Reference values for left and right ventricular trabeculation and non-compacted myocardium

André, Florian; Burger, Astrid; Loßnitzer, Dirk; Buss, Sebastian J.; Abdel-Aty, Hassan; Gianntisis, Evangelos; Steen, Henning; Katus, Hugo A.

doi:10.1016/j.ijcard.2015.03.065

Cited by 33 publications

(35 citation statements)

References 19 publications

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“…It is characterized by a two-layered structure consisting of prominent trabeculations and inter-trabecular recesses [2–4]. The mechanistic basis for this cardiomyopathy remains controversial but it is thought to be secondary to an early fetal arrest of myocardial development with lack of compaction of the myocardial meshwork [2,3,5–7]. Based on the morphologic appearance of the myocardium, diagnostic criteria have been generated from different imaging modalities [8–12].…”

Section: Introductionmentioning

confidence: 99%

Noncompaction cardiomyopathy and heterotaxy syndrome

Martinez

Ware

Schamberger

et al. 2017

Progress in Pediatric Cardiology

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Left ventricular noncompaction cardiomyopathy (LVNC) is characterized by compact and trabecular layers of the left ventricular myocardium. This cardiomyopathy may occur with congenital heart disease (CHD). Single cases document co-occurrence of LVNC and heterotaxy, but no data exist regarding the prevalence of this association. This study sought to determine whether a non-random association of LVNC and heterotaxy exists by evaluating the prevalence of LVNC in patients with heterotaxy. In a retrospective review of the Indiana Network for Patient Care, we identified 172 patients with heterotaxy (69 male, 103 female). Echocardiography and cardiac magnetic resonance imaging results were independently reviewed by two cardiologists to ensure reproducibility of LVNC. A total of 13/172 (7.5%) patients met imaging criteria for LVNC. The CHD identified in this subgroup included atrioventricular septal defects [11], dextrocardia [10], systemic and pulmonary venous return abnormalities [7], and transposition of the great arteries [5]. From this subgroup, 61% (n = 8) of the patients developed arrhythmias; and 61% (n = 8) required medical management for chronic heart failure. This study indicates that LVNC has increased prevalence among patients with heterotaxy when compared to the general population (0.014–1.3%) suggesting possible common genetic mechanisms. Interestingly, mice with a loss of function of Scrib or Vangl2 genes showed abnormal compaction of the ventricles, anomalies in cardiac looping, and septation defects in previous studies. Recognition of the association between LVNC and heterotaxy is important for various reasons. First, the increased risk of arrhythmias demonstrated in our population. Secondly, theoretical risk of thromboembolic events remains in any LVNC population. Finally, many patients with heterotaxy undergo cardiac surgery (corrective and palliative) and when this is associated with LVNC, patients should be presumed to incur a higher peri-operative morbidity based on previous studies. Further research will continue to determine long-term and to corroborate genetic pathways.

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Section: Introductionmentioning

confidence: 99%

Noncompaction cardiomyopathy and heterotaxy syndrome

Martinez

Ware

Schamberger

et al. 2017

Progress in Pediatric Cardiology

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“…It is difficult to compare literature data because of the diverse evaluation of TPM volumes. The majority of prior studies presented data that was either papillary muscle or trabecular mass measurement in isolation [5][6][7][8]; few studies 1 3 are available which reported the sum of papillary and trabecular mass [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Although structural and functional evaluation of RV is challenging, CMR is an accurate method to evaluate thin free wall and trabeculation of right ventricle [1]. The right ventricular trabeculation are pronounced, but limited data is available regarding quantitative measurement of these structures in a normal population [9,14,15] or in pathological conditions [6,16]. Large population based studies provide normal RV values excluding small intracavitary structures from RV mass [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Left and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree

