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doi:10.1002/9783527618156.refs

Cited by 5 publications

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Quantitative near infrared spectroscopic analysis of Q‐Switched Nd:YAG treatment of generalized argyria

et al. 2013

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Background and Objective Generalized argyria is a blue-gray hyperpigmentation of the skin resulting from ingestion or application of silver compounds, such as silver colloid. Case reports have noted improvement after Q-Switched Neodymium--Yttrium Aluminum Garnet laser (1064nm QS Nd:YAG) laser treatment to small surface areas. No reports have objectively monitored laser treatment of generalized argyria over large areas of skin, nor have long-term outcomes been evaluated. Study Design/Materials and Methods An incremental treatment plan was developed for a subject suffering from argyria. A quantitative near infrared spectroscopic measurement technique was employed to non-invasively analyze tissue-pigment characteristics pre- and post-laser treatment. Post-treatment measurements were collected at weeks 1, 2, 3, and 4, and again at 1 year. Results Immediate apparent removal of pigment was observed with 1 Q-switched 1064 nm Nd:YAG laser treatment (3-6 mm spot; 0.8-2 J/cm2) per area. Entire face, neck, upper chest and arms were treated over multiple sessions. Treatments were very painful and general anesthesia was utilized in order to treat large areas. Near-infrared spectroscopy was used to characterize and quantify the concentration of silver particles in the dermis based on the absorption features of the silver particles as well as the optical scattering effects they impart. We were able to estimate that there was, on average, 0.042 mg/mL concentration of silver prior to treatment and that these levels went below the minimum detectable limit of the instrument post-treatment. There was no recurrence of discoloration over the 1-year study period. Conclusion QS 1064 nm laser treatment of argyria is a viable method to restore normal skin pigmentation with no evidence of recurrence over study period. Quantitative spectroscopic measurements, 1) confirmed dyspigmentation was due to silver, 2) validated our clinical assessment of no recurrence up to one year post-treatment and 3) indicated no collateral tissue damage with treatments.

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Quantitative near infrared spectroscopic analysis of Q‐Switched Nd:YAG treatment of generalized argyria

et al. 2013

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One‐Pot Preparation of Organic–Inorganic Composite Microspheres Comprising Silica Nanoparticles and End‐Functionalized Polymers

Satoh

Yabu

2015

Macro Materials & Eng

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media hold particular promise for the creation of a unique class of functional materials with innovative applications such as highly sensitive sensors based on the plasmonic coupling of noble metal nanoparticles, and tough coloring materials based on photonic stop bands. [2][3][4] However, technologies for assembling inorganic nanoparticles into such favorable arrangements are required in order to realize these applications and functions.Several approaches based on colloidal chemistry have been attempted for assembling inorganic nanoparticles by using various interactions between the inorganic nanoparticles. For example, many types of colloidosomes have been created by tuning the hydrophobic and hydrophilic balance of inorganic nanoparticles through functionalization of the nanoparticle surfaces. [ 5 ] Hollow spherical assemblies of densely packed silica and other inorganic nanoparticles have been prepared using this approach, [ 6,7 ] as have "black golds," which have a unique plasmonic absorption and electromagnetic resonances. [ 8,9 ] However, colloidosomes easily disassemble when thermally Colloidal assemblies of inorganic nanoparticles dispersed in liquid media hold particular promise for the creation of a unique class of functional materials with innovative applications. In the present report, "compound-eye"-like core-shell and Janus-type silica and aminoterminated 1,2-polybutadiene (PB-NH 2 ) and polystyrene (PS) composite microspheres are successfully prepared by simply mixing an aqueous dispersion of silica particles into a tetrahydrofran (THF) solution of PB-NH 2 , and PB-NH 2 and PS blends, followed by evaporation of the THF. This co-precipitation process provides a new approach for producing organicinorganic composite particles without the need for surface modifi cation of the inorganic nanoparticles.

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