the local levels of oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb). Simultaneous measurement of the levels of oxyHb and deoxyHb is an advantage of fNIRS over other modalities. This review provides a historical description of the physiological problems involved in the accurate identification of local brain activity using fNIRS. The need for improved spatial and temporal identification of local brain activity is described in terms of the physiological challenges of task selection and placement of probes. In addition, this review discusses challenges with data analysis based on a single index, advantages of the simultaneous analysis of multiple indicators, and recently established composite indicators. The vector-based approach provides quantitative imaging of the phase and intensity contrast for oxygen exchange responses in a time series and may detect initial dips related to neuronal activity in the skull. The vector plane model consists of orthogonal vectors of oxyHb and deoxyHb. Initial dips are hemodynamic reactions of oxyHb and deoxyHb induced by increased oxygen consumption in the early tasks of approximately 2-3 seconds. The new analytical concept of fNIRS, able to effectively detect initial dips, may extend further the clinical and social applications of fNIRS.

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“…In addition, NIRS was used to prevent hypoxia through monitoring newborn and premature infants [10,11]. Of note, NIRS had also been used to investigate the brains of animals [38][39][40].…”

Section: Nirs Until 1990mentioning

confidence: 99%

Vector-Based Approach for the Detection of Initial Dips Using Functional Near-Infrared Spectroscopy

Kato¹

2019

Neuroimaging - Structure, Function and Mind

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“…Carbon dioxide-induced cerebral vasodilation results in a proportional increase in CBV and CBF in experimental animals over a wide range of PaC02 (4)(5)(6)(7). In human adults the CBV-C 0 2 and CBF-C02 reactivities are 1:2 to 1:4 (8,9).…”

mentioning

confidence: 99%

Carbon Dioxide-Related Changes in Cerebral Blood Volume and Cerebral Blood Flow in Mechanically Ventilated Preterm Neonates: Comparison of Near Infrared Spectrophotometry and 133Xenon Clearance

et al. 1990

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“…In vivo spectroscopy, which uses near-infrared (NIR) wavelengths (4-7) instead of visible wavelengths (8,9), takes advantage of effective photon penetration to detect hemoglobin oxygenation deep in the tissue. In the two-wavelength method, the wavelengths of 760 and 800 nm, the peak of deoxyhemoglobin and the isobestic point in the NIR spectra of oxyhemoglobin and deoxyhemoglobin have been used as indexes of tissue oxygenation.…”

mentioning

confidence: 99%

Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy

et al. 1993

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To quantify the changes in oxygen saturation of hemoglobin in the liver in hypoxia and liver transplantation, we applied a novel method using near-infrared spectroscopy. Instead of the conventional two-wave-length method, we obtained near-infrared data from a wide spectral range of 700 nm to 1,000 nm with continuous-wave spectroscopy. To correct the flattened spectral shape caused by photon scattering in living tissue, we then applied an equation taking into account the relationship between absorber concentration and actual absorption in scattering materials as assessed with time-resolved spectroscopy. Hepatic hemoglobin oxygen saturation was calculated with multicomponent analysis. In room air, hepatic hemoglobin oxygen saturation of rabbit was calculated as 57.4% +/- 2.5% (mean +/- S.E.M., n = 7). Arterial, portal and hepatic venous hemoglobin oxygen saturation were simultaneously measured as 97.5% +/- 0.7%, 77.1% +/- 3.4% and 55.5% +/- 4.6%, respectively. The changes in hepatic hemoglobin oxygen saturation seen in graded hypoxia were also close to those in hepatic venous hemoglobin oxygen saturation, suggesting that the average oxygenation state of sinusoidal blood approximates that in the central vein. We tested the clinical applicability of this method in a case of liver transplantation. It was determined that the hepatic hemoglobin oxygen saturation of the graft liver was heterogeneously distributed and that the initially low level of hepatic hemoglobin oxygen saturation was increased by the ligation of portal-systemic shunts.

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Reflectance spectrophotometry, cerebral blood flow and congestion in young rabbit brain

Cited by 9 publications

References 5 publications

Vector-Based Approach for the Detection of Initial Dips Using Functional Near-Infrared Spectroscopy

Vector-Based Approach for the Detection of Initial Dips Using Functional Near-Infrared Spectroscopy

Carbon Dioxide-Related Changes in Cerebral Blood Volume and Cerebral Blood Flow in Mechanically Ventilated Preterm Neonates: Comparison of Near Infrared Spectrophotometry and 133Xenon Clearance

Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy

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