Csécs

Czimbalmos

Suhai

et al. 2018

Int J Cardiovasc Imaging

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While cardiac magnetic resonance (CMR) is the reference method to evaluate left and right ventricular functions, volumes and masses, there is no widely accepted method for the quantitative analysis of trabeculae and papillary muscles (TPM). The aim of this study was to investigate the effect of TPM quantification on left and right ventricular CMR values in a normal cohort and to investigate interobserver variability of threshold-based (TB) analysis by three independent observers with variant experience in CMR. At our clinic, 60 healthy volunteers (30 males, mean age 25.6 ± 4.7 years) underwent CMR scan performed on a 1.5T Philips Achieva MR machine. On short-axis cine images, endo-and epicardial contours were detected by three independent observers with variable experience in CMR (low-ca. 120, mid-> 800, high-experienced > 5000 original CMR cases). Using Conv and TB methods (Medis 7.6 QMass software Leiden, The Netherland), we measured LV and RV ejection fractions, end-diastolic, end-systolic, stroke volumes and masses. We used TB method for quantifying TPM in ventricles using epicardial contour layers. Interobserver variability was evaluated, and the observer's experience as an impact on variability of each investigated parameters was assessed. Comparing Conv and TB quantification methods' significant difference were detected for all LV and RV parameters in case of all observers (H, M and L p < 0.0001). The global intraclass correlation coefficient (G-ICC) representing interobserver agreement for all investigated parameters was lower with Conv method (G-ICC Conv vs. G-ICC TB 0.86 vs. 0.92 p < 0.0001). The ICC of LV parameters was higher using TB quantification (LV-ICC Conv vs. LV-ICC TB 0.92 vs. 0.96 p < 0.0001), and for the evaluation of RV values, the TB method also had significantly higher interobserver agreement (RV-ICC Conv vs. RV-ICC TB 0.80 vs. 0.89 p < 0.0001). The TB algorithm could be a consistent method to assess LV and RV CMR values, and to measure trabeculae and papillary muscles quantitatively in various level of experience in CMR.

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“…Следует дифференцировать физиологическую и патологическую гипертрабекулярность левого же-лудочка сердца [79]. F. Andre с соавт.…”

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“…F. Andre с соавт. [79] обследо-вал сердце у 117 волонтеров (58 мужчин) различ-ного возраста. Объем трабекул был значительно больше у мужчин, чем у женщин, и уменьшался с возрастом (r = 0,46; p < 0,001).…”

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Noncompaction Cardiomyopathy

Iljinsky

Mozheyko

Шевченко

2017

RJTAO

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1 ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация 2 Кафедра трансплантологии и искусственных органов ГБОУ ВПО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России, Москва, Российская Федерация В статье представлен обзор литературы по различным аспектам некомпактной кардиомиопатии. Не-компактная кардиомиопатия -относительно редкое врожденное заболевание сердца, характеризующе-еся чрезмерным развитием трабекулярной сети и глубокими межтрабекулярными впадинами миокарда желудочков. Наиболее часто встречается неуплотненный миокард левого желудочка (НМЛЖ). НМЛЖ может быть изолированным или сосуществовать с другими кардиальными и системными аномалиями. Неуплотнение диагностируют, используя эхокардиографию или магнитно-резонансную томографию. Клинические проявления варьируют в широких пределах -от бессимптомных пациентов до пациентов с желудочковыми аритмиями, застойной сердечной недостаточностью и тромбоэмболиями. Некомпакт-ный миокард является нерешенной клинической задачей в силу недостаточной точности неинвазивной диагностики и стратификации пациентов, определения прогноза и в ряде случаев -тактики их лечения. In this article, the review of the literature on various aspects of the noncompaction cardiomyopathy is presented. Non-compaction cardiomyopathy is a relatively rare congenital heart disease characterized by an excessive prominence of trabecular meshwork, and deep recesses of the ventricular myocardium. The most frequent is left ventricular noncompaction (LVNC). LVNC can occur in isolation or coexist with other cardiac and systemic anomalies. Noncompaction can be detected with an echocardiography or cardiac magnetic resonance imaging. The clinical presentation varies ranging from asymptomatic patients to patients who develop ventricular arrhythmias, heart failure, thromboembolism.

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Reference values for left and right ventricular trabeculation and non-compacted myocardium

Cited by 33 publications

References 19 publications

Noncompaction cardiomyopathy and heterotaxy syndrome

Noncompaction cardiomyopathy and heterotaxy syndrome

Left and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree

Noncompaction Cardiomyopathy

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