Reference Ranges and Determinants of Testosterone, Dihydrotestosterone, and Estradiol Levels Measured using Liquid Chromatography-Tandem Mass Spectrometry in a Population-Based Cohort of Older Men

Abstract

The 2.5th percentile in a reference group of healthy older men provides age-appropriate thresholds for defining low T, DHT, and E2. Additional studies are needed to test their potential applicability and clinical utility in older men.

Relationships between Anti-mullerian Hormone, Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Men on Testosterone Therapy

“…Testosterone ranges vary with age. Baseline testosterone was within age specific reference intervals in all men when using published data on men aged 21-35 years (range 10.4-30.1 nmol/L), older men aged 70-89 years (range 6.4-25.7 nmol/L) and specific age-related intervals recently reported by Kelsey et al [21][22][23]. The AMH reference intervals for men in our laboratory are 20-120 pmol/L for 19-40 year olds and for >40 years 15-72 pmol/L.…”

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

“…Estradiol levels seem to decrease with aging in men and women (Carcaillon et al, 2012b;Leifke et al, 2000;Yeap et al, 2012a). However, although a significant negative correlation of estradiol and estrone levels with frailty score in men aged ≥70 years has been reported (Travison et al, 2011), no significant association of circulating estradiol with frailty has been observed in other studies performed in older men Eichholzer et al, 2012;Yeap et al, 2012a) and no association of estradiol with physical performance or strength was established in female and male obese older adults (Aguirre et al, 2014). Furthermore, higher estradiol levels have been associated with frailty in postmenopausal women, a relationship synergized by the concomitant presence of systemic inflammation (Carcaillon et al, 2012b).…”

Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community‐dwelling men

“…T is converted by 5-alpha reductase to DHT, which is a 2-10 times more potent androgen as a ligand for the androgen receptor [8]. Associations of DHT with prevalent cardiovascular disease (CVD), and with the incidence of stroke and all-cause mortality are concordant with associations of T [7,9,10]. However, higher DHT has been associated with lower risk of mortality due to ischaemic heart disease [10].…”