Mentougou District acts as a crucial component in the ecological buffer in western Beijing mountainous areas, Beijing, China. Using two Landsat MSS/TM images acquired on July 14, 1979 and July 23, 2005, the vegetation coverage of Mentougou District was calculated based on normalized difference vegetation index and spectral mixture analysis (NDVI-SMA) model. Its temporal and spatial changes were analyzed according to digital elevation model (DEM) image, social and economic data. The results showed that the vegetation coverage decreased from 76.4% in 1979 to 72.7% in 2005. Vegetation degradation was probably the result of human disturbance, such as outspreading of resident areas, and coal and stone mining activities, while vegetation restoration might be contributed by the combined effects of both natural processes and ecological construction effort. Vegetation changes were closely related to topographical characteristics. Plants at high altitude were more stable and less degraded than the plants at low altitude, while the plants on steep slope or northwest aspect were more vulnerable to degradation. During the period of 26 years, landscape appeared to become more fragmental, and ecological quality of the land seemed deteriorated sharply in that highly-covered vegetation area has been decreased by 24%.