Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective

Abstract

Increasing incidences of insomnia in adults, as well as the aging population, have been reportedfor their negative impact on the quality of life. Insomnia episodes may be associated with neurocognitive, musculoskeletal, cardiovascular, gastrointestinal, renal, hepatic, and metabolic disorders. Epidemiological evidence also revealed the association of insomnia with oncologic and asthmatic complications, which has been indicated as bidirectional. Two therapeutic approaches including cognitive behavioral therapy (CBT) and drugsbased therapies are being practiced for a long time. However, the adverse events associated with drugs limit their wide and long-term application. Further, Traditional Chinese medicine, acupressure, and pulsed magnetic field therapy may also provide therapeutic relief. Notably, the recently introduced cryotherapy has been demonstrated as a potential candidate for insomnia which could reduce pain, by suppressing oxidative stress and inflammation. It seems that the synergistic therapeutic approach of cryotherapy and the above-mentioned approaches might offer promising prospects to further improve efficacy and safety. Considering these facts, this perspective presents a comprehensive summary of recent advances in pathological aetiologies of insomnia including COVID-19, and its therapeutic management with a greater emphasis on cryotherapy.

The relationship between gut microbiota and insomnia: a bi-directional two-sample Mendelian randomization research

“…In adults, 5.8% to 20% of the population suffers from insomnia, but the prevalence of insomnia in the elderly ranges from 30% to 48%. Insomnia disorder is among the top 10 reasons for general practitioners’ consultations ( Lo Yun et al., 2022 ). It is also a social and financial burden, raising questions about public health.…”