Referred and secondary orofacial pain syndromes

Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities

“…Neuropathic pain significantly interferes with sleep and patients with TN had a higher risk for developing sleep disorders ( Wu, 2015 ). For instance, nearly 60% of patients with TN reported experiencing occasional awakenings due to pain ( Devor et al, 2008 ) and they were four times more likely to wake up during sleep than people without trigeminal neuropathy ( Benoliel et al, 2009 ). Results from experimental studies also showed that neuropathic pain causes sleep disturbance with an increase in wakefulness and a decrease in non-rapid eye movement sleep in mice with sciatic nerve injury ( Ito, 2013 , Koh et al, 2015 ).…”

Dental sleep-related conditions and the role of oral healthcare providers: A scoping review

“…3 [22,63] reported the use of the International Headache Society criteria by dentists to assess migraine and chronic daily headache (viz., chronic migraine, chronic tension-type headache, and other chronic daily headache), which were found to be associated with the presence of painrelated awakenings and sleep disturbance, respectively. One study reported dentist assessing the frequency of morning headache based on patients' self-report [64].…”

Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective

“…Disturbed sleep might exacerbate neuropathic pain; however, a causal bidirectional association between them has also been implied [147,148]. Neuropathic pain when associated with herpetic/post-traumatic trigeminal nerve dysfunction, or diabetes negatively impacts sleep quality resulting in characteristics of insomnia [147,[149][150][151].…”

“…Other factors such as social security and employment conditions negatively impact cognitive functions and the development of a sense of insecurity resulting in poor sleep [157]. Molecular studies have revealed that the dysregulated miRNAs in a patient with sleep-related epilepsy syndromes include miRNA-211, miRNA-155, miRNA-328, miR 194-5p, and miR 106b associated with CHRNA4, CHRNA2 CHRNB2 SCN1A, PAXNEB, GRIN2A, EFHC1, ClCN2, KCNQ3, KCNMB3, GABRA1, BRD2, KCNJ10, and CACNA1A [143,[151][152][153][154][155][156][157][158][159].…”